Provided are nanoparticles including at least one Dead Sea Extract, as an active ingredient, and at least one amphipathic material. Further provided are skin-care compositions and/or pharmaceutical compositions including the nanoparticles. Cosmetic and/or therapeutic methods utilizing the nanoparticles are disclosed as well.

A method of lyophilizing exosomes using a cryoprotectant comprising methionine, mannitol and trehalose is disclosed. The lyophilized exosome product shows a good appearance which maintains a porous sponge shape without forming ice crystals. In addition, the lyophilized exosome product can be applied to a pharmaceutical composition, a skin external preparation and a cosmetic composition. For example, the lyophilized exosome product can be used as a solution obtained by simply mixing it with a diluent.

A method of lyophilizing exosomes using a cryoprotectant comprising methionine, mannitol and trehalose is disclosed. The lyophilized exosome product shows a good appearance which maintains a porous sponge shape without forming ice crystals. In addition, the lyophilized exosome product can be applied to a pharmaceutical composition, a skin external preparation and a cosmetic composition. For example, the lyophilized exosome product can be used as a solution obtained by simply mixing it with a diluent.

The invention concerns a pharmaceutical composition comprising a platelet lysate and its use to treat a wound, an anal fissure, vaginal atrophy or a wrinkle.

The invention concerns a pharmaceutical composition comprising a platelet lysate and its use to treat a wound, an anal fissure, vaginal atrophy or a wrinkle.

The present invention provides a patch for attaching to teeth or a surrounding part of teeth, and the patch can be easily removed by tooth brushing alone.

The present invention provides a patch for attaching to teeth or a surrounding part of teeth, and the patch can be easily removed by tooth brushing alone.

A multilayer nanofiber sheet (10) includes: a nanofiber layer (11) including nanofibers which comprise a water-soluble polymer compound; a substrate layer (12) arranged on one surface side of the nanofiber layer (11); and a water-insoluble porous layer (13) arranged on the other surface side of the nanofiber layer (11). The three layers are layered, and the multilayer nanofiber sheet is used in a state in which a surface thereof on the porous layer side is arranged so as to face a surface of an object. Preferably, the three layers are layered in a fixed state. Preferably, the porous layer (13) has a thickness of from 3 to 1000 μm.

A multilayer nanofiber sheet (10) includes: a nanofiber layer (11) including nanofibers which comprise a water-soluble polymer compound; a substrate layer (12) arranged on one surface side of the nanofiber layer (11); and a water-insoluble porous layer (13) arranged on the other surface side of the nanofiber layer (11). The three layers are layered, and the multilayer nanofiber sheet is used in a state in which a surface thereof on the porous layer side is arranged so as to face a surface of an object. Preferably, the three layers are layered in a fixed state. Preferably, the porous layer (13) has a thickness of from 3 to 1000 μm.

An insect repellent articles, such as tubular articles and patches, wherein an exemplary patch includes: a support film having a first major surface and a second major surface; a body-contacting pressure sensitive adhesive layer disposed on the first major surface; and a reservoir layer disposed on the second major surface, wherein the reservoir layer comprises an insect repellent incorporated within a polymeric carrier, and wherein the reservoir layer forms a non-contacting surface.