The present invention relates to polyurethane-urea elastomers with exceptional mechanical properties and enhanced elasticity based on molecular structure analysis. The present invention involves the synthesis of a polyurethane-urea elastomer using a combination of commercially available materials: (1) polyols with ultralow unsaturation and narrow polydispersity, (2) diisocyanates with symmetric steric conformation, and (3) bulky diamines between functional groups. The preparation method for the novel polyurethane-urea is disclosed. The subject elastomers have the highest reported elongation-at-break among known polyurethane elastomers.

The polyisocyanate composition contains a polyisocyanate having an isocyanatomethyl group, and a 1-nylon type polymer. The ratio of the mass of the amide bond in the polyisocyanate composition with respect to the mass of the isocyanate group in the polyisocyanate composition is 8000 ppm or less.

The present invention relates to the discovery of new class of hydrolysable amino acid derivatives and absorbable polyester amides, polyamides, polyepoxides, polyureas and polyurethanes prepared therefrom. The resultant absorbable polymers are useful for drug delivery, tissue engineering, tissue adhesives, adhesion prevention, bone wax formulations, medical device coatings, stents, stent coatings, highly porous foams, reticulated foams, wound care, cardiovascular applications, orthopedic devices, surface modifying agents and other implantable medical devices. In addition, these absorbable polymers should have a controlled degradation profile.

The present invention relates to the discovery of new class of hydrolysable amino acid derivatives and absorbable polyester amides, polyamides, polyepoxides, polyureas and polyurethanes prepared therefrom. The resultant absorbable polymers are useful for drug delivery, tissue engineering, tissue adhesives, adhesion prevention, bone wax formulations, medical device coatings, stents, stent coatings, highly porous foams, reticulated foams, wound care, cardiovascular applications, orthopedic devices, surface modifying agents and other implantable medical devices. In addition, these absorbable polymers should have a controlled degradation profile.

This invention relates to hydrophilic polymer compositions and a preferred application therefore, viz., hydrophilic medical device coatings. The hyaluronic acid hyaluronon by itself or modified as described herein advantageously reacts with compositions disclosed in U.S. Pat. No. 7,776,956 to produce hydrophilic compositions and coatings particularly useable with medical devices.