Described are methods of treating a mammalian subject who is intending to undergo exposure to an inoculant comprising a virus, polynucleotide(s) encoding at least a portion of the virus, and/or epitope(s) of the virus, the method including administering at least one bioelectric signal to the subject before exposure to the inoculant in such a manner as to increase the subject's T cell count and/or T helper cell count. Also described are methods of treating a mammalian subject undergoing a viral infection, the method comprising: administering bioelectric signals to the subject so as to upregulate expression of SDF-1 in the subject, upregulate expression of PDGF in the subject, upregulate stem cell proliferation in the subject, and upregulate expression of klotho in the subject; reducing inflammation in the subject, and administering bioelectric signals to the subject so as to stimulate regeneration of the subject's lungs and blood vessels.

The present disclosure pertains to a system configured to determine one or more parameters of chest wall oscillation therapy for a subject. The system includes a wearable garment configured to provide percussion to one or more parts of a lung of a subject. The wearable garment includes: percussion excitation elements configured to produce the percussion; and sensors configured to generate output signals conveying information related to a response of the one or more parts of the lung to the percussion. The system includes a control unit configured to determine frequency and energy density information for the sounds made by the one or more parts of the lungs caused by the percussion, the frequency and energy density information determined based on the output signals; and determine the one or more parameters of the chest wall oscillation therapy based on the frequency and energy density information.

A respiration-assistance apparatus or method can include or use a lifting element such as to cyclically push, pull, or lift, toward a superior direction of the subject, at least one subject region during an inhalation portion of a respiration cycle of the subject. A cyclical member can couple the lifting element to a fixed reference. Abdominal or ribcage compression can be provided. A multi-action or other cam can be used, such as together with a reciprocating element. Examples can be configured for use with a wheelchair, a bed, a vacuum or suction affixation element, a wearable garment, etc.

Techniques and devices for extending a piston and/or compression unit, for example connected to a medical device such as a mechanical CPR device, to accommodate different sized patients, are described herein. In some cases, a piston of a mechanical CPR device may include an inner piston at least partially slidable into an external piston sleeve. In one aspect, some aspects, the piston includes sleeves which can move relative to each other to extend the piston. In additional aspects, the compression mechanism may also extend downward toward the patient. In all aspects, the change in length of the piston may be detected and used to modify movement of the piston, for example to more safely perform mechanical CPR.

A system includes a guidance device that provides feedback to a user to compress a patient's chest at a rate of between about 90 and 110 compressions per minute and at a depth of between about 4.5 centimeters to about 6 centimeters. The system includes a pressure regulation system having a pressure-responsive valve that is configured to be coupled to a patient's airway. The pressure-responsive valve is configured to remain closed during successive chest compressions in order to permit removal at least about 200 ml from the lungs in order to lower intracranial pressure to improve survival with favorable neurological function. The pressure-responsive valve is configured to remain closed until the negative pressure within the patient's airway reaches about −7 cm H.sub.2O, at which time the pressure-responsive valve is configured to open to provide respiratory gases to flow to the lungs through the pressure-responsive valve.

Devices and methods for CPR chest compression with active decompression.

Compression garments may include mitts and tightening apparatus to don, or put on, such compression garments. The mitts may be configured to receive a user's hand such that the user can move one or more portions of the garments using the mitts. The tightening apparatus may allow a user to selectively tighten or loosen the garments about the user's body portions. Once donned, the compression garments may apply pressure to one or more regions of the user's body such as, e.g., arm regions, shoulder regions, torso regions, and neck regions.

A system and method for mechanical CPR can include a device for providing compressive force to various locations on a patient, and biological monitoring systems to measure the effectiveness of the various locations of compressive force in pumping blood through the patient. The system can also include providing decompressive force to increase the efficacy of blood flow.

Provided herein are methods of treatment, including methods of treating subjects having or at risk of having or having a viral infection, and specifically a SARS-CoV-2 viral infection. The methods provided include the administration of 4-methylumbelliferone (4-MU), palmitoylethanolamide (PEA), reservatrol, fisetin, H.sub.2, nebulized hyaluronidase or combinations thereof. Also provided herein are a respiratory assistance device, methods of generating a customized respiratory assistance device, methods of treating a coronavirus infection, and methods of inhibiting a coronavirus infectivity, virulence and/or spread.

A device for compressing the chest of a cardiac arrest victim.