A prosthetic valve includes a frame and a flow control component. The frame has an aperture extending through the frame about a central axis. The flow control component is mounted within the aperture and is configured to permit blood flow in a first direction approximately parallel to the vertical axis from an inflow end to an outflow end of the flow control component and to block blood flow in a second direction, opposite the first direction. The frame has an expanded configuration with a first height along the central axis, a first lateral width along a lateral axis perpendicular to the central axis, and a first longitudinal length along a longitudinal axis perpendicular to the central axis and the lateral axis. The frame has a compressed configuration with a second height less than the first height and a second lateral width less than the first lateral width.

A compressible and expandable stent assembly for implantation in a body lumen such as a mitral valve, the stent assembly including at least one stent barrel that is shaped and sized so that it allows for normal operation of adjacent heart structures. One or more stent barrels can be included in the stent assembly, where one or more of the stent barrels can include a cylinder with a tapered edge.

A prosthetic assembly configured for endovascular placement within an aortic arch and method of use thereof. The prosthetic assembly includes a proximal aortic stent-graft prosthesis configured to be positioned within a proximal portion of the aortic arch adjacent to the brachiocephalic artery, a distal aortic stent-graft prosthesis configured to be positioned within a distal portion of the aortic arch adjacent to the left subclavian artery, a first branch stent-graft prosthesis configured to be positioned within the brachiocephalic artery and a second branch stent-graft prosthesis configured to be positioned in one of the left common carotid and the left subclavian artery. When deployed, a proximal end of the first branch stent-graft prosthesis is disposed within a lumen of the proximal aortic stent-graft prosthesis to proximally displace the ostium of the brachiocephalic artery. When deployed, a proximal end of the distal aortic stent-graft prosthesis is disposed within the distal end of the proximal aortic stent-graft prosthesis to form an overlap between the proximal and distal aortic stent-graft prostheses. The overlap is relatively increased by the first branch stent-graft prosthesis proximally displacing the ostium of the brachiocephalic artery.

In an aspect, the present disclosure provides a cartridge that is pre-loaded with a surgical mesh, where the cartridge is configured to be inserted into an internal body cavity of a subject and for the surgical mesh to be deployed while the cartridge is in the internal body cavity of the subject. In another aspect, the present disclosure provides a surgical robotic system comprising a set of sensors embedded thereon, wherein the surgical robotic system is configured to perform a surgical hernia repair procedure with increased consistency.

Stents comprising a first region and a second region are provided, where at least the second region comprises one or more phase transforming cellular materials configured to move the outlet between an open configuration and a closed configuration in response to certain triggers. Such stents can also comprise one or more analog for a shape memory alloy (ASMA) unit cells on an inner surface of the first region such that, in response to resistive forces, the ASMA unit cells exert controllable motion to clear the stent. Methods of treatment of cancer, jaundice, and other diseases are also provided.

A stent graft for placement in a vessel of a patient, the stent graft that has a tubular body of graft material, the tubular body having a proximal inflow end, a distal outflow end, a main lumen therethrough, a longitudinal access, and a sidewall from the first end to the second end. At least one stent is along the length of the tubular body. One or more shaped recesses are formed of a concave or recessed portion of graft material that extends into the lumen of the stent graft. A fenestration is in the recessed portion with a fenestration and an internal branch extends from the or each fenestration toward the proximal end of the tubular body of graft material. The internal branch may have a tubular portion and a funnel portion, wherein the tubular portion extends into the main lumen and the enlarged funnel portion is attached to sidewall and forms the at least one shaped recess.

Disclosed is a false lumen closure assembly for closing a false lumen in a body vessel including a compressed false lumen occluder, a carrier catheter and a retractable sheath. The compressed false lumen occluder includes a stent graft including at least one occlusive barrier across the stent graft to occlude blood flow through an interior of the stent graft. The carrier catheter carries the false lumen occluder and extends from a proximal end proximal of the false lumen occluder to a distal end distal of the false lumen occluder, and passes the false lumen occluder exteriorly of the stent graft. The compressed false lumen occluder and at least part of the carrier catheter are disposed in a lumen of the retractable sheath.

Apparatus and methods are described herein for use in the delivery and deployment of a prosthetic mitral valve into a heart. In some embodiments, an apparatus includes a catheter assembly, a valve holding tube and a handle assembly. The valve holding tube is releasably couplable to a proximal end portion of the catheter assembly and to a distal end portion of the handle assembly. The handle assembly includes a housing and a delivery rod. The delivery rod is configured to be actuated to move distally relative to the housing to move a prosthetic heart valve disposed within the valve holding tube out of the valve holding tube and distally within a lumen of the elongate sheath of the catheter assembly. The catheter assembly is configured to be actuated to move proximally relative to the housing such that the prosthetic valve is disposed outside of the lumen of the elongate sheath.

A braided vaso-occlusive member formed out of first plurality of filaments interwoven with a second plurality of filaments, wherein filaments of the first plurality are helically wound in a first rotational direction along an elongate axis of the braided member, and filaments of the second plurality are wound in a second rotational direction opposite the first rotational direction, such that filaments of the first plurality cross over and/or under filaments of the second plurality at each of a plurality cross-over locations axially spaced along the elongate axis of the braided member, wherein at each cross-over location, the filaments of the first plurality cross over at least two consecutive filaments of the second plurality, then cross under only a single filament of the second plurality, and then cross over at least two additional consecutive filaments of the second plurality.

A double-layer lumen stent (100) includes a main body lumen stent (10) and an outer-layer skirt stent (20) surrounding an outer wall of the main body lumen stent (10); the outer-layer skirt stent (20) includes a support structure (21) and a cover layer (22) arranged on the support structure (21); one end of the outer-layer skirt stent (20) is connected to the outer wall of the main body lumen stent (10); the other end of the outer-layer skirt stent (20) is an opening structure (24) composed of the support structure (21); and the cover layer (22) is formed into an oblique cut shape at an edge of the opening structure (24). In the double-layer lumen stent (100), when a clinician releases the double-layer lumen stent (100) at a human tissue such as a vessel through a delivery device, constraint from the cover layer (22) to the opening structure (24) of the outer-layer skirt stent (20) can be reduced, and the adhesion between the cover layer (22) at the opening structure (24) on the outer-layer skirt stent (20) and the main body lumen stent (10) is reduced, thereby reducing release resistance to the outer-layer skirt stent (20) during the release process of the double-layer lumen stent (100).