A device and method for fluidly connecting a drug container with a solution container in a closed state, and for combining contents of the drug container and the solution container in an activated state. The device has a connector body with a first coupling and first fluid passage that connect with the drug container. The connector body also has a second coupling and second fluid passage that connect with the solution container. A control valve has a movable valve body that defines a third fluid passage. The valve body is positionable relative to the connector body in a first position that blocks fluid communication between the first fluid passage and second fluid passage. The valve body is also positionable in a second position that permits fluid communication between the first fluid passage and second fluid passage.

In one general aspect, the present disclosure provides a drainage system. The drainage system may include a container having an interior and a mouth, the mouth having an outer surface and an opening. A frangible seal may cover the opening. A cap may be secured to the mouth, and the cap may be in fluid communication with a drainage line. The cap may have an inner surface for engaging with the outer surface of the mouth. The drainage system may further include a retention ring with a collar having an inner surface configured to engage an outer surface of the cap, where the retention ring includes a bead for at least partially concentrating a restriction force provided by the retention ring on an adjacent area of the outer surface of the cap.

Disclosed is a covering/lid assembly having a first compartment, a second compartment, or both. Each compartment will comprise a top side and a bottom side, the bottom side of the compartment comprising a frangible material. The first or second compartment may comprise a first material or a second material. The first or second material may comprise a flocculated red blood cell coagulant, or a red blood cell flocculent. The material within a compartment may be selectively released upon compressing a dimple and/or button located directly above the first and/or second compartment. A collection and/or biological waste management and disposal system is presented, comprising a lid/covering assembly as described and a collection container. The lid may include a perimeter having a threaded and/or snap-on assembly suitable for securely attaching the lid to a collection canister. The collection canister may comprise a red blood cell flocculent coating.

An evacuated bottle system including a bottle defining a hollow interior, the bottle having a neck with a rim defining an opening; a cap assembly supported on the bottle, the cap assembly including a funnel having a first portion and a second portion, the first portion being insertable within the interior of the bottle and the second portion engaging a portion of the bottle to support the funnel above the rim, the funnel defining a bore that fluidly communicates with the hollow interior of the bottle; a self-sealing membrane that covers the bore formed by the funnel to selectively seal the hollow interior of the bottle; a cap attachable to the bottle, the cap including a cover portion that extends at least partially over the self-sealing membrane to restrain movement thereof, the cover portion being axially spaced from the self-sealing membrane to define a gap that permits axial movement of the self-sealing membrane to selectively open the bottle to fluid communication outside of the bottle.

A specimen transfer device adapted to receive a blood sample is disclosed. The specimen transfer device includes a housing and an actuation member. A deformable material is disposed within the housing and is deformable from an initial position in which the material is adapted to hold the sample to a deformed position in which at least a portion of the sample is released from the material. A viscoelastic member is disposed within the housing between the material and the housing and between the material and the actuation member. The viscoelastic member is engaged with the actuation member and the material such that movement of the actuation member from a first position to a second position deforms the material from the initial position to the deformed position.

An apparatus and methods for embolization of a patient includes vials for containing radiomicrospheres including inclined and domed base are described. Apparatus for delivering the microspheres from the vials to a patient for radioembolization are also described.

In certain embodiments, a vial adaptor for removing liquid contents from a vial comprises a piercing member and a bag. The bag can be contained within the piercing member such that the bag is introduced to the vial when the vial adaptor is coupled with the vial. In some embodiments, the bag expands within the vial as liquid is removed from the vial via the adaptor, thereby regulating pressure within the vial. In other embodiments, a vial comprises a bag for regulating pressure within the vial as liquid is removed therefrom. In some embodiments, a vial adaptor is coupled with the vial in order to remove the liquid. In some embodiments, as the liquid is removed from the vial via the adaptor, the bag expands within the vial, and in other embodiments, the bag contracts within the vial.

A safety vial system has a vial adapter subsystem irreversibly mountable to the top of a vial containing a hazardous medicament and a vial base subsystem sealingly engaging a lower portion of the vial adapter subsystem and telescopically movable therein from a first position providing a path for gas sterilization around the vial to a second position wherein the path is closed to form a sterilized expandable, neutral pressure bellows chamber around and below the vial. The device has a removable top cap, a pierceable barrier film, a normally closed needleless valve in fluid communication with a dual lumen spike initially disposed above the film and a frangible product integrity ring holding the activation housing in place for sealed telescopic movement on a main body that surrounds the vial. The user pulls the product integrity ring and removes it, and then pushes the activation housing axially downward until it clicks to lock the device in the activated position wherein both lumens of the spike are in communication with the inside of the vial. The user removes the top cap on the activation housing assembly, and then uses a needleless syringe with an adapter thereon to add diluent and mixes if needed and withdraw drug from the vial via the valve.

The invention relates to a method fr producing a liquid dosage form of the drug Edaravone for parenteral use which is stable in storage and transportation and convenient for use, which involves: preparing a solution comprising Edaravone or pharmaceutically acceptable salts thereof as the active ingredient, and excipients (an acidic component, an alkaline component, an antioxidant, an osmolar agent and/or a stabilizer); packaging said dosage form in a pre-sterilized glass bottle having a cap at least partially coated with an anti-adhesive coating; sealing the bottle with said cap at least partially coated with an anti-adhesive coating, and sterilizing the bottle containing a solution comprising Edaravone or pharmaceutically acceptable salts thereof as the active ingredient, and excipients. The invention further relates to a method for packaging a liquid dosage form of the drug Edaravone for parenteral use which is stable in storage and transportation and convenient for use, which involves: sterilizing a glass bottle having a cap; pouring a solution comprising Edaravone or pharmaceutically acceptable salts thereof as the active ingredient, and excipients (an acidic component, an alkaline component, an antioxidant, an osmolar agent and/or a stabilizer) into said sterilized glass bottle; closing (sealing) the bottle containing the solution using said cap, which is at least partially coated with an anti-adhesive coating; and sterilizing the sealed bottle containing the liquid dosage form. The invention further relates to a bottle filled with a liquid dosage form of a drug for parenteral use comprising Edaravone or pharmaceutically acceptable salts thereof as the active ingredient, and excipients (an acidic component, an alkaline component, an antioxidant, an osmolar agent and/or a stabilizer), said bottle being made of glass and being closed with a cap which is made of a material based on flexible polymers and which is at least partially coated with an anti-adhesive coating.

Disclosed are polymer vials (110, 210) and injection stretch blow molding methods for making the same. A polymer vial has a base (112) having a base surface area and a sidewall (114) extending up from the base. The base and sidewall define an interior (116) configured to house product, the sidewall narrowing at an upper section of the vial to form a neck leading to an opening that provides access to the interior. The vial is optionally round and symmetrical about a central axis, a lower portion of the sidewall including a first surface that is outwardly curved along a first radius having an imaginary center positioned within the vial. The base is positioned below the first surface and is substantially flat such that at least 80% of the base surface area has a standing base surface occupying a single plane.