A medical instrument in which an inorganic salt solid such as apatite into which a peptide hormone or the like is embedded is placed so that a metal or the like is coated therewith, in which the inorganic salt solid is provided by controlled delay co-precipitation or the like in an unstable supersaturated calcium phosphate solution, and the medical instrument is exposed to ionizing radiation at a dose sufficient for sterilization.

An intervertebral spacer is designed particularly for patients who are not candidates for total disc replacement. The spacer maintains disc height and prevents subsidence with a large vertebral body contacting surface area while substantially reducing recovery time by eliminating the need for bridging bone. The intervertebral spacer or fusion spacer includes a rigid spacer body sized and shaped to fit within an intervertebral space between two vertebral bodies. In one embodiment, the spacer body has two opposed metallic vertebral contacting surfaces, at least one fin extending from each of the vertebral contacting surfaces and configured to be positioned within slots cut into the two vertebral bodies. Holes, if present, cover less than 40 percent of the entire vertebral body contacting surfaces to provide increased bone ongrowth surfaces and to prevent subsidence.

An implant stabilizes two adjacent bones of a joint, while enabling a natural kinematic relative movement of the bones. Support components are connected to each bone of the joint, and a flexible core is interposed between them. The core and at least one of the support components are provided with a smooth sliding surface upon which the core and support component may slide relative to each other, enabling a corresponding movement of the bones. The surfaces may have a mating curvature, to mimic a natural movement of the joint. The core is resilient, and may bend or compress, enabling the bones to move towards each other, and or to bend relative to each other.

A bone structural device including a plurality of bone structural segments, wherein adjacent bone structural segments are pivotally connected to one another about a pivot axis, and the bone structural segments are expandable in height, which is in a direction generally parallel to the pivot axis.

Biphasic tissue constructs that include a scaffold having one or more channels, a vascular portion comprising a hydrogel at least partially disposed in the one or more channels, and a first bioactive growth factor and a second bioactive growth factor different from the first bioactive growth factor, the first bioactive growth factor localized to the scaffold and the second bioactive growth factor localized to the vascular portion. The first bioactive growth factor may be bone morphogenetic protein 2 (BMP2) peptide and the second bioactive growth factor may be vascular endothelial growth factor (VEGF) peptide.

Medical devices in accordance with various embodiments of the present invention employ one or more coaxial screw gear sleeve mechanisms. In various embodiments, coaxial screw gear sleeve mechanisms include a post with a threaded exterior surface and a corresponding sleeve configured to surround the post, the corresponding sleeve having a threaded interior surface configured to interface with the threaded exterior surface of the post and a geared exterior surface. A drive mechanism can be configured to interface with the geared exterior surface of the sleeve, causing the device to expand.

An expandable spinal implant includes a distal projection extending from only one side of the implant, ending in an anterior tip, the anterior portion and anterior tip defining an elongated distal end hook, which is wider than the proximal end. The distal end hook rotates around the spinal cord, aligning the implant with a desired pathway, then inserts into place in the disc space between the vertebrae. The elongated widened distal end hook provides a TLIF approach, distributes loads, provides anterior rim engagement, and creates lordosis.

A biodegradable joint implant comprises a joint scaffold and a film layer coated on the surface of the joint scaffold. The joint scaffold comprises a first anchor fixing, a second fixing and a flexible spacer, and the first anchor fixing and the second anchor fixing are respectively axially connected to opposite sides of the flexible spacer. The joint implant is made of biodegradable material, and the film layer contains at least one substance that can induce tissue growth. A method for preparing the joint implant and a joint replacement method using the joint implant are also provided.

Disclosed are systems, devices, methods and surgical procedures for altering and/or correcting the alignment of adjacent bones, including bones of the spine.

An allograft implant for fusing a sacroiliac joint. The allograft implant has a body with a graft window disposed therein. A bone growth factor is prepacked into the graft window at the manufacturing stage, prior to packaging and shipping. The implant with the prepacked bone growth factor is hermetically sealed in a package. The allograft implant may be classified as “human cells, tissues, and cellular and tissue-based product (HCT/P),” while the bone growth factor may be classified as a non-HCT/P. The implant may comprise a dissolvable or bioabsorbable membrane for retaining the growth factor inside the graft window. The graft window may comprise a scaffold for retaining a putty-like or a sponge-like bone growth factor.