The present disclosure relates to novel sulfonimidamide compounds and related compounds and their use in treating a disorder responsive to modulation of cytokines such as IL-1β and IL-18, modulation of NLRP3 or inhibition of the activation of NLRP3 or related components of the inflammatory process.

The present disclosure provides methods for producing N-(fluorosulfonyl)azoles, sulfonyldiazoles, or related derivatives thereof, and the related products including N-(fluorosulfonyl)azoles, sulfonyldiazoles, and related derivatives thereof. For example, an N-(fluorosulfonyl)azole is obtained by reaction of sulfuryl fluoride with an azoles, an azolate salt, an N-silylazole, or a combination thereof. Symmetric and asymmetric sulfonyldiazoles are obtained by further reaction of such an N-(fluorosulfonyl)azole with azoles, azolate salts, or N-silylazoles. A sulfonyldiazole can be also produced by reacting sulfuryl fluoride with an azole, an N-silylazole, or a combination thereof in one pot.

The present disclosure provides methods for producing N-(fluorosulfonyl)azoles, sulfonyldiazoles, or related derivatives thereof, and the related products including N-(fluorosulfonyl)azoles, sulfonyldiazoles, and related derivatives thereof. For example, an N-(fluorosulfonyl)azole is obtained by reaction of sulfuryl fluoride with an azoles, an azolate salt, an N-silylazole, or a combination thereof. Symmetric and asymmetric sulfonyldiazoles are obtained by further reaction of such an N-(fluorosulfonyl)azole with azoles, azolate salts, or N-silylazoles. A sulfonyldiazole can be also produced by reacting sulfuryl fluoride with an azole, an N-silylazole, or a combination thereof in one pot.

The present invention relates to a process for preparing crystalline methyl N-[2-[[[1-(4-chlorophenyl)-1H-pyrazol-3-yl]oxy]methyl]phenyl]-N-methoxycarbamate (I), comprising a) reacting a compound of formula II ##STR00001## with an alkylating agent in the presence of a base in the presence of a polar solvent selected from alcohols and ketons; b) the addition of water.

The present invention relates to a process for preparing crystalline methyl N-[2-[[[1-(4-chlorophenyl)-1H-pyrazol-3-yl]oxy]methyl]phenyl]-N-methoxycarbamate (I), comprising a) reacting a compound of formula II ##STR00001## with an alkylating agent in the presence of a base in the presence of a polar solvent selected from alcohols and ketons; b) the addition of water.

The present invention provides new arylsulfonamide compounds having the general formula (I) ##STR00001##
wherein L, R.sup.1, R.sup.2, R.sup.3 and R.sup.4 are as described herein, compositions including the compounds, processes of manufacturing the compounds and methods of using the compounds.

The present invention provides new arylsulfonamide compounds having the general formula (I) ##STR00001##
wherein L, R.sup.1, R.sup.2, R.sup.3 and R.sup.4 are as described herein, compositions including the compounds, processes of manufacturing the compounds and methods of using the compounds.

The present invention relates to a process for preparing crystalline methyl N-[2-[[[1-(4-chlorophenyl)-1H-pyrazol-3-yl]oxy]methyl]phenyl]-N-methoxycarbamate (I), comprising a) reacting a compound of formula II

##STR00001## with an alkylating agent in the presence of a base in the presence of a polar solvent selected from alcohols and ketons; b) the addition of water.

The object of present invention is to provide pyrazolonated compounds with high stability.

The object can be solved by a pyrazolone compound represented by the following formula (1):

##STR00001## wherein R.sup.1 is an electron withdrawing group selected from the group consisting of one or more selected from the group consisting of a halogen atom, a nitro group, a cyano group, a haloalkyl group having 1 to 10 carbon atoms, a perfluoropolyether group having 2 to 10 carbon atoms, and the following formulas (2) to (7):

##STR00002## R.sup.2 is a hydrocarbon group having 1 to 1000 carbon atoms, which may contain a heteroatom, and n is an integer of 0 to 2.

The object of present invention is to provide pyrazolonated compounds with high stability.

The object can be solved by a pyrazolone compound represented by the following formula (1):

##STR00001## wherein R.sup.1 is an electron withdrawing group selected from the group consisting of one or more selected from the group consisting of a halogen atom, a nitro group, a cyano group, a haloalkyl group having 1 to 10 carbon atoms, a perfluoropolyether group having 2 to 10 carbon atoms, and the following formulas (2) to (7):

##STR00002## R.sup.2 is a hydrocarbon group having 1 to 1000 carbon atoms, which may contain a heteroatom, and n is an integer of 0 to 2.