An infusion filter design combines a fluid infusion device and a blood filtration device that filter blood during a thrombolysis procedure while allowing for complete filter removal on procedure completion. In one embodiment, a wire comprises a proximal, non-infusible length that extends partially outside of the patient and within the vein. The wire further comprises an infusible length distally from the non-infusible length that is extends within the vein so as to be placed at the section of the vein requiring medication. The wire also comprises a distal filter component at a distal end of the wire that is employed to filter the blood in the event that during the period that clot is dissolved it migrates toward the central circulation.

The invention relates to an arrangement and a software-based application for modifying an internal eye pressure in vivo, having modulating means for modifying the internal eye pressure and sensor means for capturing the internal eye pressure in vivo, and enabling easily operated and quickly reacting changes to the internal eye pressure while avoiding the disadvantages of the prior art, proposing that the modulating means are implemented for modifying the internal eye pressure as a function of the internal eye pressure captured by the sensor means.

Some target anatomies within the ear, nose and/or throat of a patient may be difficult to access and treat. To provide a means of treating such target anatomies over time, drug delivery devices that are sized to be positioned within a naturally occurring or man-made anatomical cavity or passageway are preloaded with active agent(s). The drug delivery devices are affixed directly to, or in the vicinity of, a target anatomy. Once affixed, the drug delivery devices are configured to deliver active agent(s) at desired dosage(s) to the target anatomy through controlled elution of the active agent(s) as various structural features of the drug delivery devices are bio-eliminated.

Object of the present invention is a drug delivery system comprising a decellularized corneal stroma scaffold having dispersed within and/or bound to its surface microparticles containing at least one pharmaceutically active molecule dispersed in a matrix having a composition consisting for at least 70% of polylactic co-glycolic acid (PLGA).

A medical device comprises a substrate (10) defining a major surface (9) defining a plane, including a plurality of first struts (14) along a first direction interconnected with a plurality of second struts (12) extending along a second direction not parallel with the first direction, wherein widths (11) of the second struts as measured along the major surface are larger than thicknesses of the second struts as measured perpendicular to the major surface such that when the substrate is stretched in the first direction, intermediate sections (15) of the second struts (12) rotate relative to the first struts (14) and the intermediate sections of the second struts bend out of the plane of the major surface. The medical device is operable to extend and/or retract elements suitable for a particular purpose. The elements are extended and/or retracted in response to a stress applied by way of stretching and/or retracting the device, among other methods. The elements may remain extended and/or retracted or may recoil back to an initial position upon the removal of the force. In various embodiments, the elements are used to treat or deliver treatment to a target site within a body.

The present invention is an inflatable balloon which is enclosed by an expandable cover which becomes increasingly porous/permeable during expansion. The balloon is coated or enclosed with a matrix which contains a pharmaceutically active agent. During expansion of the balloon, the pharmaceutically active agent is released or extruded through the expandable cover into a body cavity such as an artery or vein. The present invention also provides for a method of treating a disease or condition by delivering the inflatable balloon to a particular body cavity.

A venous valve prosthetic implant for treatment of venous disease may include an expandable anchoring frame, a valve seat attached to the anchoring frame, a ball retention member attached to the anchoring frame, and a ball disposed within the lumen of the anchoring frame, between the valve seat and the ball retention member. The anchoring frame may include a first end, a second end, and a middle valve portion, where the middle valve portion expands to a smaller diameter than a diameter of either the first end or the second end. The ball may move back and forth within the middle valve portion, between a fully open position and a fully closed position.

A medical device includes a body defining an exterior surface, and a coating including a therapeutic agent-containing nanoparticle disposed on the exterior surface of the medical device. The nanoparticle may include a brush-arm star polymer. The therapeutic agent may be paclitaxel.

A method and apparatus is provided for creating a modified tissue graft, wherein an anatomical site at which the modified tissue graft is to be placed is identified, desired characteristics for the modified tissue graft are identified based at least upon the anatomical site, one or more types of graft modifications and regions of the tissue graft to be modified are identified to achieve the desired characteristics; and at least a first area and a second area of the exterior surface of the tissue graft are modified by compressing, cutting and/or removing one or more portions thereof to create first designed surface features which cause the tissue graft to have first characteristics in the first area and second designed surface features which cause the tissue graft to have second characteristics in the second area.

Kit includes coaptation aid and fixation system for repair of leaflets of a heart valve. Coaptation aid includes coaptation catheter having an expandable member at a distal end thereof adapted to be introduced to a left ventricular outflow tract of a heart via a retrograde approach. Expandable member has a delivery configuration with a reduced cross-dimension and a deployed configuration with an expanded cross-dimension adapted to contact a ventricular side of a first leaflet of a heart valve and position the first leaflet generally proximate a coapting configuration with a second leaflet. Fixation system includes a delivery catheter having a distal end, and a fixation device removably coupled to the distal end of the delivery catheter and is adapted to couple the first leaflet to the second leaflet of the heart valve. Methods for fixation of native leaflets of a heart valve using a coaptation aid also disclosed.