The present invention aims to provide a photochromic compound capable of exhibiting photochromic properties regardless of matrix, and the compound is stably dispersed without aggregation in a process of molding (curing) an optical base material. According to the present invention, a polymer photochromic compound, which has a block polymeric group of an oligomeric chain group having relatively favorable compatibility with a solid matrix and an oligomeric chain group having poor compatibility with a solid matrix, forms a nano- to micro-phase separation structure in a solid matrix. The compound does not rely on the solid matrix, its dispersibility is improved and aggregation is prevented or reduced, whereby excellent photochromic properties can be exhibited.

The subject matter of this invention relates to hydrogel compositions and, more particularly, to hydrogel compositions comprising block copolymers (BCPs) capable of self-assembly into nanoparticles for the delivery and controlled release of therapeutic cargos.

A viscosity regulating composition and its method of manufacture. The composition comprises a mixture of (a) a branched polymer having the formula [M]-[(A.sup.1O)-L.sup.1-(A.sup.1O)—R.sup.1].sub.n, wherein M is polybranched hydrophobe; A.sup.1O is a polyoxyalkylene unit; L.sup.1 is an aliphatic linking segment or an aromatic linking segment each having at least two hydroxyl reactive linking groups; and R.sup.1 is an aliphatic end unit or aromatic end unit having 6 to 32 carbon atoms; n ranges from 3 to 6; and (b) a polymer having the formula R.sup.2-(A.sup.2O)-L.sup.2-(A.sup.2O)—R.sup.2, wherein (A.sup.2O) is a polyoxyalkylene unit, L.sup.2 is a aliphatic linking segment or an aromatic linking segment, and R.sup.2 is a aliphatic unit or an aromatic unit each having 6 to 32 carbon atoms.

The invention relates to an aqueous dispersion of a carboxyl-functional, unsaturated polyester containing a perfluoropolyether block prepared by the following steps: a) subjecting a carboxyl-terminated perfluoropolyether C to a reaction with an ethylenically unsaturated epoxy-functional compound D in the presence of compound E, which is a carboxylic acid or anhydride with functionality of at least 2, to obtain carboxyl-functional, unsaturated polyester F, b) neutralizing carboxyl-functional, unsaturated polyester F with a neutralizer G and dispersing it in water. The dispersion can be used to prepare a waterborne, UV-curable coating composition and used for easy-clean coatings for various substrates.

The invention relates to a method for attenuating vibrations and/or shocks, said method comprising providing a damper assembly which comprises a moving part and a supramolecular polymer in contact with said moving part, and exposing said moving part to said vibrations and/or shocks, wherein said supramolecular polymer is obtained by reacting: at least one first polymer [polymer (P1)] comprising a polymer chain [chain (R)] consisting of a plurality of non-ionisable recurring units [units (U)], said polymer (P1) having two chain ends (E1, E1′), each end comprising at least one ionisable acid group, and at least one second polymer [polymer (P2)] comprising a polymer chain [chain (R)] consisting of a plurality of recurring units [units (U)], said chain (R) being equal to or different from that of polymer (P1), and said polymer (P2) having two chain ends (E2, E2′), each end comprising at least one ionisable amino group.

Disclosed are a novel monofunctional polyethylene glycol (PEG) and derivatives thereof. More particularly, one terminal of each of the monofunctional polyethylene glycol and derivatives thereof is modified with a siloxy group. The novel monofunctional polyethylene glycol (PEG) offers an alternative to methoxy polyethylene glycol.

Provided herein are polymeric α-hydroxy aldehyde or α-hydroxy ketone reagents which can be conjugated to amine-containing compounds to form stable conjugates in a single-step reaction. In selected embodiments, the polymeric reagent itself incorporates an internal proton-abstracting (basic) functional group, to promote more efficient reaction. The substituent is appropriately situated, via a linker if necessary, to position the group for proton abstraction, preferably providing a 4- or 5-bond spacing between the abstracting atom and the hydrogen atom on the α-carbon. Also provided are methods of using the reagents and stable, solubilized conjugates of the reagents with biologically active compounds. In preferred embodiments, the polymeric component of the reagent or conjugate is a polyethylene glycol.

This disclosure provides improved lipid-based compositions, including lipid nanoparticle compositions, and methods of use thereof for delivering agents in vivo including nucleic acids and proteins. These compositions are not subject to accelerated blood clearance and they have an improved toxicity profile in vivo.

A viscosity regulating composition and its method of manufacture. The composition comprises a mixture of (a) a branched polymer having the formula [M]-[(A.sup.1O)-L.sup.1-(A.sup.1O)—R.sup.1].sub.n, wherein M is polybranched hydrophobe; A.sup.1O is a polyoxyalkylene unit; L.sup.1 is an aliphatic linking segment or an aromatic linking segment each having at least two hydroxyl reactive linking groups; and R.sup.1 is an aliphatic end unit or aromatic end unit having 6 to 32 carbon atoms; n ranges from 3 to 6; and (b) a polymer having the formula R.sup.2-(A.sup.2O)-L.sup.2-(A.sup.2O)—R.sup.2, wherein (A.sup.2O) is a polyoxyalkylene unit, L.sup.2 is a aliphatic linking segment or an aromatic linking segment, and R.sup.2 is a aliphatic unit or an aromatic unit each having 6 to 32 carbon atoms.

Di(amido(alkyl)phenol) compounds and upgraded molecular weight polymers made from such compounds have particular utility in coating compositions, especially for use on food and beverage contact substrates that are formed into or will be formed into containers or container components.