Stable lyophilized therapeutic protein compositions and their methods of manufacture are provided. Specifically, the use of water as a solid cake plasticizer and protein stabilizer is described. Also, the inclusion of a multicomponent stabilizer comprising a larger molecular entity and a smaller molecular entity is described. Also, the inclusion of post-drying annealing under certain conditions improves protein stability. Proteins are predicted to remain stable over 24 months at 25° C.

A disposable container for containing a patient-customized medicinal fluid as a flowable material, which is adapted to dispense and seal the flowable material, the disposable container including: a plurality of container portions adapted to form spaces containing the flowable material; a bonding portion extended from tops of the container portions in such a manner as to come into contact with a surface of a film protecting the flowable material from the outside; and discharge portions extended from undersides of the container portions in such a manner as to be separable from the containing portions to discharge the flowable material to the outside, wherein the bonding portion connects the container portions with each other.

At least one system for storage of pharmaceutical compositions includes: a container including a neck and a crown that includes an upper crown surface; a stopper including a flange and a plug, the flange including a lower flange surface and a flange height; and a holding element configured to exert a force on the crown and the flange to form a horizontal contact area between the upper crown surface and the lower flange surface. The horizontal contact area has a size of 30 mm.sup.2 to 300 mm.sup.2 and the flange height is compressed at least partially in the horizontal contact area by 10% to 40%.

A pill bottle top includes a top and a base engaged with the top and having first ratchet teeth. An indicator slide has a finger pad formed with an inwardly protruding indicator nose and leaf spring arms coupled to the finger pad and disposed intermediate the top and base. The leaf spring arms are formed with second ratchet teeth configured to engage first ratchet teeth on the base. The finger pad can be pressed against the leaf spring arms to disengage the second ratchet teeth from the first ratchet teeth and allow the indicator slide to slide relative to the top with the indicator nose higher than and alignable with time indicia on the top. The finger pad can be released to allow the second ratchet teeth to engage first ratchet teeth under material bias of the leaf spring arms and prevent the indicator slide from sliding.

A smart medication container cap for medication management and related devices, systems and methods for medication management are provided. The smart cap ensures ensuring accuracy in dispensing, prompts the user promoting compliance, collects information about the medication, transmits the information to a central server or LAN, determining container contents, locations, and surroundings, remotely manages the same, transmits alerts to the user, and communicates with a computer system for the same.

A locking top for blocking a stopper in the neck of a vessel comprises an outer body and a cage that is configured to fit into and lock axially in the outer body. The cage comprises an upper ring, a plurality n of branches connected to the upper ring, n/2 median bridges and n/2 lower bridges arranged in alternation on the periphery of the cage, each connecting together two adjacent branches. When the top is in an intermediate holding position in which the stopper is partially pushed into the neck, the lower bridges surround, at least in part, a collar of the neck; the median bridges located, in an axial direction, between the upper ring and the lower bridges are designed to form an open space between them and the collar.

Assembly with connectable and disconnectable elements comprises a flexible bag containing liquid solution with a first valve connector, at least one vial with active substance and provided with a hermetic closing cap, a coupling and piercing device couplable to the cap of the vial and an adapter between the first connector and the coupling and piercing device. The adapter has a hollow external body with a first end fixable by screwing to the first connector, an axially bored, coaxial internal stem, the screwing causes the opening of the first connector and a second end including a second valve connector fixable to the coupling and piercing device and is screwable in the external body so that internal stem causes the opening of the second valve connector.

Provided is a tissue retrieval bag. The bag is defined by a region of the bag defining an opening; an exterior surface of the bag depending from the opening; and a channel formed into the exterior surface of the bag, wherein the channel provides access to the interior of the bag through the exterior surface. Also provided is a tissue retrieval defined by a region of the bag defining an opening; an exterior surface of the bag depending from the opening; and at least one porthole on the exterior of the bag, wherein at least one tube extends from the at least one porthole.

The present invention relates to a container, which accommodates a drug and is sealed, includes a container stopper part including at least one filling groove formed in order to inject a drug, and a container body including an opening into which the container stopper part is inserted and which is sealed, wherein the filling groove is formed in an outer wall surface of the container stopper part in a longitudinal direction in which the container stopper part is inserted thereinto and forms a passage which is formed between the outer wall surface of the container stopper part and an inner wall surface of the container body and through which the drug is injectable.

This provides pharmaceutical compositions that comprise (i) an anti-LAG-3 antibody or antigen binding fragment thereof or (ii) an anti-LAG-3 antibody or antigen binding fragment thereof and an anti-PD-1 antibody, anti-PD-L1 antibody, or antigen binding fragment thereof. Also provided are pharmaceutical compositions that comprise a buffering agent, stabilizing or bulking agent, and a surfactant. The disclosure also provides a vial, syringe, intravenous bag, or kit that comprises the compositions, and methods for using the compositions.