A composition comprising at least three probiotic microorganisms, at least three prebiotic compounds, and polymnia sonchifolia root juice. The probiotic microorganisms are preferably derived from at least lactococcus lactis, lactobacillus acidophilus, and lactobacillus casei. The prebiotic compounds are preferably derived from at least curcuma longa (turmeric) root extract, beta vulgaris (beet) root extract, and chicory root extract. The composition may also include lactic acid as a byproduct of fermentation by lactococcus lactis. The composition may be encapsulated allowing it to adhere to and remain on the skin more effectively and longer than without encapsulation.

A polymeric composition for enhancing grip, including a modified solvent phase and a solid phase dispersed within the modified solvent phase. The modified solvent phase may include calcium-based gel, including calcium acetate particles partially dissolved in an alcoholic solution. The solid phase also includes a polymeric matrix and a plurality of desiccant particles encompassed by the polymeric matrix. The polymeric matrix includes polyvinyl acetate (PVAc) and a thickener.

The present invention relates to pre-formulations comprising low viscosity, non-liquid crystalline, mixtures of: a) at least one neutral diacyl lipid and/or at least one tocopherol; b) at least one phospholipid; c) at least one biocompatible, oxygen containing, low viscosity organic solvent;
wherein at least one bioactive agent is dissolved or dispersed in the low viscosity mixture and wherein the pre-formulation forms, or is capable of forming, at least one liquid crystalline phase structure upon contact with an aqueous fluid. The preformulations are suitable for generating parenteral, non-parenteral and topical depot compositions for sustained release of active agents. The invention additionally relates to a method of delivery of an active agent comprising administration of a preformulation of the invention, a method of treatment comprising administration of a preformulation of the invention and the use of a preformulation of the invention in a method for the manufacture of a medicament.

The present invention belongs to the fields of pharmaceuticals and cosmetics, and concerns on the one hand a medicament for the inhibition of and refers also on the cosmetic, non-therapeutic use for the treatment of hyperpigmentation, particularly induced by sun light radiation, preferably induced by visible light radiation.

Methods and compositions for delivering medicine and other substances to the brain and the body via the cribriform plate using foamable compositions are described. Methods and compositions for improving nasal hygiene and moisturizing the nasal cavity using foamable compositions are also described.

Evaporation of water from an aqueous dispersion of a solid peroxide such as benzoyl peroxide is retarded by the incorporation of carboxylic acid salt. The carboxylic acid salt renders the aqueous dispersion less susceptible to explosive decomposition when exposed to external triggering events such as impact, heat, friction or contamination, yet does not interfere with the ability to achieve and maintain a stable, small particle size dispersion having desirable viscosity and flow properties.

Compositions and devices are described that provide controlled release of beneficial bacteria to the oral cavity. Such bacteria can subsequently colonize the oral cavity and displace or suppress the growth of pathogenic microorganisms. Described devices include a stabilized preparation of such beneficial bacteria and provide a consumable liquid, wet foam, or gel that includes such bacteria when used.

Semisolid oral dispersions for improving the health and/or appearance of the oral cavity. The semisolid oral dispersions include hydrophilic active agent particles in hydrophobic phase. The hydrophilic active agent particles can include bleaching agents, antimicrobial agents, anticalculus agents, and/or combinations thereof. The hydrophilic active agent particle can have a solubility in water of at least about 20 parts, by weight of the particles, in about 100 parts, by weight, of water.

Semisolid oral dispersions for improving the health and/or appearance of the oral cavity. The semisolid oral dispersions include hydrophilic active agent particles in hydrophobic phase. The hydrophilic active agent particles can include bleaching agents, antimicrobial agents, anticalculus agents, and/or combinations thereof. The hydrophilic active agent particle can have a solubility in water of at least about 20 parts, by weight of the particles, in about 100 parts, by weight, of water.

A composition configured for topical application to the skin and formulated to reduce itching and inflammation is provided. The composition comprises a solution of vinegar, alcohol, and vegetable glycerin together with certain combinations of raw plant materials selected from rosemary, lavender, lemongrass, bergamot, aloe vera, ginger root, roman chamomile, nutmeg, parsley leaf, orange peel, and grapefruit peel. The solution including raw plant material may be periodically stirred over a period of weeks or months to mix ingredients and facilitate fermentation and microorganism activity. When applied to the skin, the nutrient density of beneficial microorganisms on the skin, including certain biproducts of the fermentation, may be increased to improve the skins acceptance and absorption of such microorganisms and byproducts.