A prosthetic heart valve for replacing a native valve includes a collapsible and expandable stent extending between a proximal end and a distal end, the stent including an annulus section adjacent the proximal end and an aortic section adjacent the distal end. The annulus section has cells arranged in at least one annulus row, each annulus row having a same first number of cells, the first number defining a first cell density. The aortic section has cells arranged in at least one aortic row, each aortic row having a same second number of cells, the second number defining a second cell density, the first cell density and the second cell density being different. A valve assembly is disposed within the stent.

A device for placement in the aortic arch of a patient is provided. The device includes a distal portion for being engageably received in an aortic arch of a patient beyond the left subclavian artery and a stent portion fluidly engaged with the distal portion, the stent portion being permeable and configured to span a portion of the aortic arches to which the brachiocephalic trunk, left common carotid artery, and left subclavian artery attach to the aortic arch. A diameter of the stent portion may be modified by translation of the proximal portion to thereby alter a length of the stent portion thus causing modification of the diameter of the stent portion to fit anatomical features of differing dimensions.

Described herein are flexible implantable occluding devices that can, for example, navigate the tortuous vessels of the neurovasculature. The occluding devices can also conform to the shape of the tortuous vessels of the vasculature. In some embodiments, the occluding devices can direct blood flow within a vessel away from an aneurysm or limit blood flow to the aneurysm. Some embodiments describe methods and apparatus for adjusting, along a length of the device, the porosity of the occluding device. In some embodiments, the occluding devices allows adequate blood flow to be provided to adjacent structures such that those structures, whether they are branch vessels or oxygen-demanding tissues, are not deprived of the necessary blood flow.

Materials for soft tissue repair, and in particular, material for hernia repair. These materials may be configured as an implant, such as a graft, that may be implanted into a patient in need thereof, such as a patient having a hernia or undergoing a hernia repair surgical procedure. These grafts may include a first layer comprising a substrate (e.g., mesh) and a second layer comprising a sheet of anti-adhesive material. The layers may be attached with a plurality of relatively small attachment sites that are separated by regions in which the two layers are not attached, to provide a highly compliant graft.

Described are surgical implants that include releasable reinforcement, and related methods, particular example implants and methods being useful for treating pelvic tissue, cardiac tissue, and hernia, wherein the releasable reinforcement can be released (removed or disabled) during a surgical procedure to affect a mechanical property of the implant or a portion of the implant.

Described herein are flexible implantable occluding devices that can, for example, navigate the tortuous vessels of the neurovasculature. The occluding devices can also conform to the shape of the tortuous vessels of the vasculature. In some embodiments, the occluding devices can direct blood flow within a vessel away from an aneurysm or limit blood flow to the aneurysm. Some embodiments describe methods and apparatus for adjusting, along a length of the device, the porosity of the occluding device. In some embodiments, the occluding devices allows adequate blood flow to be provided to adjacent structures such that those structures, whether they are branch vessels or oxygen-demanding tissues, are not deprived of the necessary blood flow.

A radially expandable, tubular stent, includes a first section having a first crush resistance force and a second section have a second crush resistance force, wherein the first crush resistance force is less than the second crush resistance force. The first section is connected to the second section to form a tube, connection of the first and second sections extending in an axial direction of the tube.

A prosthetic implant material for use in a prosthetic implant, comprising a gel and optionally a gas.

A tubular, folding flow diverter is provided. The flow diverter includes a plurality of sections, including a first section, a second section, and a third section. The flow diverter is shapeable to an elongated cylindrical shape and is movable to an implanted configuration. In the implanted configuration, the second section and at least a portion of the first and third sections overlap to form a three-layer shape. This three-layer shape can be positioned proximate an aneurysm neck when implanted in a patient. The overall porosity of the implant can be higher than legacy implants, because the overlapping portion of the three sections can decrease the porosity proximate the aneurysm neck.

Described are implants, intermediate articles of manufacture (web constructions) useful for preparing implants, methods of forming the implants and intermediate articles, and related methods for treating pelvic conditions by use of the implants. The present invention relates generally to surgical implants (i.e., “implants”), intermediate articles of manufacture (web constructions) useful for preparing surgical implants, methods of forming the implants and intermediate articles, and related methods for treating pelvic conditions by use of the implants.