The disclosure pertains to radiopaque, unsaturated multi-arm polymers that comprise a plurality of hydrophilic polymer arms having end moieties comprising one or more radiopaque halogen groups and one or more unsaturated groups, the end moieties linked to the hydrophilic polymer arms though an ester or an amide linkage. In some embodiments, the disclosure pertains to systems for forming hydrogels, which systems comprise (a) a polyamino compound and (b) a radiopaque, unsaturated multi-arm polymer that comprises a plurality of hydrophilic polymer arms having end moieties comprising one or more radiopaque halogen groups and one or more unsaturated groups, the end moieties linked to the hydrophilic polymer arms though an ester or an amide linkage, wherein the one or more unsaturated groups are reactive with the amino groups of the polyamino compound. Other embodiments pertain to methods of treatment using such systems and to hydrogels formed from such systems.

The present invention suggests novel inorganic binder formulations and the use of these formulations for the production of acid and heat-resistant construction products.

This disclosure provides improved lipid-based compositions, including lipid nanoparticle compositions, and methods of use thereof for delivering agents in vivo including nucleic acids and proteins. These compositions are not subject to accelerated blood clearance and they have an improved toxicity profile in vivo.

This disclosure provides improved lipid-based compositions, including lipid nanoparticle compositions, and methods of use thereof for delivering agents in vivo including nucleic acids and proteins. These compositions are not subject to accelerated blood clearance and they have an improved toxicity profile in vivo.

The present invention relates to radiation curable compositions (A) comprising(a) at least one photoinitiator compound of formula (I) wherein Q is the residue of a hydroxy compound having 1 to 6 hydroxyl groups, and wherein x is a number that is at least 1 but no greater than the number of hydroxyl groups originally present in said hydroxy compound;(b) at least one ethylenically unsaturated compound selected from monomers (b1) and/or from oligomers (b2); and(c) optionally, at least one co-synergist which preferably is an amino co-synergist. The present invention further relates to photoinitiator compounds(a) and their preparation. ##STR00001##

Described herein is a pigmented aqueous basecoat material including a polyether-based reaction product which is preparable by reaction of (a) at least one cyclic tetracarboxylic dianhydride having an aliphatic, aromatic, or araliphatic radical X bridging the two anhydride groups with (b) at least one polyether of the general structural formula (II)

##STR00001## in which R is a C.sub.3 to C.sub.6 alkylene radical and n is selected accordingly such that the polyether (b) possesses a number-average molecular weight of 500 to 5000 g/mol, the components (a) and (b) being used in the reaction in a molar ratio of 0.7/2.3 to 1.6/1.7 and the resulting reaction product possessing an acid number of 5 to 80 mg KOH/g. Also described herein is a reaction product of specific dianhydrides and a polyether, and the use of the pigmented aqueous basecoat material or the reaction product.

The present invention relates to micellar nanocomplexes and a method of forming the same. The micellar nanocomplex comprises a micelle and an agent encapsulated within said micelle, where the micelle comprises a polymer-flavonoid conjugate, wherein said polymer is bonded to the B ring of said flavonoid. The micellar nanocomplex may have useful applications as a drug-delivery system.

A composition including a perfluoropolyether compound, and an organic solvent configured to dissolve or disperse the perfluoropolyether compound, wherein the perfluoropolyether compound includes a first end and a second end facing each other and a perfluoropolyether moiety disposed between the first end and the second end, wherein the first end includes an organic group having 6 or more carbon atoms, and wherein the second end includes a hydrolysable silicon-containing residual group.

A pigmented aqueous basecoat material is disclosed. The pigmented aqueous basecoat material includes a polyether-based reaction product which is preparable by a reaction of trimesic acid with at least one polyether of the general structural formula (I)

##STR00001##

R is a C.sub.3 to C.sub.6 alkylene radical and n is selected accordingly such that the at least one polyether possesses a number-average molecular weight of 500 to 5000 g/mol. The trimesic acid and the at least one polyether are used in the reaction in a molar ratio of 0.7/2.3 to 1.6/1.7 and the resulting reaction product possesses an acid number of 10 to 50 mg KOH/g.

Provided herein are polymeric -hydroxy aldehyde or -hydroxy ketone reagents which can be conjugated to amine-containing compounds to form stable conjugates in a single-step reaction. In selected embodiments, the polymeric reagent itself incorporates an internal proton-abstracting (basic) functional group, to promote more efficient reaction. The substituent is appropriately situated, via a linker if necessary, to position the group for proton abstraction, preferably providing a 4- or 5-bond spacing between the abstracting atom and the hydrogen atom on the -carbon. Also provided are methods of using the reagents and stable, solubilized conjugates of the reagents with biologically active compounds. In preferred embodiments, the polymeric component of the reagent or conjugate is a polyethylene glycol.