Methods for enhancing or accelerating osseointegration of an implant into bone marrow of a subject, the methods comprising increasing expression of peripheral clock neuronal PAS domain protein 2 (NPAS2) in the bone marrow, are provided. Expression of NPAS2 is increased by administration of a Npas2 modulating compound to the subject.

The invention relates to calcium coacervate for use in a method for caries prevention and/or caries treatment, comprising a step during which dental enamel is infiltrated with calcium coacervate; and to kits that comprise: a) a phosphate ion-containing solution; and b1) a calcium coacervate-containing emulsion and/or b2) a second solution comprising polyanions and/or their salts, and a calcium ion-containing third solution.

The invention relates to calcium coacervate for use in a method for caries prevention and/or caries treatment, comprising a step during which dental enamel is infiltrated with calcium coacervate; and to kits that comprise: a) a phosphate ion-containing solution; and b1) a calcium coacervate-containing emulsion and/or b2) a second solution comprising polyanions and/or their salts, and a calcium ion-containing third solution.

To provide a liquid for improving translucency for dental zirconia calcined body which may impart high translucency which is similar to an enamel of a natural tooth to a zirconia sintered body and a method for using thereof.

The liquid for improving translucency for dental zirconia calcined body of the present disclosure contains a solvent and an indium compound, wherein a content of the indium compound based on the total amount of the liquid improving translucency for dental zirconia calcined body is within a range of 2.0 wt. % to 20.0 wt. % in terms of indium.

To provide a liquid for improving translucency for dental zirconia calcined body which may impart high translucency which is similar to an enamel of a natural tooth to a zirconia sintered body and a method for using thereof.

The liquid for improving translucency for dental zirconia calcined body of the present disclosure contains a solvent and an indium compound, wherein a content of the indium compound based on the total amount of the liquid improving translucency for dental zirconia calcined body is within a range of 2.0 wt. % to 20.0 wt. % in terms of indium.

An inorganic-organic composite medical material includes a two-phase co-continuous structure of an inorganic substance having open pores and an organic polymer filling the open pores, wherein the open pores have an average pore diameter of 1 nm or more and 100 nm or less, and the inorganic substance has a specific surface area of 100 m.sup.2/g or less.

An inorganic-organic composite medical material includes a two-phase co-continuous structure of an inorganic substance having open pores and an organic polymer filling the open pores, wherein the open pores have an average pore diameter of 1 nm or more and 100 nm or less, and the inorganic substance has a specific surface area of 100 m.sup.2/g or less.

A titanium dioxide (TiO.sub.2) composition and methods of use, the composition containing surface-modified doped TiO.sub.2 nanoparticles (sm-TiO.sub.2 NP.sub.s) disposed in a polymer matrix material, wherein each sm-TiO.sub.2 NP has an outer surface having a plurality N of bifunctional linker molecules attached thereto and a plurality of protein molecules linked to the sm-TiO.sub.2 NP via the bifunctional linker molecules; and wherein the polymer matrix comprises a polymer precursor component.

A titanium dioxide (TiO.sub.2) composition and methods of use, the composition containing surface-modified doped TiO.sub.2 nanoparticles (sm-TiO.sub.2 NP.sub.s) disposed in a polymer matrix material, wherein each sm-TiO.sub.2 NP has an outer surface having a plurality N of bifunctional linker molecules attached thereto and a plurality of protein molecules linked to the sm-TiO.sub.2 NP via the bifunctional linker molecules; and wherein the polymer matrix comprises a polymer precursor component.

The present disclosure provides a dental implant configured to be inserted in a hole in jaw bone and to be at least partially situated in the bone tissue when implanted and includes: a coronal region, an apical region, a longitudinal axis extending from the coronal region of the dental implant to the apical region of the dental implant; an implant surface configured to form an interface between an implant material and the oral environment/surrounding tissue and a surface layer formed on at least part of the implant surface, the surface layer including crystalline titanium oxide in the anatase phase and wherein the surface area roughness Sa and the pore size of the implant surface on which said surface layer is formed increase from the coronal region toward the apical region of the dental implant along the longitudinal axis.