A method for producing a sheet having nanofibers that contain a piezoelectric polymer material. The method including dissolving a piezoelectric polymer material into a solvent so as to prepare a spinning solution; preheating a target board before nanofibers are formed by electrospinning the spinning solution; and, after the heating of the target board, receiving the nanofibers formed by electrospinning onto the heated target board so as to form the nanofibers into a sheet on the heated target board.

A three-dimensional electrospun biomedical patch includes a first polymeric scaffold having a first structure of deposited electrospun fibers extending in a plurality of directions in three dimensions to facilitate cellular migration for a first period of time upon application of the biomedical patch to a tissue, wherein the first period of time is less than twelve months, and a second polymeric scaffold having a second structure of deposited electrospun fibers. The second structure of deposited electrospun fibers includes the plurality of deposited electrospun fibers configured to provide structural reinforcement for a second period of time upon application of the three-dimensional electrospun biomedical patch to the tissue wherein the second period of time is less than twelve months. The three-dimensional electrospun biomedical patch is sufficiently pliable and resistant to tearing to enable movement of the three-dimensional electrospun biomedical patch with the tissue.

Provided is an electrospinning alignment apparatus enabling mass production of nanofiber membranes by simultaneously nanofibers that are spun in alignment in one direction on a transferred carrier and nanofibers that are randomly spun.

Disclosed is a system and a method for electrospinning superfine fiber bundling, belonging to the technical field of artificial fiber manufacturing, and comprises a spinning nozzle and a bundling disk which are coaxially arranged; the spinning nozzle is arranged at an upper part of the bundling disk; the bundling disk is connected with a motor through a coupling; the motor rotates to drive the bundling disk to rotate; a guide groove is also arranged outside the bundling disk; a center of the bundling disk is provided with a shaft; the insulated outer ring, the central conductive ring, the insulated inner ring and the shaft are fixed by bonding or thermal compounding; inner and outer edges of the central conductive ring are smooth circular arc rounded corners; an inner edge of the insulated outer ring and an outer edge of the insulated inner ring are corresponding smooth rounded corners.

A composite multi-layer textile, comprising at least one nanofibre layer with nanofibres with diameters below 100 nm and one support layer with microfibres with diameters below three microns, wherein the layers were produced by electrospinning. The multi-layer textile shows a general transmittance at #=550 nm greater than 60%, which shows improved properties concerning transparency, breathability and robustness. This is achieved in that the at least one nanofibre layer and the support layer are fused, forming solid domains in the multi-layer textile, at closed areas of a pattern used in the production process, wherein the solid domains are separated from each other or connected, showing defined shapes, with regular or irregular spatial distribution, while the fibre morphology of nanofibres of the nanofibre layer and microfibres of support layer is preserved on top of the open areas beside the solid domains, attaining a general transmittance greater than that given by the sum of the individual layers.

It has been established that optimizing cell seeding onto tissue engineering vascular grafts (TEVG) is associated with reduced inflammatory responses and reduced post-operative stenosis of TEVG. Cell seeding increased TEVG patency in a dose dependent manner, and TEVG patency improved when more cells were seeded, however duration of incubation time showed minimal effect on TEVG patency. Methods of engineering patient specific TEVG including optimal numbers of cells to maintain graft patency and reduce post-operative stenosis are provided. Closed, single-use customizable systems for seeding TEVG are also provided. Preferably the systems are custom-designed based on morphology of the patient specific graft, to enhance the efficacy of cell seeding.

A device having: an article having a flat surface and a lower surface opposed to the flat surface; a cavity formed in the lower surface forming a complete loop surrounding a central portion of the article; a heating element having the same shape as the complete loop in the cavity and positioned to warm a portion of the flat surface adjacent to the heating element when the heating element is activated; a cooling device positioned to cool a portion of the flat surface in the central portion; and a release layer on the flat surface. A device having: an article having an upper surface; a heating element on the upper surface forming a complete loop surrounding a central portion of the article; and an electrically insulating material on the upper surface within the central portion.

A device for treating a damaged tissue includes an expandable scaffold positionable in a portion of a luminal tissue structure of a mammal; and maintained via stent technology, wherein the scaffold is comprised of electrospun fibers composed of a biodegradable compound. The scaffold serves as a temporary template that allows the tissue to be rebuilt.

According to one embodiment, an electrospinning apparatus is adapted to deposit fibers on a member to form a deposited body. The apparatus includes a processing section. The processing section is capable of forming a mixture section in the deposited body. A first fiber part of the deposited body, and a second fiber part of the deposited body are mixed with each other in the mixture section. The first fiber part is located on the member. The second fiber part is located on the first fiber part.

A medical appliance or prosthesis may comprise one or more layers of electrospun nanofibers, including electrospun polymers. The electrospun material may comprise layers including layers of polytetrafluoroethylene (PTFE). Electrospun nanofiber mats of certain porosities may permit tissue ingrowth into or attachment to the prosthesis.