A viscosity regulating composition and its method of manufacture. The composition comprises a mixture of (a) a branched polymer having the formula [M]-[(A.sup.1O)-L.sup.1-(A.sup.1O)R.sup.1].sub.n, wherein M is polybranched hydrophobe; A.sup.1O is a polyoxyalkylene unit; L.sup.1 is an aliphatic linking segment or an aromatic linking segment each having at least two hydroxyl reactive linking groups; and R.sup.1 is an aliphatic end unit or aromatic end unit having 6 to 32 carbon atoms; n ranges from 3 to 6; and (b) a polymer having the formula R.sup.2-(A.sup.2O)-L.sup.2-(A.sup.2O)R.sup.2, wherein (A.sup.2O) is a polyoxyalkylene unit, L.sup.2 is a aliphatic linking segment or an aromatic linking segment, and R.sup.2 is a aliphatic unit or an aromatic unit each having 6 to 32 carbon atoms.

In some aspects, a system for forming a hydrogel composition is described that comprises (a) a multifunctional cyclic carbonate compound and (b) a radiopaque, reactive polymer that comprises a plurality of amino groups that are reactive with the multifunctional cyclic carbonate groups of the multifunctional cyclic carbonate compound. In other aspects, a radiopaque crosslinked hydrogel composition is described that comprises a crosslinked reaction product of a multifunctional cyclic carbonate compound and a radiopaque, reactive polymer that comprises a plurality of amino groups. In further aspects, a method of treatment is described that comprises administering to a subject a mixture that comprises a multifunctional cyclic carbonate compound and a radiopaque, reactive polymer that comprises a plurality of amino groups, wherein the mixture is administered under conditions such that the multifunctional cyclic carbonate compound and the radiopaque, reactive multi-arm polymer crosslink after administration.

In some aspects, the present disclosure pertains to systems for forming a crosslinked polymer composition, the systems comprising (a) an iodinated multifunctional compound comprising either a plurality of electron-rich dienophile-containing moieties or a plurality of electron-poor diene-containing moieties and (b) a multifunctional multi-arm polymer comprising either a plurality of electron-poor diene-containing moieties in the case where the iodinated multifunctional compound comprises a plurality of electron-rich dienophile-containing moieties or a plurality of electron-rich dienophile-containing moieties in the case where the iodinated multifunctional compound comprises a plurality of electron-poor diene-containing moieties, wherein the crosslinked polymer composition is formed by a cycloaddition reaction occurring between the iodinated multifunctional compound and the multifunctional multi-arm polymer. Other aspects of the present disclosure pertain to crosslinked networks formed by such systems and to methods of treatment using such systems.

The present invention relates to micellar nanocomplexes and a method of forming the same. The micellar nanocomplex comprises a micelle and an agent encapsulated within said micelle, where the micelle comprises a polymer-flavonoid conjugate, wherein said polymer is bonded to the B ring of said flavonoid. The micellar nanocomplex may have useful applications as a drug-delivery system.

This disclosure provides improved lipid-based compositions, including lipid nanoparticle compositions, and methods of use thereof for delivering agents in vivo including nucleic acids and proteins. These compositions are not subject to accelerated blood clearance and they have an improved toxicity profile in vivo.

Disclosed herein are glycidol-based polymers, nanoparticles, and methods related thereto useful for drug delivery. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.

Water-soluble supramolecular complexes formed from a water soluble block copolymer and at least one associative gelling adjuvant. The copolymer includes at least two blocks of polyethylene oxide and at least one block of polypropylene oxide. The adjuvant has a water solubility less than 0.5 g/100 ml at 20 C. When combined with water, the complexes form a transparent reversely thermo-reversible hydrogel or solution that may be repeatedly hydrated and dehydrated. The hydrogel exhibits improved gelling efficiency and enhanced solubility and/or stability for sparely soluble and insoluble pharmaceutical agents. The complexes are useful in a variety of pharmaceutical and cosmetic products and applications and may be combined with an effective amount of a cosmetic, medicament, or diagnostic in a solid dosage form.

The present invention discloses novel calibrants containing between 1 and 5 iodine atoms and methods of making them using linear polymers, hyperbranched polymers, and biological polymers (including but not limited to proteins and peptides.) Methods of using the calibrants are also disclosed, such as mass spectrometry. The novel calibrants disclosed herein have a more cost- and time-efficient synthesis than other calibrants.

The present invention includes an ultraviolet radiation absorbing polymer composition comprising the polymer compound of formula

##STR00001##

and compositions containing such an ultraviolet radiation absorbing polymer composition.

Provided herein are polymeric -hydroxy aldehyde or -hydroxy ketone reagents which can be conjugated to amine-containing compounds to form stable conjugates in a single-step reaction. In selected embodiments, the polymeric reagent itself incorporates an internal proton-abstracting (basic) functional group, to promote more efficient reaction. The substituent is appropriately situated, via a linker if necessary, to position the group for proton abstraction, preferably providing a 4- or 5-bond spacing between the abstracting atom and the hydrogen atom on the -carbon. Also provided are methods of using the reagents and stable, solubilized conjugates of the reagents with biologically active compounds. In preferred embodiments, the polymeric component of the reagent or conjugate is a polyethylene glycol.