Provided herein are high performance dental restoration compositions, particularly two-part compositions having good self-cure times. Also provided herein are methods for restoring or filling a cavity in a tooth in an individual with the two-part dental restoration compositions. In particular, compositions provided herein are useful in restoring large cavities, including Class I and Class II cavities.

Provided herein are high performance dental restoration compositions, particularly two-part compositions having good self-cure times. Also provided herein are methods for restoring or filling a cavity in a tooth in an individual with the two-part dental restoration compositions. In particular, compositions provided herein are useful in restoring large cavities, including Class I and Class II cavities.

Provided is a dental curable composition containing: (A) a porous organic-inorganic composite filler which comprises an organic resin component obtained by polymerizing a polymerizable monomer component (a) including at least 50 mass % of a polymerizable monomer having a hydrogen-bonding functional group, and an inorganic component composed of a plurality of inorganic particles; (B) a polymerizable monomer component including at least 10 mass % of a polymerizable monomer having a hydrogen-bonding functional group; and (C) a polymerization initiator, wherein (C) the polymerization initiator comprises, as photopolymerization initiators, (c1) a photosensitizer compound, (c2) a reducing agent, and (c3) a photoacid generator composed of an aryliodonium salt compound, and the content of the aryliodonium salt compound is 0.1-5 parts by mass with respect to 100 parts by mass of the total mass of (B) the polymerizable monomer component.

Provided is a dental curable composition containing: (A) a porous organic-inorganic composite filler which comprises an organic resin component obtained by polymerizing a polymerizable monomer component (a) including at least 50 mass % of a polymerizable monomer having a hydrogen-bonding functional group, and an inorganic component composed of a plurality of inorganic particles; (B) a polymerizable monomer component including at least 10 mass % of a polymerizable monomer having a hydrogen-bonding functional group; and (C) a polymerization initiator, wherein (C) the polymerization initiator comprises, as photopolymerization initiators, (c1) a photosensitizer compound, (c2) a reducing agent, and (c3) a photoacid generator composed of an aryliodonium salt compound, and the content of the aryliodonium salt compound is 0.1-5 parts by mass with respect to 100 parts by mass of the total mass of (B) the polymerizable monomer component.

The present invention relates to methods and compositions for treating pulmonary infection. In particular, the present invention provides nanoemulsion compositions and methods of using the same to treat bacteria associated with biofilms (e.g., found in pulmonary infections). Compositions and methods of the present invention find use in, among other things, clinical (e.g. therapeutic and preventative medicine), industrial, and research applications.

Provided is an implantable composite which includes a plurality of resorbable ceramic particles with or without a biodegradable polymer. The resorbable ceramic particles can be granules including carbonated hydroxyapatite and tricalcium phosphate in a ratio of 5:95 to 70:30. Some resorbable ceramic particles are granules, which include carbonated hydroxyapatite and β tricalcium phosphate in a ratio of 5:95 to 70:30. The resorbable ceramic particles have a particle size from about 0.4 to about 3.5 mm. The implantable composite is configured to tit at or near a bone defect as an autograft extender to promote bone growth. Methods of using the implantable composite are also provided.

The present invention provides a dental adhesive kit including a bonding material that has a good state stability, that has a good balance between photocurability for LED light irradiation and stability to ambient light, and that is capable of exhibiting high bond strengths to both enamel and dentin with small variability even when subjected to photocuring with a high-power LED irradiation device. The present invention relates to a dental adhesive kit including a primer and a bonding material. The primer includes an acid group-containing monomer, a hydrophilic monomer, and water, and the bonding material includes a hydrophilic monomer (B-1), an aromatic bifunctional monomer (B-2), an aliphatic bifunctional monomer (B-3), α-diketone (B-4), (bis)acylphosphine oxide (B-5), and a benzotriazole compound (B-6) as defined in the description. The content of (B-4) is 0.6 to 2 parts by weight per part by weight of (B-5), and the content of (B-6) is 0.01 to 3 parts by weight per 100 parts by weight of (B-3).

A phosphorous compound such as STMP is used as a cross-linking agent while making a starch nanoparticle in an emulsion process. Negative charge of the nanoparticle is reduced or reversed by adding cations and/or cationizing the starch optionally while forming the nanoparticles. Anionic active agents, such as fluoride or fluorescein, are optionally incorporated into the nanoparticle during the formation process. For example, a fluoride salt can also be used, which promotes the crosslinking reaction while also providing fluoride in the nanoparticle. The retention of both calcium and fluoride in the nanoparticle is improved when both salts are used. Alternatively, the nanoparticle may be used without added calcium and/or fluoride. The nanoparticles may be useful for tooth remineralization, the treatment of dentinal hypersensitivity, to treat caries, or as a diagnostic agent to locate carious lesions.

The invention relates to a dental composition comprising filler (F1) comprising aggregated nano-sized particles in an amount of from about 30 to about 70 wt. %, filler (F2) comprising agglomerated nano-sized particles in an amount from about 1 to about 20 wt. %, hardenable component (A1) being an urethane(meth)acrylate with a functionality of at least 2 and having a molecular weight from about 400 to about 3,000 g/mol,-hardenable component (A2) being a radically polymerizable (meth)acrylate with a functionality of at least 2 being different from component (A1), redox curing initiator system, the dental composition not comprising non-agglomerated nano-sized filler in an amount above about 10 wt. %, wt. % with respect to the weight of the whole composition. The dental composition is in particular useful as or for production of permanent crown and bridges, inlays, onlays and veneers.

Provided are metal oxide ceramic materials and intermediate materials thereof (e.g., nanozirconia gels, nanozirconia green bodies, pre-sintered ceramic bodies, zirconia dental ceramic materials, and dental articles). The nanozirconia gels are formable gels. Also provided are methods of making and using the metal oxide materials and intermediate materials. The nanozirconia gels can be made using, for example, osmotic processing. The nanozirconia gels can be used to make nanozirconia green bodies, pre-sintered ceramic bodies, zirconia dental ceramic materials, and dental article. The nanozirconia green bodies, pre-sintered ceramic bodies, zirconia dental ceramic materials, and dental articles have desirable properties (e.g., optical properties and mechanical properties).