A dispenser actuator assembly (100) for actuating a dispenser (10) is disclosed. The dispenser (10) is in the form of a glass ampoule assembly (10) having a rupturable glass ampoule (12) containing a flowable material (M). The glass ampoule (12) is contained within an outer container (14) wherein the outer container (14) has a first open end (22) and a second closed end (24). The glass ampoule assembly (10) has an applicator (16) positioned in the first open end (22). The dispenser actuator assembly (100) has a base member (102) configured to mount on the outer container (14). The dispenser actuator assembly (100) also has an actuator assembly (104) operably connected to the base member (102) wherein the actuator assembly (104) has a first actuator arm (132a) and a second actuator arm (132b) each pivotally connected to the base member (102). The first actuator arm (132a) and the second actuator arm (132b) extend from the base member (102) in generally opposed relation defining a first position, or neutral position. The first actuator arm (132a) has a first protrusion (150a) depending therefrom and the second actuator arm (132b) has a second protrusion (150b) depending therefrom. The first actuator arm (132a) and the second actuator arm (132b) are pivotable from the first position towards one another to a second position, or actuating position, that is configured such that the first protrusion (150a) engages the outer container (14) and the second protrusion (150b) engages the outer container (14) to crush the glass ampoule (12) wherein the flowable material (M) is configured to be dispensed from the glass ampoule assembly (10).

A system including a vial and methods of its use to provide a lyophilized cake removable from the vial without cracking or breaking.

A delivery device includes a base body having an outlet opening and a chamber for receiving a flowable substance to be administered. The base body, having first and second film portions attached to each other by a connection with a plurality of regions, being configured to discharge the substance through the outlet opening by compressing the chamber. The delivery device further includes a pouring adapter tightly connected to the outlet opening. The plurality of regions of the connection include a more resilient region and a less resilient region that are arranged between the chamber and the outlet opening. When the chamber is compressed to discharge the substance through the outlet opening, the less resilient region is configured to come undone and the more resilient region is configured to remain connected so that the substance can be discharged solely through the outlet opening and the pouring adapter by compressing the chamber.

A drug-filled synthetic resin ampule includes an ampule body and a drug 8 filled in the ampule body. The ampule body includes a tip-side sealing portion, a hollow portion, and an annular breakable portion provided between the tip-side sealing portion and the hollow portion. The tip-side sealing portion includes a flat plate portion for grasping formed at an upper portion thereof, and an internal ceiling portion exposed to the interior of the hollow portion. The breakable portion includes an annular smallest diameter portion, and the smallest diameter portion is located near an annular circumferential edge portion of the internal ceiling portion and is located above the annular circumferential edge portion of the internal ceiling portion.

The present invention is a resin container in which an inner wall surface of a container body includes a cyclic olefin copolymer, and a diameter upstream of an outlet of the container body ranges from 0.5 mm to 8.0 mm.

In one aspect of the subject invention, a labeling shell is provided for a drug vial having a glass reservoir and an opening sealed by an elastomeric stopper, the labeling shell including: a polymeric tubular body formed to accommodate the reservoir of the drug vial, the tubular body having a first open end defining a first opening smaller than a diameter of the reservoir of the drug vial so as to prevent passage therethrough of the reservoir, wherein the elastomeric stopper is exposed through the first end with the reservoir being accommodated in the tubular body; and, a polymeric cap removably mountable to the tubular body to selectively cover the elastomeric stopper of the drug vial with the reservoir being accommodated in the tubular body. Advantageously, the subject invention provides a labeling surface for a drug vial, while also providing restricted access to the drug vial to limit tampering therewith.

At least one closed container includes a glass container having a total height, being characterized by a center axis and including a shoulder region; and a press-fit cap closing the glass container and including a cylindrical body having an upper end and a lower end. P is any given point at the lower end of the press-fit cap that is located above the shoulder region and that lies on a straight line running parallel to the center axis and hitting an outer surface of the shoulder region at a point Q. Among these points P at the lower end of the press-fit cap point P′ is the one that has a smallest distance to its corresponding point Q′ and a distance between points P′ and Q′ on the straight line is in a range from 0.17 to 8.4 mm.

A polymer vial with a tubular body having a geometric shape including (i) a neck having an opening orifice, and (ii) a closed base formed by flattening and sealing a bottom edge of the tubular body. The vial will also include a snap off cap integrally formed on the neck and a liquid content contained in the tubular body. A plurality of dosage lines are printed on the tubular body, the dosage lines having a non-uniform spacing corresponding to the variable volume per unit length of the vial geometric shape. Each line corresponds to a dosage volume of the liquid content when the opening orifice is oriented in the vertically upward position.

The disclosure is directed to pharmaceutical compositions comprising esketamine or a pharmaceutically acceptable salt thereof and an oxidative degradant. In certain aspects, the oxidative degradant is 6-(2-chlorophenyl)-6-oxohexanoic acid or a pharmaceutically acceptable salt thereof. Methods for limiting the formation of oxidative degradants in a pharmaceutical composition comprising esketamine or a pharmaceutically acceptable salt thereof are also disclosed.

A transport or packaging container accommodating a plurality of supporting structures for closures, for transporting or packaging closures for closing cartridges for use in pharmaceutical, medical or cosmetic applications, in which the transport or packaging container is box-shaped and includes a bottom, which is closed or sealed by a seal, upstanding lower side-walls extending essentially perpendicularly from the bottom, a circumferential supporting step extending horizontally from the upstanding lower side-walls, upper side-walls extending upward from said circumferential supporting step, and a circumferential flange formed at upper ends of the upper side-walls; and the plurality of supporting structures for closures is accommodated inside the transport or packaging container.