A coated medical device (10) including a structure (12) adapted for introduction into a passage or vessel of a patient. The structure is formed of preferably a non-porous base material (14) having a bioactive material layer (18) disposed thereon. The medical device is preferably an implantable stent or balloon (26) of which the bioactive material layer is deposited thereon. The stent can be positioned around the balloon and another layer of the bioactive material posited over the entire structure and extending beyond the ends of the positioned stent. The ends of the balloon extend beyond the ends of the stent and include the bioactive material thereon for delivering the bioactive material to the cells of a vessel wall coming in contact therewith. The balloon further includes a layer of hydrophilic material (58) positioned between the base and bioactive material layers of the balloon.

The present invention relates to a stent graft, comprising: a base stent having a first and a second longitudinal end, a lumen extending longitudinally through the base stent, a covering material provided so as to line the base stent, the base stent having a roughened surface that is at least partially penetrated by the covering material so as to form a positive fit.

Medical implants comprising biocompatible materials and having surface features that may assist in biocompatibility upon implantation in the body are described. Methods for manufacturing such implants are also described. The manufacturing process may include applying a biocompatible material to a texturized surface of a mold. The implants may include various features to assist their positioning, fixation, and/or identification during and/or after implantation.

A method of augmenting or reconstructing a breast of a patient includes providing an implantable member and implanting the implantable member. The implantable member includes an exterior surface defined by an anterior face and a posterior face, wherein one of the anterior face and the posterior face includes at least one fixation region defined by a texture, roughness or sheen different from a respective texture, roughness or sheen of a balance of said one of the anterior face and posterior face. The implantable member is implanted into a breast of a patient such that the fixation region of the implantable member generally aligns with the pectoralis major muscle group or the pectoralis minor muscle group.

A unitary intervertebral device, having no moving components is provided for non-fusion articulation and fusion applications. The interbody articulating device allows for limited flexion and rotation between the implant and an adjacent vertebrae, helping to preserve or restore near-normal motion between adjacent vertebrae. Rotational motion is achieved through one or more protrusions incorporated into the spinal interbody device. In one articulating form, a first protrusion extends perpendicularly from one bearing surface of the interbody device to form a rotational protrusion, while at least a second protrusion extends from the opposite bearing surface of the interbody device to form a non-rotational protrusion. In another form, a single protrusion extends axially from one bearing surface of the interbody device to form a spike or anchoring, rotating protrusion, while the opposite bearing surface may be slightly rounded and/or comprising a bone-ingrowth promoting surface. Similarly configured fusion salvage devices are also described.

A coated medical device (10) including a structure (12) adapted for introduction into a passage or vessel of a patient. The structure is formed of preferably a non-porous base material (14) having a bioactive material layer (18) disposed thereon. The medical device is preferably an implantable stent or balloon (26) of which the bioactive material layer is deposited thereon. The stent can be positioned around the balloon and another layer of the bioactive material posited over the entire structure and extending beyond the ends of the positioned stent. The ends of the balloon extend beyond the ends of the stent and include the bioactive material thereon for delivering the bioactive material to the cells of a vessel wall coming in contact therewith. The balloon further includes a layer of hydrophilic material (58) positioned between the base and bioactive material layers of the balloon.

Stents as described herein can comprise a tubular body in which a midbody extends to a first end and also extends to an opposing second end, where the midbody includes a thread arranged helically along at least a portion of its length. The thread can exhibit various shapes and dimensions selected to enhance particular aspects of performance when the stent placed in an anatomical structure of a patient.

An endoprosthesis device comprising a tubular structure having an outer surface and an inner surface such that the inner surface locates a lumen, and wherein the outer surface includes a microstructure pattern having hierarchical microstructures generating an adhesive effect to a target surface. The inner surface comprises a microstructure pattern that is superhydrophobic or oleophobic that is capable of being anti-fouling wherein the microstructure pattern of the inner surface comprises microridges. Additionally, the outer surface may include pores that fluidly connect the outer surface to the inner surface for transporting fluid from the target surface interface into the endoprosthesis lumen.

An implant for implantation into bone tissue includes an elongated body having an outer surface. The outer surface hast least one thread. The thread makes a number of turns around the body of the implant and includes a root, a flank and a crest. The root and a segment of the flank have a roughened portion compared to the crest. A method of forming an implant having a threaded outer surface including a root, a flank, and a crest includes treating the threaded outer surface at only the root and a portion of the flank while the crest remains untreated.

An improvement in drug-eluting stents, and method of their making, are disclosed. The surface of a metal stent is roughened to have a surface roughness of at least about 20 in (0.5 m) and a surface roughness range of between about 300-700 in (7.5-17.5 m). The roughened stent surface is covered with a polymer-free coating of a limus drug, to a coating thickness greater than the range of surface roughness of the roughened stent surface.