Methods for making a magnesium biodegradable stent for medical implant applications, using magnesium foil or pure magnesium or magnesium alloys that are biodegradable and performing a lithographic technique to configure the features and dimensions of the magnesium foil, and rolling the magnesium foil to form a cylinder.

A coated medical device (10) including a structure (12) adapted for introduction into a passage or vessel of a patient. The structure is formed of preferably a non-porous base material (14) having a bioactive material layer (18) disposed thereon. The medical device is preferably an implantable stent or balloon (26) of which the bioactive material layer is deposited thereon. The stent can be positioned around the balloon and another layer of the bioactive material posited over the entire structure and extending beyond the ends of the positioned stent. The ends of the balloon extend beyond the ends of the stent and include the bioactive material thereon for delivering the bioactive material to the cells of a vessel wall coming in contact therewith. The balloon further includes a layer of hydrophilic material (58) positioned between the base and bioactive material layers of the balloon.

Methods for making a magnesium biodegradable stent for medical implant applications, using magnesium foil or pure magnesium or magnesium alloys that are biodegradable and performing a lithographic technique to configure the features and dimensions of the magnesium foil, and rolling the magnesium foil to form a cylinder.

A coated medical device (10) including a structure (12) adapted for introduction into a passage or vessel of a patient. The structure is formed of preferably a non-porous base material (14) having a bioactive material layer (18) disposed thereon. The medical device is preferably an implantable stent or balloon (26) of which the bioactive material layer is deposited thereon. The stent can be positioned around the balloon and another layer of the bioactive material posited over the entire structure and extending beyond the ends of the positioned stent. The ends of the balloon extend beyond the ends of the stent and include the bioactive material thereon for delivering the bioactive material to the cells of a vessel wall coming in contact therewith. The balloon further includes a layer of hydrophilic material (58) positioned between the base and bioactive material layers of the balloon.

Self-expanding, tubular (tapered or constant diameter), oval or elliptical (not circular) airway stents suitable for placement under open or minimally invasive approaches within patients of various sizes and of various species, and methods for their placement in a tracheobronchial tree of a patient. The airway stent may be provided in various lengths and have an oval or elliptical cross-sectional shape that is either constant or variable in both short axis dimensions. The airway stents are particularly suited for treating patients with large airway obstructions in whom the natural airway cross-sectional dimensions are oval or elliptical rather than circular. The airway stent allows for more anatomic filling of the natural airway lumen, reduces the need to oversize the airway stent diameter and therefore reduces subsequent stent fatigue and fracture, and improves stent-tracheal wall contact to minimize gaps that lead to mucus trapping and chronic infections with subsequent tissue ingrowth and airway obstruction.

The invention relates to an implantable medical device (10) comprising:a variable-volume fluid reservoir which is able to deform under the effect of a variation in atmospheric pressure,an inflatable element (3) in fluid connection with the reservoir (5),an actuator (8) which is suitable for selectively varying the volume of the reservoir (5), anda data processing and control unit (200) which is configured to command a selective variation in the volume of the reservoir (5) by the actuator (8) and to carry out, if an atmospheric pressure estimation exceeds at least one atmospheric pressure threshold and/or if an altitude estimation exceeds at least one altitude threshold, at least one of the steps of: a) commanding. by means of the unit (200), at least one withdrawal of a volume of fluid from the inflatable element (3) to the reservoir (5) by means of the actuator (8); b) commanding, by means of the unit (200), at least one injection of a volume of fluid from the reservoir (5) to the inflatable element (3) by means of the actuator (8).

Described is a system and method for designing and fabricating idealized implants any hollowed anatomical structures. It includes a system and a method for obtaining and segmenting three-dimensional image data to segment an area of interest for a plurality of subjects in a population. The system and method use cross-sectional areas calculated at a plurality of discrete or relative locations to determine the relative shape of a hollowed anatomical structure, and statistical methods to find an optimal subject in a population. An idealized implant is then produced and manufactured based on the optimal subject model for a population.