The present application provides a method for preparing mesenchymal stem cell-derived exosomes, the method including: obtaining a cell sample from mesenchymal stem cells and sub-culturing the cell sample, culturing the sub-cultured cells in a substrate medium containing a protein synthesis inhibitory enzyme, and then obtaining a cell culture solution, and isolating exosomes from the cell culture solution, and a cell culture solution produced therefrom. The method for preparing exosomes of the present application has an advantage in that high purity and high concentration exosomes can be isolated.

The present application provides a method for preparing mesenchymal stem cell-derived exosomes, the method including: obtaining a cell sample from mesenchymal stem cells and sub-culturing the cell sample, culturing the sub-cultured cells in a substrate medium containing a protein synthesis inhibitory enzyme, and then obtaining a cell culture solution, and isolating exosomes from the cell culture solution, and a cell culture solution produced therefrom. The method for preparing exosomes of the present application has an advantage in that high purity and high concentration exosomes can be isolated.

The present disclosure relates to a composition containing extracellular vesicles isolated from skeletal muscle-derived stem cells as active ingredients, which exhibits the effect of skin aging delay, wound healing, scar reduction and skin whitening, thereby improving skin condition. The present disclosure can not only utilize tissues wasted after surgical operation, thus allowing easy supply of raw materials, but also takes advantage of natural substances, thereby being free from the risk of side effects even upon long-term administration. The composition of the present disclosure promotes the secretion of collagen, reduces reactive oxygen species and promotes re-epithelialization at wound site while remarkably inhibiting melanocyte proliferation, tyrosinase activity and melanogenesis. Accordingly, it can facilitate effective recovery from skin tissue damage caused by oxidative stress, physical wound, intrinsic aging at cell or tissue levels, or hyperpigmentation.

The present invention relates to a retinal-containing multilamellar vesicle and, more specifically, to a retinal-containing multilamellar vesicle comprising 0.01-5% by weight of retinal, 0.1-10% by weight of rapeseed sterol, 0.1-10% by weight of phytosteryl/behenyl/octyldodecyl lauroyl glutamate, 0.1-8% by weight of polyglyceryl-10 oleate, 0.1-10% by weight of cholesterol, 0.01-5% by weight of hydrogenated lecithin, 0.01-5% by weight of ceramide, 1-15% by weight of squalane, 0.1-10% by weight of vegetable butter, 3-30% by weight of oily liquid, 1-20% by weight of glycerin, and 30-70% by weight of water, and to a cosmetic composition comprising same.

The present invention relates to a retinal-containing multilamellar vesicle and, more specifically, to a retinal-containing multilamellar vesicle comprising 0.01-5% by weight of retinal, 0.1-10% by weight of rapeseed sterol, 0.1-10% by weight of phytosteryl/behenyl/octyldodecyl lauroyl glutamate, 0.1-8% by weight of polyglyceryl-10 oleate, 0.1-10% by weight of cholesterol, 0.01-5% by weight of hydrogenated lecithin, 0.01-5% by weight of ceramide, 1-15% by weight of squalane, 0.1-10% by weight of vegetable butter, 3-30% by weight of oily liquid, 1-20% by weight of glycerin, and 30-70% by weight of water, and to a cosmetic composition comprising same.

Method for remineralizing teeth or increasing hardness of tooth enamel by application of Brazilian green propolis oil or its components.

Method for remineralizing teeth or increasing hardness of tooth enamel by application of Brazilian green propolis oil or its components.

A topical composition comprising an aqueous-based composition comprising cannabinoids, in particular cannabidiol, in niosomes having size lower than 500 nm, and at least one topically acceptable excipient, characterized in that said niosomes comprise (i) at least one linear or branched polyglycerol, esterified with saturated or monounsaturated linear fatty acids, (ii) at least one polysaccharide, and optionally (iii) at least one glycol having 4 to 16 carbon atoms.

Use of an inducible extracellular vesicle as a medicament for skin, health care products or skin care products. A composition, comprising the inducible vesicle and the medicaments or care products for skin.

A cosmetic composition is provided including a brassica amidoalkyl compound which emits a malodor, a malodor suppressant which is Hydrogenated Castor Oil/Sebacic Acid Copolymer; and a cosmetically acceptable carrier.