The instant invention provides for novel lipid nanoparticle (LNP) formulations, containing cationic lipids, for use as vaccine adjuvants and/or as antigen delivery systems. It is an object of the instant invention to provide LNP formulations that demonstrate enhancements in humoral and/or cellular immunogenicity of vaccine antigens, particularly subunit vaccine antigens, when utilized alone or in combination with immunostimulatory agents (e.g. small molecule or oligonucleotide TLR agonists). The instant invention further identifies physical and chemical properties of the LNP formulations that can be manipulated to enhance antigen efficiency and adjuvant tolerability in vivo.

The instant invention provides for novel lipid nanoparticle (LNP) formulations, containing cationic lipids, for use as vaccine adjuvants and/or as antigen delivery systems. It is an object of the instant invention to provide LNP formulations that demonstrate enhancements in humoral and/or cellular immunogenicity of vaccine antigens, particularly subunit vaccine antigens, when utilized alone or in combination with immunostimulatory agents (e.g. small molecule or oligonucleotide TLR agonists). The instant invention further identifies physical and chemical properties of the LNP formulations that can be manipulated to enhance antigen efficiency and adjuvant tolerability in vivo.

A steam ironing and/or smoothing appliance including an ironing board against which a garment to be ironed can be placed for a steam treatment, the ironing board being mounted with the ability to pivot by a hinge device enabling the ironing board to be immobilized in various tilted positions, the hinge device including a first part which is mobile in rotation in relation to a second part, the first part including at least one notch in which is engaged at least one locking element carried by the second part in order to prevent the hinge device from rotating, wherein the second part is mobile in translation in relation to the first part according to a course and a direction enabling the locking element to engage and disengage in the notch.

A steam ironing and/or smoothing appliance including an ironing board against which a garment to be ironed can be placed for a steam treatment, the ironing board being mounted with the ability to pivot by a hinge device enabling the ironing board to be immobilized in various tilted positions, the hinge device including a first part which is mobile in rotation in relation to a second part, the first part including at least one notch in which is engaged at least one locking element carried by the second part in order to prevent the hinge device from rotating, wherein the second part is mobile in translation in relation to the first part according to a course and a direction enabling the locking element to engage and disengage in the notch.

The present invention relates to a system iron. The system iron of the present invention includes a body including therein a steam generator for generating steam; an ironing plate disposed on the body so as to spray the steam generated by the steam generator to an outside; a height adjustment box, which is retracted into the body and extended outwards from the body so as to adjust a height of the ironing plate; a lock including a first bar, which projects outwards from the height adjustment box so as to limit the movement of the height adjustment box; a lock holder, which is connected to two side surfaces of an end of the lock so as to change the position of the first bar, thereby allowing the height adjustment box to be moved; and a height adjustment lever for moving the lock holder via a wire.

The present invention relates to a system iron. The system iron of the present invention includes a body including therein a steam generator for generating steam; an ironing plate disposed on the body so as to spray the steam generated by the steam generator to an outside; a height adjustment box, which is retracted into the body and extended outwards from the body so as to adjust a height of the ironing plate; a lock including a first bar, which projects outwards from the height adjustment box so as to limit the movement of the height adjustment box; a lock holder, which is connected to two side surfaces of an end of the lock so as to change the position of the first bar, thereby allowing the height adjustment box to be moved; and a height adjustment lever for moving the lock holder via a wire.

An apparatus for steam treatment of laundry including an ironing and/or smoothing tool includes at least one hole for the emission of steam and at least one pole which supports an ironing board including a bearing surface that can be arranged vertically and against which a garment to be smoothed can be arranged so that it can be steam-treated using the tool, wherein the board includes at least two parts put end to end and which together at least partially define the bearing surface, and wherein the two parts of the board are connected to one another by at least one connecting rod.

An apparatus for steam treatment of laundry including an ironing and/or smoothing tool includes at least one hole for the emission of steam and at least one pole which supports an ironing board including a bearing surface that can be arranged vertically and against which a garment to be smoothed can be arranged so that it can be steam-treated using the tool, wherein the board includes at least two parts put end to end and which together at least partially define the bearing surface, and wherein the two parts of the board are connected to one another by at least one connecting rod.

A system iron according to the present invention includes a body including a steam generator for generating steam; an ironing plate rotatably disposed on the body and spraying the steam, which is generated by the steam generator, to an outside thereof, a top being hung on an outer side of the ironing plate; a spreading unit for tensioning the top hung on the outer side of the ironing plate; a front press for holding a front surface of the top, which is hung on the outer side of the ironing plate; and a pair of arm tensioners for tensioning sleeves of the top hung on the outer side of the ironing plate.

A system iron according to the present invention includes a body including a steam generator for generating steam; an ironing plate rotatably disposed on the body and spraying the steam, which is generated by the steam generator, to an outside thereof, a top being hung on an outer side of the ironing plate; a spreading unit for tensioning the top hung on the outer side of the ironing plate; a front press for holding a front surface of the top, which is hung on the outer side of the ironing plate; and a pair of arm tensioners for tensioning sleeves of the top hung on the outer side of the ironing plate.