Provided herein are polymeric α-hydroxy aldehyde or α-hydroxy ketone reagents which can be conjugated to amine-containing compounds to form stable conjugates in a single-step reaction. In selected embodiments, the polymeric reagent itself incorporates an internal proton-abstracting (basic) functional group, to promote more efficient reaction. The substituent is appropriately situated, via a linker if necessary, to position the group for proton abstraction, preferably providing a 4- or 5-bond spacing between the abstracting atom and the hydrogen atom on the α-carbon. Also provided are methods of using the reagents and stable, solubilized conjugates of the reagents with biologically active compounds. In preferred embodiments, the polymeric component of the reagent or conjugate is a polyethylene glycol.

A method of demulsifying crude oil, said method comprising the step of reacting an amount of crude oil with a polyester demulsifier, therein the demulsifier is used in quantities from 0.0001% to 5% (1-50,000 ppm), preferably 0.0005% to 2% (5-20,000 ppm), more preferably 0.0008% to 1% (8-10,000 ppm) and most preferably 0.001 to 0.1 wt. % polymer (10-1,000 ppm) related to the oil fraction of the utilized emulsion.

The present invention relates to a process for the synthesis of partially and fully fluorinated polyether (PFPE) polymers comprising cyclic moieties in the backbone chain, to PFPE polymers obtained therefrom and to the use of said PFPE polymers as intermediate compounds for the manufacture of additives for plastic and glass coating.

The present invention relates to a novel process for the synthesis of (per)fluoropolyether polymers, to certain novel (per)fluoropolyether polymers. The present invention also relates to the use of the (per)fluoropolyether polymers thus obtained as intermediate compounds for the manufacture of further polymers suitable for use as lubricants, notably for magnetic recording media (MRM).

This disclosure relates to polymersomes comprising a crosslinked polymer and their use as drug delivery vehicles. Specifically, polymersomes comprising a polymer of Formula I: ##STR00001##
wherein each R is independently C.sub.1-6 alkyl; and n is an integer between 1 and 50.

A method of demulsifying crude oil, said method comprising the step of reacting an amount of crude oil with a polyester demulsifier, therein the demulsifier is used in quantities from 0.0001% to 5% (1-50,000 ppm), preferably 0.0005% to 2% (5-20,000 ppm), more preferably 0.0008% to 1% (8-10,000 ppm) and most preferably 0.001 to 0.1 wt. % polymer (10-1,000 ppm) related to the oil fraction of the utilized emulsion.

Provided herein are polymeric -hydroxy aldehyde or -hydroxy ketone reagents which can be conjugated to amine-containing compounds to form stable conjugates in a single-step reaction. In selected embodiments, the polymeric reagent itself incorporates an internal proton-abstracting (basic) functional group, to promote more efficient reaction. The substituent is appropriately situated, via a linker if necessary, to position the group for proton abstraction, preferably providing a 4- or 5-bond spacing between the abstracting atom and the hydrogen atom on the -carbon. Also provided are methods of using the reagents and stable, solubilized conjugates of the reagents with biologically active compounds. In preferred embodiments, the polymeric component of the reagent or conjugate is a polyethylene glycol.

Provided herein are polymeric -hydroxy aldehyde or -hydroxy ketone reagents which can be conjugated to amine-containing compounds to form stable conjugates in a single-step reaction. In selected embodiments, the polymeric reagent itself incorporates an internal proton-abstracting (basic) functional group, to promote more efficient reaction. The substituent is appropriately situated, via a linker if necessary, to position the group for proton abstraction, preferably providing a 4- or 5-bond spacing between the abstracting atom and the hydrogen atom on the -carbon. Also provided are methods of using the reagents and stable, solubilized conjugates of the reagents with biologically active compounds. In preferred embodiments, the polymeric component of the reagent or conjugate is a polyethylene glycol.

This disclosure relates to polymersomes comprising a crosslinked polymer and their use as drug delivery vehicles. Specifically, polymersomes comprising a polymer of Formula I:

##STR00001##

wherein each R is independently C.sub.1-6 alkyl; and n is an integer between 1 and 50.

A chromene compound having at least one indenonaphthopyran moiety which has a group forming a spiro ring together with the 13-position carbon atom and further an oligomer chain group selected from a polyalkylene oxide oligomer chain group having at least three recurring units and a polyester oligomer chain group having at least three recurring units, represented by the following formula and having reduced matrix dependence:

##STR00001##

wherein R.sup.1 and R.sup.2 are each a group which may have an oligomer chain group, the ring Z bonded to the 13-position carbon atom of the chromene compound is a Spiro ring group, and R.sup.3 and R.sup.4 are each an aryl group or heteroaryl group which may have an oligomer chain group.

Preferably, the chromene compound has at least one oligomer chain group in the molecule.