A particulate plug for removing a preservative from a solution, suspension, or emulsion comprising a drug is presented. The plug comprises microparticles of a homopolymer comprising a hydrophilic repeating unit or of a copolymer comprising at least one hydrophilic repeating unit and at least one hydrophobic repeating unit. The microparticles are irregular-shaped rigid aggregates and are sized and packed to yield a hydraulic permeability greater than 0.01 Da. The homopolymers have absorbed portions of a preservative to be removed and/or a drug for delivery in solution, as can the copolymer.

An apparatus, method, and article of manufacture for transferring fluid contained in a syringe. The apparatus includes an airlock component having a cylindrical body with a first end, a second end, and a hollow tube disposed between the first end and the second end. An annular opening is located at the first end of the cylindrical body. The hollow tube includes a gas inlet aperture and a gas outlet aperture. The hollow tube also includes an inwardly-facing airtight material coupled to the interior surface of the hollow tube, and a septum coupled to the second end of the cylindrical body. The method includes transferring fluid from one container to a second container using the apparatus. The article of manufacture includes the apparatus, a syringe, and a needle.

A break-open single-dose package includes a panel defining a frangible region, one or more sheets coupled to the panel and defining a pocket therebetween for storing a spreadable consumable, and an applicator. The frangible region is adapted to form an opening through which the spreadable consumable can exit in response to folding of the panel. The applicator includes a backing and a vessel extending from the backing. The vessel defines a channel for receiving any spreadable consumable that exits the pocket. The applicator is positioned adjacent to the frangible region for permitting a user to spread on a surface any spreadable consumable that exits the pocket using the applicator without requiring the user's hand(s) to contact the spreadable consumable. The backing is configured to move with the panel and separate from the vessel in response to folding of the panel. Other example packages and/or applicators are also disclosed.

A system for purifying incoming fluid is provided that is modular and includes a heat exchanger module, an evaporator-condenser module and a compressor. The system is configured to facilitate passive drainage of the purified fluid for collection. The system components are arranged in a stacked configuration to facilitate gravitational flow of the purified fluid such that the purified fluid drains passively for collection. A system for preparation of ready-to-use treatment fluid is also provided including the modular fluid purification system, a preparation station and a coupling device. The components are configured to be retained in a portable carrier that is manually operable for improved access to and mobility of the components. A coupling device for use in connecting flow channels of a plurality of components and for use in preparing ready-to-use dialysate is also provided, A further system for preparation of a receptacle and a ready-to-use treatment fluid in the receptacle is also provided.

A syringe adapter is provided. The adapter includes a housing having a first end and a second end positioned opposite the first end. The first end of the housing has a connector configured to be secured to a syringe barrel. The adapter also includes a cannula positioned within the housing and a seal arrangement including a membrane or septum positioned within the housing and movable within the housing, the seal arrangement comprising a membrane. The assembly can also include a protective cap having a first open end and a second closed end. The protective cap can be connected to the housing via a snap fit and can be configured to receive the second end of the housing.

Provided is a medication dispenser configured to discharge a liquid state medication stored therein by a pumping operation in a predetermined amount in a drop state and prevent a noise occurrence during medication discharge, and having a bacteria infiltration prevention function, wherein a flow path member and a second check valve are mounted in a liner, the second check valve is composed of a hemispherical cylinder mounted in an elevation space of the liner, having an open upper part, and of which a diameter decreases toward a lower end and includes a variable part in which the hemispherical cylinder is vertically variable and an opening and closing protrusion configured to perform supply and blocking of a flow path.

A dispensing mechanism includes at least two helical augers having threads, and at least two channels configured to hold the items to be dispensed. The items to be dispensed are received at least partially within the threads of the augers. The dispensing mechanism includes a drive mechanism engaged with the at least two augers and configured to rotate the at least two augers to transport the items to be dispensed, driven by the threads of the augers, to dispense the items from the dispensing mechanism. The dispensing mechanism may include a separable dispenser and cassette.

The present invention relates, in some embodiments thereof, to systems, devices, connection ports, and methods allowing for an engagement of two or more pharmaceutical vessels, containers, or pharmaceutical administration devices in a decontaminated and/or sterile manner. In some embodiments of the invention, the systems, devices, connection ports, and methods of the invention include a dual decontamination action device having a wiping member and a removable sealing member, a system comprising a device having a wiping member and a removable sealing member and a connection port having a removable sealing member. A first removable sealing member attached to a housing of a device is provided, the housing further comprising a wiping member configured to move across the housing; and a connection port having a removable sealing member, both removable sealing members configured to displace from the engagement between the device and the connection port while a hermetically sealed connection is maintained between the device and the connection port. In some embodiments of the invention, the systems, devices, connection ports and methods include a wiping member that is configured to wipe off the surface(s) of the engaged device and connection port, thus providing a decontaminated/sterile fluid communication between the device and the connection port.

A device for delivery of a precise amount of pharmaceutical fluid to the eye is provided. The device includes an ampoule for storing a liquid and an aperture through which the liquid is discharged. The device further includes a vibrating membrane that includes a needle which protrudes from the membrane and extends to the aperture to form a needle valve. The needle valve provides hermetic closure of the aperture to enable preservative-free storage of the pharmaceutical fluid in the device. The system further includes an electromagnetic transducer to shift the membrane back and forth in order to discharge liquid through the nozzle. Finally, the system further includes a vent to permit air to enter the ampoule as fluid is ejected from the ampoule. Preferably this vent includes a filter to prevent ingress of microbes or other contaminants to the ampoule.

A device and method is disclosed for assembling a container holder in a clean environment, aseptically adding a solution to a primary container, inserting the primary container into the container holder, applying a first barrier to the container holder, sterilizing the container holder comprising the primary container and the applied first barrier to provide a sterilized container holder, assembling a fluid path module in a clean environment, the assembling comprising applying a second barrier to a first end of the sterilized fluid path module, sterilizing the fluid path module to provide a sterilized fluid path module and assembling a delivery device comprising the sterilized container holder and the sterilized fluid path module.