The present disclosure relates to stent graft devices for endovascular repair of aneurysms. A stent graft device according to the present disclosure comprises: a membrane defining a lumen between a proximal end and a distal end of the membrane, the lumen for fluid communication distally therethrough; a plurality of fenestrations disposed on the membrane and fluidly communicable with the lumen; and a plurality of protrusions carried by the membrane, each protrusion extending inwardly into or outwardly from the lumen. Fluid communicated from the plurality of fenestrations is deflectable or deflected by the plurality of protrusions.

Expandable elements having drug-delivery features and associated systems and methods are disclosed herein. In one embodiment, a drug-eluting stent includes a radially expandable cylindrical frame having a plurality of struts. The frame is transformable between a low-profile delivery state and an expanded deployed state. A plurality of drug-delivery features are carried by one of the struts and configured to deliver a drug to a treatment site within the patient or piercing through the tissue wall to break the constricting of the vessel wall inwardly. When the frame is in the expanded state within a body lumen of the patient, the drug-delivery features extend radially outwardly away from the strut and are configured to engage and, in some arrangements, pass through a wall of the body lumen.

An aortic stent-graft may include a tubular graft extending from a proximal end to a distal end, the graft comprising a proximal sealing portion and an intermediate portion, wherein a proximal end of the intermediate portion abuts the distal end of the proximal sealing portion. At least one sealing stent may be attached to the proximal sealing portion. A first fenestration window is disposed in the intermediate portion. The first fenestration window has a length determined by the equation L=1.23*D−24 millimeters, where L is the length of the first fenestration window. D is between about 24 millimeters and 45 millimeters.

A primary stent-graft is deployed into a primary vessel to exclude an aneurysm. To maintain perfusion to a branch vessel covered by the primary stent-graft, a gutter filling stent-graft is deployed in parallel to the primary stent-graft. The gutter filling stent-graft includes a balloon that is pressurized and inflated by the patient's own blood thereby sealing any gutters formed around the gutter filling stent-graft. By sealing the gutters, the chance of type I endoleaks, migrations, and overall failure to exclude the aneurysm is minimized.

Medical devices and methods for making and using a medical device are disclosed. An example medical device may include a stent that comprises a first covered region formed of one or more interwoven filaments and a covering. The stent may also comprise a second uncovered region adjacent the first covered region. The second uncovered region may include a knitted filament. A first end of the knitted filament may be attached to the first covered region. The knitted filament is configured to be unraveled to remove both the first covered region and the second uncovered region of the stent while the first end of the knitted stent remains attached to the first covered region.

An intraluminal filtration device for embolic protection includes a device body and each of a coarse filter and a fine filter, for filtering larger-size and smaller-size particles, respectively. The device body includes a body wall extending circumferentially around the longitudinal axis, and being formed at least in part of an organic gel.

Implantable medical devices and prosthesis for rapid regeneration and replacement of tissues, and methods of making and using the devices, are described. The medical devices include a complex three-dimensional braided scaffold with a polymer composition and structure tailored to desired degradation profiles and mechanical properties. The composite three-dimensional braided scaffolds are braided from yarn bundles of biodegradable and bioresorbable polymeric fibers and/or filaments. Monofilament fibers and/or multifilament fibers can be twisted/plied in different combinations to form multifilament yarns, composite multifilament yarns, or composite yarns. The medical devices are useful as both structural prosthetics taking on the function of the tissue as it regenerates and as in vivo scaffolds for cell attachment and ingrowth.

An implantable device includes an outer tubular member defining a longitudinal axis and a lumen. The outer tubular member includes: an outer wall portion having a plurality of first strands defining a plurality of first openings therebetween, the outer wall portion having a first porosity; and an inner baffle portion disposed within the lumen, the inner baffle portion including a plurality of second strands defining a plurality of second openings therebetween, the inner baffle portion having a second porosity that is lower than the first porosity of the outer wall portion.

An intraluminal device and a method of removing a clot from a body lumen with an intraluminal device may be provided. The intraluminal device may include a hollow elongated shaft and a radially-expandable mesh segment situated distal to the elongated shaft. The elongated shaft may be secured relative to a first portion of the mesh segment. The intraluminal device may additionally include a core wire affixed to a second portion of the mesh segment and extending through the elongated shaft. The elongated shaft may be configured to radially expand the mesh segment by axially moving the first portion of the mesh segment relative to the second portion of the mesh segment. In addition, the core wire may be configured to radially expand the mesh segment by axially moving the second portion of the mesh segment relative to the first portion of the mesh segment.

A reconstruction support includes an upper half, a lower half joined to the upper half, a plurality of alignment perforations disposed on at least one of the upper half and the lower half, and a plurality of fenestrations disposed on at least one of the upper half and the lower half, the plurality of fenestrations configured to facilitate selective expansion of at least one of the upper half or the lower half, where the reconstruction support is inserted above muscle to facilitate breast reconstruction.