The present disclosure relates to extracellular vesicles (EVs) that are capable of targeting a cell in the CNS of a subject. Also provided herein are methods for producing the EVs and methods for using the EVs to treat and/or prevent diseases or disorders of the CNS (e.g., neurological disorders).

A high frequency chest wall oscillation therapy system includes an air pulse generator. The air pulse generator includes control circuitry and a fluid chamber carrying a fluid. A motor is configured to generate compression and expansion of the fluid in the fluid chamber to generate pressurized fluid. A pressure sensor detects a pressure of the pressurized fluid in the fluid chamber. A garment includes at least one fluid bladder defining a pressurizable chamber adapted to receive the pressurized fluid from the fluid chamber to provide a force of high frequency pressure oscillation to a patient's chest wall.

Described herein are methods, devices and systems for respiratory therapy delivered by a therapy vest. A therapy vest is provided in which an independent body fitting function is provided by use of a body fit layer or compartment(s). The body fit layer or compartment(s) may be controlled independently from the therapy layer or compartment(s), such that the fit of the therapy vest is placed on more equal footing with the therapy delivering components of the therapy vest. Other examples are disclosed and claimed.

The non-invasive pulsatile circulatory support device intended to promote circulation of a blood volume in at least a part (Z) of a subject's body, the device including a flexible structure, arranged so as to be applied on at least the part of the subject's body, including a series of paired adjacent pouches extending along one another; and means for generating a physiologically synchronised pulsation fluidically connected to the flexible structure in a leak-tight manner and arranged so as to create pulsation waves in the series of pouches between the inner and outer layers, one of the paired adjacent pouches at least partially covering the other of the paired adjacent pouches (scaled structure).

A percussion apparatus for sputum clearance includes a percussion unit, a drive unit, and a control unit, the percussion unit includes a percussion member and an angle detector, the angle detector is configured to detect an included angle between the reference plane and a horizontal plane, the control unit is electrically connected with the drive unit, and when the included angle conforms to a preset angle, the control unit controls the drive unit to drive the percussion unit to periodically percuss, which greatly saves the manpower and increase the efficiency of sputum clearance.

A back clapping machine with chest percussion function includes a casing, a movement mechanism, a clap mechanism, and a buffer unit. The casing includes an outer cover, a rear cover, and a housing space therein, in which the movement mechanism is disposed. The clap mechanism is in the housing space and connected with the front lateral side of the movement mechanism. The buffer unit is in the housing space and arranged to elastically abut against the outer cover and the rear cover therebetween. Thus, the present invention automatically carries out back clapping operation and detects the distance for back clapping, also provides a shock buffering effect, thus achieving a back clapping chest percussion operation through a hand alike structure and preventing pressure ulcer.

The present invention is a method for improving hemodynamics and clinical outcome of patients suffering cardiac arrest and other low-flow states by combination of circumferential constriction and anteroposterior compression decompression of the chest cardiopulmonary resuscitation. Anteroposterior compression decompression may be provided by a piston mechanism attached to a gantry above the patient. Circumferential constriction may be achieved by inflation of pneumatic bladders or shortening of a band. The on-off sequence and relative force of circumferential constriction and anteroposterior compression decompression may be adjusted so as to improve efficacy.

Formulations of human amniotic fluid and methods of use thereof for treatment of lung disorders, and/or injuries have been developed. The formulations are suitable for topical delivery to the lung for treatment of lung disorders including chronic obstructive pulmonary disorders (COPD), asthma, emphysema, bronchiectasis, chronic bronchitis, interstitial lung disease, alpha-1 antitrypsin emphysema, as well as for treatment of acute lung injuries. Methods including administering specifically formulated, diluted sterile de-cellularized human amniotic fluids topically to the lungs, preferably as aerosol droplets, are described. In particular, the methods involving administration of the amniotic fluid formulation in the form of aerosol droplets with size between about 1.5 μm to about 5 μm, preferably from about 2.5 μm to about 3.5 μm, inclusive, using apparatus such as high-efficiency vibrating mesh nebulizers, are described. Formulations described can treat, or prevent one or more symptoms of a chronic lung disorder.

A patient care system for treating a patient is provided. The patient care system includes a patient transport apparatus, a chest compression system configured to provide automatic chest compressions to a patient, and a retainer for securing the chest compression system to the patient transport apparatus. The patient transport apparatus includes a base, an intermediate frame arranged for movement relative to the base, and a patient support deck which defines a patient support surface. The chest compression system includes a driver having a driver body movably supporting a plunger, and a driver frame to support the driver adjacent to the chest of the patient. The retainer includes a collar releasably engageable with the chest compression system, and a brace including a retainer mount and a tether. The brace is arranged to secure the chest compression system to the intermediate frame of the patient transport apparatus.

A patient care system for treating a patient is provided. The patient care system includes a patient transport apparatus, a chest compression system configured to provide automatic chest compressions to a patient, and a retainer for securing the chest compression system to the patient transport apparatus. The patient transport apparatus includes a base, an intermediate frame arranged for movement relative to the base, and a patient support deck which defines a patient support surface. The chest compression system includes a driver having a driver body movably supporting a plunger, and a driver frame to support the driver adjacent to the chest of the patient. The retainer includes a collar releasably engageable with the chest compression system, and a brace including a retainer mount and a retainer frame. The brace is arranged to brace the chest compression system rigidly against the intermediate frame of the patient transport apparatus.