The invention relates to a method and to a device for filling a medical packaging formed as a pouch. Preferably, the packaging is filled with liquid via a port, wherein the port is aerated with a protective gas, such as nitrogen, for example, during filling According to the invention, prior to filling with liquid, the packaging is filled with an inert gas, such as nitrogen, for example, which then provides the headspace of the filled and closed pouch. This results in a particularly low oxygen content in the headspace of the pouch.

The present disclosure is directed to a midazolam pharmaceutical premix formulation housed in a flexible container, comprising from about 0.4 mg/ml to about 1.1 mg/ml midazolam hydrochloride and sodium chloride, wherein the formulation has a pH from about 2.7 to about 3.5. Also disclosed herein are methods of sedating a human subject in need thereof using the premix formulation.

A pharmaceutical premix formulation comprising from about 10 mcg/ml to about 70 mcg/ml epinephrine and a salt is described, wherein the formulation is an aqueous, premix formulation and has a pH from about 2 to about 6. Uses and systems including the epinephrine premix formulation are also provided.

A system including a vial and methods of its use to provide a lyophilized cake removable from the vial without cracking or breaking.

Apparatus and methods for lyophilizing and sealing a medicament within a medical delivery device having an opening. The apparatus may include a stopper for sealing the opening. The stopper may have one or more elongated members extending from a base, in a direction that is parallel to a central axis of the base. One or more of the members may be set radially away from the axis and define a coaxial central well. The member or members may define a void. The elongated member or members may engage a device inner wall and support the base away from the opening. The void may provide gas exchange between a device interior and a device exterior. The gas may be a lyophilization byproduct that escapes from the device interior between the inner wall, the base and the member or members. The stopper may be advanced into the device to seal the opening.

In order significantly to reduce the risk of contamination of a bag for medical purposes, in particular due to residual particles of tube material caused during cutting of a tube for access to the bag, the invention proposes a system (1) for producing a bag for medical purposes, comprising a tube transfer station (2) with a transfer means (3) for transferring a tube (11) coming into the tube transfer station (2) to a holder (10) and for the severing there of a tube section (17) transferred to the holder (10) from a remaining portion (18) of the incoming tube (11) in order subsequently to be able to make the severed tube section (17) connectable to two film layers for forming an access to the bag, wherein the tube transfer station (2) has a tube-tension-holding means (15) on the holder side and also a tube-pulling means (16), which means are designed to introduce tensile forces (19) between the severed tube section (17) and the remaining portion (18) of the incoming tube (11) while the severing takes place.

A blister package is provided that includes a base made from cyclic olefin copolymer (COC) and a lidding film that includes polyolefin layer(s) or a combination of polyolefin and COC layers, that allows both the lidding film and base to be recycled in a single plastic waste stream.

The present invention relates to compositions and methods for minimizing protein loss (e.g., due to adsorption to solid surfaces) at low protein concentrations. Inventions disclosed herein generally relate to the field of compositions comprising proteins, in particular, pharmaceutical compositions comprising therapeutic proteins at low protein concentrations. Inventions disclosed herein also relate to methods of administering the composition to a subject in need thereof.

Stabilized formulations of nucleic acids, including lipid nanoparticle formulations which encapsulate nucleic acids, are provided. Methods of making and of use of the formulations stabilized by chemical compounds are also provided.

The present disclosure describes a method that includes receiving a plurality of packaging units made of glass; coating at least a portion of an outer surface of each packaging unit with low-friction coating; curing the low-friction coating applied to the outer surface of each packaging unit; receiving a container configured to store the plurality of packaging units; and arranging each packaging unit in the container with the outer surface of each packaging unit able to touch the outer surface of one or more adjacent packaging units.