Patent classifications
C
CHEMISTRY; METALLURGY
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C07
ORGANIC CHEMISTRY
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C07D
HETEROCYCLIC COMPOUNDS
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231/00
Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
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C07D231/02
not condensed with other rings
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C07D231/10
having two or three double bonds between ring members or between ring members and non-ring members
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C07D231/14
with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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C07D231/30
attached in positions 3 and 5
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C07D231/36
with hydrocarbon radicals, substituted by hetero atoms, attached in position 4
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C07D231/36

Small-molecule inhibitors targeting G-protein-coupled Rho guanine nucleotide exchange factors
09951024 · 2018-04-24 · ·

Provided are inhibitors of Rho GTPase activation, and, in particular, compounds that inhibit RhoA activation by an RhoGEF. Also provided are related pharmaceutical compositions and methods. Also provided are methods of inhibiting Rho GTPase activation. Also provided are methods of screening for compounds that inhibit Rho GTPase activation by a RhoGEF.