Systems and methods of fabricating corrugated electrospun fiber assemblies are disclosed herein. The method can include placing an electrospun fiber scaffold on a corrugation rod, wherein the corrugation rod comprises a helical structure; applying a monofilament fiber about the electrospun fiber scaffold and the corrugation rod from a dispenser as the dispenser is translated longitudinally and the corrugation rod is rotated such that the monofilament fiber is wrapped about the electrospun fiber scaffold at a defined threads per inch (TPI) to form a wrapped electrospun fiber assembly; and longitudinally compressing the corrugated electrospun fiber assembly until it has been compressed from a first length to a second length to form the corrugated electrospun fiber assembly. The corrugated electrospun fiber assemblies can be kink-resistant as compared to conventional electrospun fiber scaffolds. The corrugated electrospun fiber assemblies can be used in, for example, biological applications within a subject.

According to an embodiment, an electrospinning apparatus includes an electrospinning head and a storage case. The electrospinning head includes a nozzle capable of ejecting a material liquid and is movable between a first move position and a second move position. In the storage case, a storage hollow capable of accommodating a nozzle is formed, and an opening to the outside of the storage hollow is formed in the storage case. The storage case causes the nozzle of the electrospinning head located at the first move position to be arranged at a position separate from the storage hollow and causes the nozzle of the electrospinning head located at the second move position to be accommodated inside the storage hollow.

According to an embodiment, an electrospinning head includes a nozzle and an uneven surface. The nozzle is made from an electrically conductive material, and a flow path is formed inside the nozzle. On the outer surface of the nozzle, an ejection port capable of ejecting a material liquid supplied to the flow path is formed. The uneven surface is formed in the vicinity of the projection port on the outer surface of the nozzle, and an uneven shape of the uneven surface is formed around the entire circumference of the circumferential direction of the nozzle and is along the extending direction of the flow path.

A device having: an article having a flat surface and a lower surface opposed to the flat surface; a cavity formed in the lower surface forming a complete loop surrounding a central portion of the article; a heating element having the same shape as the complete loop in the cavity and positioned to warm a portion of the flat surface adjacent to the heating element when the heating element is activated; a cooling device positioned to cool a portion of the flat surface in the central portion; and a release layer on the flat surface. A device having: an article having an upper surface; a heating element on the upper surface forming a complete loop surrounding a central portion of the article; and an electrically insulating material on the upper surface within the central portion.

Systems and methods for creating coating a substrate with nanofiber comprise a dual polarity high voltage power supply, a first wire for wire electrospinning held at positive potential by the power supply, a second wire held at negative potential by the power supply and a spooling system for drawing a substrate between the first wire and the second wire. A slider and a solution chamber in fluidic connection with the slider are used to slide along the first wire delivering solution to the wire.

Device for the production of nanofibrous and/or microfibrous layers having an increased thickness uniformity by spinning a liquid material (3), said device comprising: a collecting electrode (6), a spinning nozzle (1) for dispensing the liquid material (3) to be spun, an assembly for guiding the collecting electrode (6) and/or for guiding a base strip (5) along the collecting electrode (6) or adjacent to it, such that—in the area faced by the outlet orifice (10) of the spinning nozzle (1)—the collecting electrode (6) and/or the base strip (5) move(s) in the direction (MD) spaced from the outlet orifice (10) of the spinning nozzle (1), a power supply for generating a voltage of 10 to 150 kV between the collecting electrode (6) and the spinning nozzle (1), at least one body (2), which moves along the liquid surface to destabilize the locations of the points where fibres (4) are formed on the surface of the liquid material (3) at the outlet orifice (10) of the spinning nozzle (1). The nanofibrous and/or microfibrous layers having an increased thickness uniformity are produced by spinning a liquid material (3) in an electrostatic field, wherein a body (2) is moved along the surface of the spun liquid in order to destabilize positions of locations, where the fibers originate.

A continuous wire drive system for a needleless electrospinning apparatus, the electrospinning apparatus including an electrospinning enclosure and within which a nanoscale or submicron scale polymer fiber web is formed onto a substrate from a liquid polymer layer coated onto a plurality of continuous electrode wires passing through the electrospinning enclosure. The continuous wire drive system includes a master wire drive drum and a slave wire drive drum, each of the master wire drive drum and slave wire drive drum including a plurality of wire guides, each of the wire guides including a channel or groove for receiving one of the plurality of continuous electrode wires. The continuous wire drive system is external to the electrospinning apparatus, and the continuous wire drive system drives the plurality of continuous electrode wires through the electrospinning enclosure.

A three-dimensional electrospun biomedical patch includes a first polymeric scaffold having a first structure of deposited electrospun fibers extending in a plurality of directions in three dimensions to facilitate cellular migration for a first period of time upon application of the biomedical patch to a tissue, wherein the first period of time is less than twelve months, and a second polymeric scaffold having a second structure of deposited electrospun fibers. The second structure of deposited electrospun fibers includes the plurality of deposited electrospun fibers configured to provide structural reinforcement for a second period of time upon application of the three-dimensional electrospun biomedical patch to the tissue wherein the second period of time is less than twelve months. The three-dimensional electrospun biomedical patch is sufficiently pliable and resistant to tearing to enable movement of the three-dimensional electrospun biomedical patch with the tissue.

In one embodiment, a fiber manufacturing apparatus has a discharge head which discharges a raw material liquid in which a polymer is dissolved in a solvent toward a collector, and a power source which generates a potential difference between the discharge head and the collector. The fiber manufacturing apparatus further has a recovery device, a cleaning device, and a moving device. The recovery device recovers the raw material liquid to be discharged by the discharge head. The cleaning device cleans the discharge head. The moving device moves the discharge head to any position out of a spinning position where the discharge head and the collector are opposite to each other, a recovery position where the discharge head and the recovery device are opposite to each other, and a cleaning position where the discharge head and the cleaning device are opposite to each other.

The present invention provides a preparation method preparation method for three-layer artificial blood vessel and application thereof. The three-layer artificial blood vessel comprise three layers, electrospinning inner layer, dense middle layer and electrospinning outer layer, the three-layer structure is closely combined and difficult to separate. The inner layer with a cytoskeleton-like structure can promote the formation of intima; the dense middle layer can effectively prevent the leakage of biomacromolecules and increase the puncture resistance of the whole artificial blood vessel; and the outer layer can promote the growth of tissue cells and better integrate with tissue. The three-layer artificial blood vessel provided by the invention has excellent blood compatibility, good flexibility, good puncture resistance and interlayer peeling resistance. The preparation method is convenient and is suitable for industrial scale production.