An electrospinning printing device and method thereof are disclosed. The device may comprise: a printing head arrangement configured to replaceably hold at least one printing head for discharging a fibrous material, and a collector arrangement configured to electrostatically attract material from the printing head, in which the collector arrangement may comprise an at least partially electrically insulated collector that is arranged to be connected to an electric power supply, and the at least one printing head is electrically grounded when held by the printing head arrangement.

Systems and methods are provided for fabricating microneedle arrays that includes electrospun fibers preferentially disposed within the microneedles of the array. Providing the electrospun fibers preferentially in the microneedles allows for more of a drug or other substance present in the fibers to be deposited into tissue or to provide other benefits. A mold for forming the microneedle arrays includes an insulating surface layer. The insulating surface layer affects the electric field during electrospinning such that electrospun fibers are deposited preferentially within the microneedle cavities of the mold relative to the surface of the mold. A bulk material can then be applied to the mold to form the bulk of the microneedles with electrospun fibers embedded within and a backing layer to which the microneedles are attached.

A method of forming an electrospun prosthetic valve includes utilizing a rotatable and angularly adjustable prosthetic valve mold. The prosthetic valve mold is set to a first angle. The prosthetic valve mold is rotated at a first rotational velocity and a first layer of electrospun fibers is deposited on the prosthetic valve mold. The prosthetic valve mold is stopped and a frame is positioned over the first layer. The prosthetic valve mold is set to a second angle. The prosthetic valve mold is rotated at a second velocity and a second layer of electrospun fibers is deposited on an outer surface of the first layer and an outer surface of the frame.

A system and method are provided for manufacturing filamentous polymer matrices, comprising electrospinning a polymer fiber into a gap between two or more spaced-apart electrodes.

A three-dimensional electrospun nanofiber scaffold for use in repairing a defect in a tissue substrate is provided. The scaffold includes a flexible deposited fiber network of varying density including a first and second set of set of electrospun fibers. The second set of electrospun fibers is coupled to the first. A first portion of the flexible deposited fiber network includes a higher density of fibers than a second portion of the flexible deposited fiber network, and the tensile strength of first portion is higher than that of the second portion. The scaffold is sufficiently flexible to facilitate application of scaffold to uneven surfaces of the tissue substrate, and enables movement of the scaffold by the tissue substrate. The first and second set of fibers are configured to degrade within three months after application, and each fiber of the deposited fiber network has a diameter of 1-1000 nanometers.

The present invention relates to a method for incorporating dye and/or nanoparticles into polymer films and into electrospun polymeric nanofibers, and, more specifically, to a method for electrospinning a molecularly homogenous solution of dye (and/or nanoparticles) and polymer dissolved in a mutual solvent leading to uniform distribution of dye across the cross-section of each constituent fiber and to resulting nanofibers with the dye/nanoparticles incorporated therein.

The instant disclosure is directed to methods of promoting the healing of concave wounds. A method for promoting the healing of a concave wound may comprise placing a scaffold over the concave wound, the scaffold comprising an electrospun polymer fiber. The scaffold may be pressed into the concave wound, such that the scaffold simultaneously contacts at least a bottom portion of the concave wound and at least a side portion of the concave wound. The method may be suture free. The scaffold employed in such a method may have an asterisk shape comprising a center and at least two spokes, and pressing the scaffold into the concave wound may comprise pressing the center of the scaffold into the bottom portion of the concave wound, and allowing the at least two spokes of the scaffold to fold upward to contact the side portion of the concave wound.

According to one embodiment, an electrospinning apparatus is adapted to deposit fibers on a member to form a deposited body. The apparatus includes a processing section. The processing section is capable of forming a mixture section in the deposited body. A first fiber part of the deposited body, and a second fiber part of the deposited body are mixed with each other in the mixture section. The first fiber part is located on the member. The second fiber part is located on the first fiber part.

A medical appliance or prosthesis may comprise one or more layers of electrospun nanofibers, including electrospun polymers. The electrospun material may comprise layers including layers of polytetrafluoroethylene (PTFE). Electrospun nanofiber mats of certain porosities may permit tissue ingrowth into or attachment to the prosthesis.

A cam-driven wire mesh-type electrospinning apparatus and a use method therefor are provided. The cam-driven wire mesh-type electrospinning apparatus includes the following components: a high-voltage (HV) power supply unit, a wire mesh-type spinneret, a fiber receiving device, a cam unit, and a solution supply unit. The positions and connection relationships of all the components are as follows: any end of the wire mesh-type spinneret is connected to the HV power supply unit, and the other end of the wire mesh-type spinneret is connected to the cam unit; the wire mesh-type spinneret is installed on the solution supply unit; and the fiber receiving device is positioned right above the wire mesh-type spinneret. The cam-driven wire mesh-type electrospinning apparatus may induce a solution to be uniformly distributed on a wire mesh plane, and adjust the density of jet flow and the distribution position of the jet flow.