A wound dressing, including fibers containing silver ions. The fibers are manufactured by dissolving silver nitrate into a polymer solution in the substantial absence of light, and then extruding the obtained solution into fibers by wet spinning process. The silver content of the wound dressing is between 0.01-10% by weight, and preferably 0.1-7% by weight.

The present application provides a manufacturing method and a spinneret assembly that includes a nozzle body, an outer spinning solution channel formed inside the nozzle body, and at least one inner spinning solution channel formed inside the nozzle body. A nozzle outlet formed at an end of the nozzle body is immersed in a solidification liquid. The outer spinning solution channel includes an outer liquid outlet, and the at least one inner spinning solution channel includes an inner liquid outlet. The outer liquid outlet and the inner liquid outlet communicate with the nozzle outlet and are confluent at the nozzle outlet. A diameter of the inner liquid outlet is smaller than a diameter of the outer liquid outlet. An outer-layer dope spinned from the outer liquid outlet covers an inner-layer dope spinned from the inner liquid outlet so as to generate a solid filamentary fiber with multi-layer materials.

The present application discloses a method to produce fibers with different segments along the major axis. The different segments can be constituted of the same materials that entrap different objects (molecules, particles) or can be made of different materials. The different segments are made thanks to a junction and by alternating the dispensing of such materials using different inlet channels. This method allows the production of fibers that can be used as processed or after being further manipulated by other processes, as single devices or as building blocks to construct devices that are more complex. Fibers with different segments along the axis can be exploited for a wide range of applications as medical devices and/or as drug delivery system and/or as matrices to be used for acellular tissue regeneration and cellular tissue engineering/regenerative medicine strategies and/or as supports for imaging in high throughput screening.

The present application discloses a method to produce fibers with different segments along the major axis. The different segments can be constituted of the same materials that entrap different objects (molecules, particles) or can be made of different materials. The different segments are made thanks to a junction and by alternating the dispensing of such materials using different inlet channels. This method allows the production of fibers that can be used as processed or after being further manipulated by other processes, as single devices or as building blocks to construct devices that are more complex. Fibers with different segments along the axis can be exploited for a wide range of applications as medical devices and/or as drug delivery system and/or as matrices to be used for acellular tissue regeneration and cellular tissue engineering/regenerative medicine strategies and/or as supports for imaging in high throughput screening.

The present invention provides a natural polymeric nanofiber, which is made by a natural polymeric solution under an applied field control spinning process, wherein the natural polymeric solution comprises: a natural polymeric material, an inorganic salt and/or an enzyme; the present invention further provides a method for preparing the natural polymeric nanofibers. The nature polymeric nanofibers of the present invention have a smaller fiber diameter, and have higher safety and practicability.

The present disclosure provides an antimicrobial alginate fiber, a method for manufacturing an antimicrobial alginate fiber dressing thereof, and an application thereof. When the cationic polymer polyhexamethylene guanide salt is mixed with the anionic polymer alginate, the antimicrobial activity of the guanide salt is quickly passivated. The present disclosure achieves a lower content of polyhexamethylene guanide salt in an alginate dressing with good long-term antimicrobial activities. The polyhexamethylene guanide salt has a low dissolution rate, and significantly reduces a potential risk of carcinogenicity, mutagenicity and reproductive toxicity.

The present disclosure provides an antimicrobial alginate fiber, a method for manufacturing an antimicrobial alginate fiber dressing thereof, and an application thereof. When the cationic polymer polyhexamethylene guanide salt is mixed with the anionic polymer alginate, the antimicrobial activity of the guanide salt is quickly passivated. The present disclosure achieves a lower content of polyhexamethylene guanide salt in an alginate dressing with good long-term antimicrobial activities. The polyhexamethylene guanide salt has a low dissolution rate, and significantly reduces a potential risk of carcinogenicity, mutagenicity and reproductive toxicity.

The present application provides a manufacturing method and a spinneret assembly that includes a nozzle body, an outer spinning solution channel formed inside the nozzle body, and at least one inner spinning solution channel formed inside the nozzle body. A nozzle outlet formed at an end of the nozzle body is immersed in a solidification liquid. The outer spinning solution channel includes an outer liquid outlet, and the at least one inner spinning solution channel includes an inner liquid outlet. The outer liquid outlet and the inner liquid outlet communicate with the nozzle outlet and are confluent at the nozzle outlet. A diameter of the inner liquid outlet is smaller than a diameter of the outer liquid outlet. An outer-layer dope spinned from the outer liquid outlet covers an inner-layer dope spinned from the inner liquid outlet so as to generate a solid filamentary fiber with multi-layer materials.

Methods of culturing and manufacturing of cells on a large-scale level are disclosed. Particularly, a manufacturing system and device, and methods of using the system and device for culturing and manufacturing cells in hollow fibers made from alginate polymers are provided.

Fibres suitable for use in the production of wound dressings comprise carboxymethyl cellulose and alginate in a total amount of at least 90% by weight of the fibre, the carboxymethyl cellulose and alginate are homogeneously distributed throughout the fibre and are present in amounts such that: (a) the amount of carboxymethyl cellulose present in the fibre is at least 50% by weight of the total weight of the carboxymethyl cellulose and alginate; (b) the alginate has a Guluronate-content of 50-90% by weight, and (c) the value of z given by the expression (1): z=(2x/40)/(2x/40)+(y/23) where x and y are the percentages by weight of calcium and sodium respectively in the fibres is at least 80. The fibres may be produced by spinning a solution comprising dissolved CMC and alginate in appropriate proportions into a coagulation bath containing calcium ions.