Pharmaceutical compositions that include aqueous suspensions of therapeutically effective quantity of a diaminopyrimidine compound (such as pyrimethamine) are provided herein. Methods for fabricating and using the compositions, and kits that include the compositions are also described.

Chambered dispensing devices and methods for dispensing an amount of a preparation involve the use of a handheld dispensing system having a connecting body housing one or more preparation vials, a delivery spout, and a computer system or microprocessor controlled circuit that controls dispensing of the preparation(s), optionally in combination with a mobile application that allows an individual or user to interact with the chambered dispensing device via a mobile computing device, such as a smart phone. A mobile application can provide a graphic user interface that facilitates operation of the chambered dispensing device by the individual or user, optionally via dispensing device keypad buttons, to dispense micro-dose amounts of primary and secondary cannabinoids or other preparations or substances.

A cartridge pump according to the present invention includes: a housing unit connected to a container; a head unit rotatably provided in the housing unit; a storage unit provided in the head unit and having a storage space in which contents are stored; and a mixing operator configured to lead the contents in the storage unit into the container in cooperation with an operation of the head unit.

An apparatus to regulate the flow of a liquid from a container, dependent on nutritional requirements of a user stored within computer memory includes a container that comprises a bottom, a body and a lid, the lid including an opening therethrough, a straw or spout for removing the liquid from the container in the lid, a control assembly including a microprocessor, a liquid regulating valve, a port for communicating with an external computing device and source of electrical power. User nutritional information includes a personal profile, beverage list, nutrient limits and dietary, nutrition and hydration goals. Reference data includes beverage composition, recommended nutrient limits, and standards for determining liquid consumption. Sensors to determine temperature, volume, attitude and power level may be included. A method to regulate flow of a liquid from a container, dependent on the dietary, nutritional, medicinal and therapeutic requirements, and hydration goals of a user is disclosed.

A system for intraoral fluid delivery comprises a rate-controlled and/or volume-controlled fluid supply device, a reservoir for holding one or more fluids to be delivered to a patient's oral cavity, a mouthpiece to be worn by a patient at least partially within the patient's oral cavity, and tubing to carry the one or more fluids from the fluid supply device to the mouthpiece. The mouthpiece comprises a fluid inlet adjacent and/or exterior to the patient's oral cavity when the mouthpiece is worn by the patient, a fluid outlet posterior to the fluid inlet, and a fluid channel therebetween.

The present invention relates to a dispensing cap for the delivery of a fluid solubilisate, a beverage system configured for the use of such a dispensing cap and a method for preparing a beverage by means of such a beverage system. Poorly water-soluble dietary supplements or pharmaceutical active agents can be delivered in this new dosage form in order to increase the bioavailability of these substances. The solubilisate has been solubilized without a polysorbate.

A single-use nesting cup for use with mechanical comminution devices having a spinning drive mechanism for pulverizing pills into powder is disclosed. Each cup has a textured base surface that provides for a more efficient grinding and crushing of pills inserted between two such cups when an upper cup is spinningly brought to bear down on a bottom cup. The textured surface of each cup base has a symmetric three-dimensional wave design with each wave arcing along a curve from an outer cylindrical wall of the cup spiraling in toward a center point of the base of each cup. The crest and troughs of each wave act as grinding edges while the overall symmetric wave design acts to maintain the one or more pills and it's powdered form in the center of the bottom cup.

A method of forming a cap assembly comprises injection molding a cap in a first shot from a first polymeric material, wherein the cap has an opening at one end defined by a perimeter. Injection molding a tamper band in a second shot from a second polymeric material such that the tamper band is monolithically attached to the perimeter of the cap. The first polymeric material and the second polymeric material comprise dissimilar resins and the tamper band is configured to sever from the cap with no burrs remaining on the perimeter of the cap.

A method for treating a polymer vessel, comprising treating a surface region of the vessel by exposing the surface region to a high-frequency plasma; and coating the surface region of the vessel with a lasting water-based edible coating. A vessel treated in accordance with the method. The method may include placing the vessel on a conveyor, a robotic arm or system to facilitate the movement of the vessel through the high-frequency plasma device. Including rotating the vessel to treat different parts thereof.

A system for intraoral fluid delivery comprises a rate-controlled and/or volume-controlled fluid supply device, a reservoir for holding one or more fluids to be delivered to a patient's oral cavity, a mouthpiece to be worn by a patient at least partially within the patient's oral cavity, and tubing to carry the one or more fluids from the fluid supply device to the mouthpiece. The mouthpiece comprises a fluid inlet adjacent and/or exterior to the patient's oral cavity when the mouthpiece is worn by the patient, a fluid outlet posterior to the fluid inlet, and a fluid channel therebetween.