The present invention relates to a composition for skin external application. Specifically, a composition for skin external application comprising a stably formed lamella liquid crystal phase can be provided according to the present invention. In addition, according to the present invention, the composition can provide excellent skin moisturizing and skin barrier strengthening effects upon application on the skin, as well as act effectively as an agent for a cannabinoid type 1 receptor, such that it is expected that the present invention can provide a very effective effect for treatment or improvement of skin diseases and mental disorders associated with skin diseases.

The invention provides a topical o/w emulsion which moisturizes, and protects, repairs or restores the skin lipid barrier of a mammal. The topical o/w emulsion composition comprises:

(a) a discontinuous oil phase;

(b) a continuous aqueous phase comprising water;

(c) a thickening agent;

(d) at least one lamellar membrane structure comprising (i) a phospholipid, (ii) a fatty alcohol, and (iii) a fatty acid; and

wherein in use the composition has a water vapor transmission rate of less than about 70 g.m.sup.2.hr.sup.1 measured in vitro using the modWVTR test methodology.

The present disclosure provides a chlorhexidine-cyclamate complex having a formula [C.sub.22H.sub.32Cl.sub.2N.sub.10][C.sub.6H.sub.12NO.sub.3S].sub.2 having antibacterial and antiplaque properties, together with oral care compositions comprising the complex, and methods of making and using these complexes and compositions.

A substantially anhydrous cosmetic composition having a lamellar network including: (a) about 20 to about 84.5 wt. % of one or more glycols chosen from ethylene glycol, propylene glycol, butylene glycol, hexylene glycol, pentylene glycol, diethylene glycol, dipropylene glycol, 1,3 propanediol, polyethylene glycols, and a mixture thereof; (b) about 15 wt. % to about 50 wt. % of one or more trihydric alcohols having from 3 to 5 carbon atoms; wherein the total amount of the one or more glycols of (a) is greater than the total amount of the one or more trihydric alcohols of (b); (c) about 0.1 to about 5 wt. % of one or more cationic surfactants; (d) about 0.1 to about 5 wt. % one or more alkoxylated fatty alcohols; and (e) about 0.1 to about 10 wt. % of one or more fatty alcohols, wherein all percentages by weight are based on the total weight of the cosmetic composition.

The present invention is directed to a method for improving the occlusiveness of a topical pharmaceutical or cosmetic formulation in use in a patient in need thereof, comprising adding to the formulation at least 0.1- to about 10% w/w of one or more of a monofatty acid ester of glycerin and/or one or more of a monofatty acid ester of glycol, or mixtures thereof.

The present invention is also directed to a method for maintaining skin barrier efficiency of the stratum corneum of a patient in need thereof, comprising applying to the skin of said patient a pharmaceutical or cosmetic formulation containing at least 3% w/w of one or more of a monofatty acid ester of glycerin and/or one or more of a monofatty acid ester of glycol, or mixtures thereof.

An antiperspirant composition comprising ethanol, amphiphilic material and volatile silicone, the amphiphilic material being a substance or mixture of substances which forms, upon contact with perspiration, a water-insoluble liquid crystal phase of greater than one dimensional periodicity, wherein: (i) the ratio of amphiphilic material to (ethanol+volatile silicone) is greater than or equal to 1:9; (ii) the ratio of volatile silicone to (ethanol+amphiphilic material) is from 1:9 to 1:1 and wherein (iii) the ratio of ethanol to amphiphilic material is greater than or equal to 7:3.

The invention provides for a topical o/w emulsion having moisturizing, and protecting, repairing or restoring the skin lipid barrier of the lips of a mammal, and is a topical oil-in-water emulsion composition comprising: (a) a discontinuous oil phase; (b) a continuous aqueous phase comprising water; (c) a thickening agent; (d) at least one lamellar membrane structure comprising (i) an alkyl amphiphilic component, (ii) an ester of a branched fatty acid and a branched fatty alcohol, (iii) a fatty acid, (iv) a fatty alcohol, and optionally (v) a phospholipid; and
wherein in use the composition has a water vapor transmission rate of less than 65 g.Math.m.sup.2.Math.hr.sup.1 measured in vitro.

The present invention relates to a cosmetic composition of a multiple emulsion formulation having a lamellar liquid crystal structure, and a method for preparing the same. More particularly, the cosmetic composition is prepared using different single emulsification type emulsions, i.e. a W/O type emulsion and an O/W type emulsion which has a lamellar liquid crystal structure, or using a mixture having constituent ingredients thereof. Thus, the present invention has effects of stably maintaining effective ingredients of the cosmetic composition, and enhancing the feeling of use.

Disclosed are semi-solid gel compositions comprising (a) a gelling oil phase comprising: i) at least one oil gelator; ii) at least one fatty alcohol; and iii) at least one fatty compound other than (ii); wherein said gelling oil phase is present in an amount of from at least about 50% by weight, relative to the weight of the total composition; and (b) a lamellar crystalline aqueous gel phase comprising: i) water and optionally at least one polyol present in an amount up to about 50% by weight, relative to the weight of the total composition; ii) at least one lamellar crystalline phase structurant; and iii) at least one emulsifier. The disclosure also relates to methods of treating keratinous substrates.

The present invention provides a cosmetic composition comprising a cholesteric liquid crystal particle having an average diameter of 50 m to 500 m and a method for preparing the same. Since the cosmetic composition according to the present invention comprises a cholesteric liquid crystal particle having a controlled average particle diameter and a narrow particle size distribution, the expression of visual dependence of changing color or color tone according to a viewing angle is enhanced.