A Smart Medication Adherence Refrigeration Tray (SMART) along with method of use to assist with self-management of medication treatment by patients. The SMART medication tray accepts a plurality of medication filled containers of various sizes along with individual storage compartments for each container. Each medication storage compartment uses an embedded scale mechanism to monitor the amount of medication being taken by the patient and to assist with the medication adherence compliance. A series of optical sensors are utilized to detect when medication bottles are placed on the storage compartment as well as when they are being removed. Medication tray utilizes wireless technology to interactively communicate with outside computing devices to receive medication prescription and assist with the adherence process.

The phase-change accommodating rigid fluid container disclosed herein includes a variety of features that protect the container from phase changes of a fluid stored therein. As a result, the container may be in direct contact with the fluid without any flexible membrane or bag there between. For example, the fluid container may include one or more of matched pairs of recesses for physical manipulation of the container, stiffening ribs extending between the recesses, and input/output assemblies acting as inputs for fluid into the container, outputs of fluid from the container, and vents for pressure equalization of the container.

This invention relates to an apparatus and method for applying writings and other markings to a frozen vial or ampoule, which is filled with biological material, and which is held at temperatures between about 70 C. and about 196 C. More particularly, the invention relates to a laser marking method that allows frozen vials to be labeled, while maintaining the integrity of the biological material contained therein.

A case includes a pocket for hermitically storing medical device(s) and medicine. The case may include a manual or motorized pump that can generate vacuum pressure within the pocket to thermally insulate the pocket from the atmosphere to minimize temperature fluctuations within the pocket. The case may also include a cooling and/or heating system to control the temperature within the pocket within a desired range to prolonging the potency and the life expectancy of the drug, such as epinephrine, stored within the pocket. The case may also be equip with a communication device that can link with user's mobile device so that in case of an emergency, the communication device can alert the mobile device, which can then notify emergency personal for assistance.

In some embodiments, alerts are sent to appropriate parties if an insulated container is not properly packed out to insure the approximate safe temperature of the materials. In other embodiments, a countdown timer is used to keep track of the time that the biologic has been in transit, and ensure that the amount of time does not exceed the known shelf life of the biologic. In still other embodiments, the payload container is equipped with its own sensors, such as temperature sensors, and communications devices, such as a close range communication device, capable of transmitting information regarding a range of parameters, including, but not limited to, temperature, humidity, location and time, from the payload container to an end user. In other embodiments, shielding and/or radiation sensors are included in insulated shipping or storage containers, or payload containers, to shield and monitor the radiation exposure of the payload.

A production line is, suitable for the production of medicinal products that include at least one active ingredient. The production line includes an extruder for producing an extrudate from the active ingredient and at least one excipient intended to form an encapsulating matrix of the active ingredient, and a cooling member for cooling the extrudate at the outlet of the extruder. The extruder includes a barrel and at least two parallel screws housed in the barrel and interpenetrating with one another to mix the or each active ingredient with the or each excipient. The barrel is oriented vertically and the footprint occupied by the production line is less than 0.5 m.sup.2.

In some embodiments, alerts are sent to appropriate parties if an insulated container is not properly packed out to insure the approximate safe temperature of the materials. In other embodiments, a countdown timer is used to keep track of the time that the biologic has been in transit, and ensure that the amount of time does not exceed the known shelf life of the biologic. In still other embodiments, the payload container is equipped with its own sensors, such as temperature sensors, and communications devices, such as a close range communication device, capable of transmitting information regarding a range of parameters, including, but not limited to, temperature, humidity, location and time, from the payload container to an end user. In other embodiments, shielding and/or radiation sensors are included in insulated shipping or storage containers, or payload containers, to shield and monitor the radiation exposure of the payload.

In some embodiments, alerts are sent to appropriate parties if an insulated container is not properly packed out to insure the approximate safe temperature of the materials. In other embodiments, a countdown timer is used to keep track of the time that the biologic has been in transit, and ensure that the amount of time does not exceed the known shelf life of the biologic. In still other embodiments, the payload container is equipped with its own sensors, such as temperature sensors, and communications devices, such as a close range communication device, capable of transmitting information regarding a range of parameters, including, but not limited to, temperature, humidity, location and time, from the payload container to an end user. In other embodiments, shielding and/or radiation sensors are included in insulated shipping or storage containers, or payload containers, to shield and monitor the radiation exposure of the payload.

A case for transporting a substance such as a messenger RNA vaccine, including a container, a damping material contained in the container and a storage structure immersed in the damping product, the storage structure forming cavities for receiving syringes containing said substance.

The disclosure relates to an artificial intelligence (AI)-based medicine storage cabinet capable of reminding a user of a medication time. More specifically, the AI-based medicine storage cabinet may include a main body having a door formed on an exterior thereof to be opened and closed, and storing a medicine therein, a controller operably provided in the main body to alert a user of a medication time according to a set time, and a refrigerator adjusting an internal temperature of the main body under the control of the controller. The main body may include a first space and a second space independent of each other by a first partition wall, and the refrigerator may individually control internal temperatures of the first space and the second space by a set algorithm of the controller.