Provided is a sheet including a base material comprising a biocompatible material and having at least two independent holes, and a bioactive substance, wherein at least one of the independent holes is an independent hole A containing the bioactive substance, wherein at least one of the independent holes is an independent hole B containing no bioactive substance, wherein a maximum diameter of the independent holes is less than 0.2 mm. Also provided is a sheet laminate including sheets laminated with each other, wherein each of the sheets includes a base material comprising a biocompatible material and having at least two independent holes, and a bioactive substance, wherein at least one of the independent holes is an independent hole A containing the bioactive substance, wherein at least one of the independent holes is an independent hole B containing no bioactive substance.

An oral soluble film contains at least one active agent. Alternatively, a multi-layered film includes a plurality of layers, at least one at least one of the plurality of layers being an oral soluble film layer containing at least one active agent. The oral soluble film may be made, e.g., by a method comprising providing a well of a predetermined size; depositing a film forming composition in the well; metering a predetermined amount of an active agent composition in the well separately from the film forming composition, the active agent composition being different than the film forming composition, the film forming composition and the active agent composition forming a single layer in the well; and drying the single layer in the well to form the oral soluble film containing the at least one active agent.

A method of making a pharmaceutical composition for delivery to the lower respiratory tract via nebulization within a sterile diluent includes mixing dry powder ingredients including a beta agonist or anticholinergic and one or more additional ingredients to formulate a dry powder mixture for mixing with the sterile diluent.

Aspects of the present disclosure relate to a dispensing device capable of storing and dispensing strips/films. The dispensing device can deliver films of preselected length providing a predetermined medication dose, when required by user making it convenient for user to store, carry and administer the required doses. The dispensing device can allow retrieval and application of strips with minimal manipulation, permitting single-hand operation, thereby maintaining sterility of the strips/films. The dispenser can hold a pharmaceutical or herbal formulation on a suitable delivery material such as a film in roll form or cartridge form. The roll or the cartridge can last for number of doses sufficient for few days thus enabling a user to carry his medicine requirement in a convenient manner. Further, it provides hygienic storage and offers consistent and precise dispensing without user having to touch the thin film strip.

A system for dispensing oral consumables includes a mobile device and an oral consumables dispenser attached to the device. The dispenser can include a retractable holder for storing the oral consumables. As mobile electronic devices and their associated accessories are carried by most people for lengthy periods throughout the day, the system for dispensing oral consumables can facilitate timely consumption of oral consumables.

The single-dose container comprises a casing (1) that houses a product (2) and opening means (3), characterised in that said casing (1) is formed from gelatine, water and glycerine.

The manufacturing method comprises the following steps: mixing gelatine, water and glycerine; forming a film of said mixture; moulding said film to form two halves of a casing (1); and injecting a product (2) and sealing said two halves of the casing (1) at the same time, housing said product (2) inside the casing (1).

A biodegradable container is obtained, which self-recycles to the extent it is manufactured with biodegradable products, and a leakproof container, since it is hermetically sealed by welding when manufactured.

This present disclosure provides reliable methods and apparatus for delivering a pharmaceutical active ingredient to an edible substrate. In some examples, the pharmaceutical active ingredient is delivered to voids that are formed in the edible substrate. The voids can then be closed as desired. The edible substrate can be configured as a food product or a dosage form as desired.

A package, system and methods allow for custody and control of drugs, especially for an abuse-prone drug. A package for custody and control of a dose of an active agent, includes a unit dose of an active agent, and an individual package sealing the unit dose therein, the package having a custody and control product identifier unique to each unit dose provided on the package. A system for custody and control of a dose of an active agent, includes an individual package of one unit dose of an active agent, the package having a custody and control product identifier unique to each unit dose provided on the package, and a database containing data reflecting the custody and control identifier corresponding to each unit dose and an identifier configured to be able to identify the party to whom each unit dose is provided.

A package, system and methods allow for custody and control of drugs, especially for an abuse-prone drug. A package for custody and control of a dose of an active agent, includes a unit dose of an active agent, and an individual package sealing the unit dose therein, the package having a custody and control product identifier unique to each unit dose provided on the package. A system for custody and control of a dose of an active agent, includes an individual package of one unit dose of an active agent, the package having a custody and control product identifier unique to each unit dose provided on the package, and a database containing data reflecting the custody and control identifier corresponding to each unit dose and an identifier configured to be able to identify the party to whom each unit dose is provided.

Methods, systems and apparatuses are provided for producing delivery devices, preferably for oral intake of an agent. In the broadest aspect, the method comprises assembling one or more layers comprising one or more materials with an agent or an agent-releasing formulation to form an intergraded, preferably laminated device; folding said integrated delivery device to form a folded integrated delivery device; and at least partially enclosing said folded delivery device to a form suitable for oral delivery. Preferably, the integrated device comprise a first external layer of a first material; a frame of a second material mounted on the first external layer; an agent-releasing formulation housed within the frame; and a second external layer of the first material mounted on the frame.