A temozolomide compound according to formula (I)

##STR00001##

is described, wherein R.sup.1, L.sup.1, and X are defined herein. The temozolomide compound can be used to prepare polymers comprising temozolomide. Additionally, the polymers comprising temozolomide can be particularly useful in the treatment of certain diseases.

Di(amido(alkyl)phenol) compounds and upgraded molecular weight polymers made from such compounds have particular utility in coating compositions, especially for use on food and beverage contact substrates that are formed into or will be formed into containers or container components.

Cosmetic compositions, systems and methods for conferring responsive durable shaping of keratinous fibers employ at least one shape memory polymer that includes a three-armed branched polyethylene glycol (PEG) based polymer that is functionalized with one or more metal-coordination active groups. The shape memory polymer forms a crosslinked network coating on a substrate, for example a substrate selected from keratinous substrates, for example, hair. Hair coated with the shape memory polymer and treated with an oxidizing agent can be shaped, locked into shape, and reprogrammed by modulation of pH. The coated hair retains durable shaping properties through at least one shampoo treatment. The cosmetic compositions, systems and methods provide durable and reprogrammable durable shaping of the keratinous substrate, for example for styling hair.

A branched monodispersed polyethylene glycol represented by the formula (1):

##STR00001##

wherein X.sup.1 is a functional group that forms a covalent bond upon a reaction with a functional group present in a biofunctional molecule; n is an integer of 4 to 50, which represents number of repeating units of ethylene oxide units; and L.sup.1 represents a single bond, NH, -L.sup.2-(CH.sub.2).sub.m1 or -L.sup.2-(CH.sub.2).sub.m1-L.sup.3-(CH.sub.2).sub.2-, L.sup.2 represents an ether bond, an amide bond, an urethane bond or a single bond, L.sup.3 represents an ether bond, an amide bond or an urethane bond, and m1 and m2 represent each independently an integer of 1 to 5.

A hydrophilic polymer derivative having a cyclic benzylidene acetal linker represented by the following formula (1):

##STR00001##

wherein R.sup.1 and R.sup.6 are each independently a hydrogen atom or a hydrocarbon group; R.sup.2, R.sup.3, R.sup.4 and R.sup.5 are each independently an electron-withdrawing or electron-donating substituent or a hydrogen atom; X.sup.1 is a chemically reactive functional group; P is a hydrophilic polymer; s is 1 or 2, t is 0 or 1, and s+t is 1 or 2; w is an integer of 1 to 8; and Z.sup.1 and Z.sup.2 are each independently a selected divalent spacer.

The subject matter of this invention relates to hydrogel compositions and, more particularly, to hydrogel compositions comprising block copolymers (BCPs) capable of self-assembly into nanoparticles for the delivery and controlled release of therapeutic cargos.

A temozolomide compound according to formula (I)

##STR00001##

is described, wherein R.sup.1, L.sup.1, and X are defined herein. The temozolomide compound can be used to prepare polymers comprising temozolomide. Additionally, the polymers comprising temozolomide can be particularly useful in the treatment of certain diseases.

The present invention provides a compound of the formula (I): ##STR00001##
wherein, A is R.sup.6(R.sup.7).sub.s, N, O, S, or NR.sup.5; R.sup.6 is an s-valent organic group; R.sup.7 is each independently, O, S, NR.sup.5 or OP(O)OR.sup.4; R.sup.2 and R.sup.3 are each independently a hydrogen atom or a hydrocarbon group; R.sup.4 is each independently, a hydrocarbon group; R.sup.5 is each independently, a hydrogen atom or a hydrocarbon group; and s is an integer of 1-10.

Di(amido(alkyl)phenol) compounds and upgraded molecular weight polymers made from such compounds have particular utility in coating compositions, especially for use on food and beverage contact substrates that are formed into or will be formed into containers or container components.

Di(amido(alkyl)phenol) compounds and upgraded molecular weight polymers made from such compounds have particular utility in coating compositions, especially for use on food and beverage contact substrates that are formed into or will be formed into containers or container components.