The present invention relates to electrospun fibers comprising i) a hydrophilic polymer that is soluble in a first solvent, ii) a bioadhesive substance that is slightly soluble in said first solvent, iii) optionally, a drug substance.

Disclosed are methods of forming grafts (e.g., autologous vascular grafts, biliary conduits, ureter conduits, etc.) for implantation into subjects in need thereof. The methods employ an electrospun scaffold formed from nanofibers that comprise a blend of a biodegradable synthetic polymer and a biopolymer. Extracellular matrix-producing cells (e.g., fibroblasts) can then be cultured on the electrospun scaffold in a bioreactor to form a cellular, tubular structure. The tubular structure can then be decellularized, and endothelial cells (e.g., endothelial cells obtained from the subject) can be cultured on the resulting decellularized scaffold to form a graft (e.g., autologous vascular grafts) for implantation into a subject. Because decellularized scaffolds can be prepared in advance, the methods described herein can be used to prepare autologous grafts for implantation in a subject in a relatively short, clinically relevant timeframe (e.g., from one week to one month).

Disclosed herein is a method for producing isotropized ready-to-use polymer pellets or granules that contain completely or substantially relaxed matrix molecules and entangled organic nanofibrils with long aspect ratios that will provide superior properties for the products without high cost. These pellets are cost-effectively produced using industrial-scale fiber spinning or melt-blowing/spun-bond equipment followed by an isotropizing pelletizer. These pellets enable one to mass-produce the micro-fibrillar or nanofibrillar composites with superior mechanical properties, because they are readily usable (ready-to-use) for industry-scale mass production systems with a very high throughput over 1000 kg/hr. The organic nanofibrils are well dispersed and entangled in the polymer matrix and have a long aspect ratio ranging hundreds to thousands, to tens of thousands. The nanofibrils are entangled with each other to have proper rheological properties for film or foam processing, and to have good mechanical properties of the final products.

A present invention is directed to a laminated filtration media comprising a nanofiber coating applied onto a synthetic substrate. Generally, the laminated filtration media can be produced by applying the nanofiber layer onto the synthetic substrate via an electrospinning process and then thermo-mechanically bonding the nanofiber layer onto the synthetic substrate via a thermal bonding process. The laminated filtration media exhibits superior durability and can be used in a wide array of air filtration applications.

The present invention relates generally to compositions for use in biological and chemical separations, as well as other applications. More specifically, the present invention relates to hybrid felts fabricated from electrospun nanofibers with high permeance and high capacity. Such hybrid felts utilize derivatized cellulose, and at least one non-cellulose-based polymer that may be removed from the felt by subjecting it to moderately elevated temperatures and/or solvents capable of dissolving the non-cellulose-based polymer to leave behind a porous nanofiber felt having more uniform pore sizes and other enhanced properties when compared to single component nanofiber felts.

The present invention relates generally to compositions for use in biological and chemical separations, as well as other applications. More specifically, the present invention relates to hybrid felts fabricated from electrospun nanofibers with high permeance and high capacity. Such hybrid felts utilize derivatized cellulose, and at least one non-cellulose-based polymer that may be removed from the felt by subjecting it to moderately elevated temperatures and/or solvents capable of dissolving the non-cellulose-based polymer to leave behind a porous nanofiber felt having more uniform pore sizes and other enhanced properties when compared to single component nanofiber felts.

A collagen containing-plastic masterbatch of which the composition includes a thermoplastic polymer and a collagen is provided, wherein the collagen is uniformly distributed in the thermoplastic polymer, and wherein in the collagen containing-plastic masterbatch, the collagen content is about 1-50 wt %. A collagen containing-plastic fiber formed by at least one kind of plastic masterbatch through melt spinning is further provided, wherein the at least one kind of plastic masterbatch includes the above-mentioned collagen containing-plastic masterbatch.

Composites based on a polymer and a mixture of proteins derived from a MaSp (major ampullate spidroin) protein are provides. Further, methods for preparation of same, and method of use of the composites are provided.

Composites based on a polymer and a mixture of proteins derived from a MaSp (major ampullate spidroin) protein are provides. Further, methods for preparation of same, and method of use of the composites are provided.

Composites based on a polymer and a mixture of proteins derived from a MaSp (major ampullate spidroin) protein are provides. Further, methods for preparation of same, and method of use of the composites are provided.