An intraocular lens, wherein an outer periphery of an optic portion has a peripheral surface, and a radially inner portion of a peripheral portion of the IOL has an inner surface, wherein the peripheral surface is directly adjacent to the inner surface, and wherein the peripheral surface does not directly extend (coupled to or integrally formed therewith) from the inner surface, and wherein the peripheral surface and the inner surface are configured so that the peripheral portion is stabilized in at least one of, and optionally both of, the proximal and distal directions relative to the optic portion.

A stent (scaffold) or other luminal prosthesis comprising circumferential structural elements which provide high strength after deployment and allows for scaffold to uncage, and/or allow for scaffold or luminal expansion thereafter. The circumferential scaffold is typically formed from non-degradable material and will be modified to expand and/or uncage after deployment.

A compressible and expandable stent assembly for implantation in a body lumen such as a mitral valve, the stent assembly including at least one stent barrel that is shaped and sized so that it allows for normal operation of adjacent heart structures. One or more stent barrels can be included in the stent assembly, where one or more of the stent barrels can include a cylinder with a tapered edge.

A penile sleeve device (PSD) that is an implantable subcutaneous penile shaft silicone rubber apparatus which has several functions such as to elongate, thicken, harden, straighten and custom shape a penis. The PSD has an elongated main component of stretchable elastic silicone elastomer into which an inner component of a much higher durometer silicone rubber material is positioned to provide the PSD with some rigidity. The main component is the only portion in contact with the penile shaft since the inner component resides within a pocket of the main component that is formed by two layers therein. The outside surface of these layers may include folds to assist in enhancing penile girth and lengthening. Other variations include collapsible, spoke, telescoping and fused PSD versions. Another version includes an elongated member having a C-shaped distal portion, a transitional portion and a shorter arcuate proximal portion and a pair of longitudinal edges with transversely-oriented V-cuts therein.

Assembly methods for installing a valvular structure to an expandable annular frame of a prosthetic heart valve are described. The valvular structure has a multiple leaflets, each with a pair of tabs. Each tab of the leaflet has upper and lower portions. Commissures formed by paired tabs of adjacent leaflets are coupled to corresponding commissure windows to support the valvular structure within the frame. Each commissure window has upper and lower openings separated from each other by a crossbar and may have an H-shape. The upper and lower tab portions extend through the upper and lower openings, respectively, of the corresponding commissure window. One or more wedge members coupled to the tab portions can prevent the leaflet tab from passing back through the commissure window, thereby retaining the valvular structure to the annular frame.

A heart valve replacement device comprises a stent having a first end, a second end, an outer surface, and an inner surface, the inner surface defining a lumen; and a valve disposed within the lumen of the stent, the valve formed from a single sheet of tissue, the valve having an outer surface, an inner surface, and a thickness between the outer surface and the inner surface, the valve comprising at least three leaflets, wherein, the valve is attached to the stent with minimal sutures. The leaflets are formed with a curvilinear surface.

A heart valve prosthesis, including a valved stent and valve leaflets, where the valve leaflets are accommodated in the valved stent, at least two valve leaflets are provided and centrosymmetrically distributed along the circumferential direction of an inner surface of the valve leaflet stent, one ends of each of two adjacent valve leaflets are combined together on the valve leaflet stent to form a valve corner, the valved stent is provided with a positioning member, and the projections of a perpendicular line of one of the valve corners to the axis of the valved stent and a perpendicular line of the positioning member to the axis of the valved stent are coincident on a plane perpendicular to the axis of the valved stent. The heart valve prosthesis can considerably reduce regurgitation at the center.

A prosthetic valve including a leaflet frame configured to be transitioned from a collapsed state having a first diameter to an expanded state having a second diameter that is larger than the first diameter. The leaflet frame has an inlet and outlet end and defining a longitudinal axis. The leaflet frame includes a plurality of frame members that form a framework defining plurality of cells each having an interior cell space, the plurality of cells including an attachment cell. The plurality of frame members includes a plurality of sub-cell attachment members extending into the interior cell space of the attachment cell, the sub-cell attachment members each being configured to define a plurality of attachment locations along a sub-cell attachment line defined within a plane that intersects with the longitudinal axis such that the sub-cell attachment line extends through the interior cell space of the at least one attachment cell.

Methods, compositions, and systems are provided for characterization of modified nucleic acids. In certain preferred embodiments, single molecule sequencing methods are provided for identification of modified nucleotides within nucleic acid sequences. Modifications detectable by the methods provided herein include chemically modified bases, enzymatically modified bases, abasic sites, non-natural bases, secondary structures, and agents bound to a template nucleic acid.

A transcatheter valve prosthesis includes a balloon expandable stent and a prosthetic valve. An inflow portion of the stent includes a plurality of crowns and a plurality of struts with each crown being formed between a pair of opposing struts. Endmost inflow side openings and endmost inflow crowns are formed at the inflow end of the stent and the inflow end of the stent has a total of twelve endmost inflow crowns. An outflow portion of the stent includes a plurality of crowns and a plurality of struts with each crown being formed between a pair of opposing struts. Endmost outflow crowns are formed at the outflow end of the stent and the outflow end of the stent has a total of six endmost outflow crowns. The prosthetic valve is disposed within and secured to the stent.