The present disclosure generally relates to aqueous compositions comprising a cannabinoid acid or a salt thereof, processes for the preparation thereof and uses thereof for inhalation.

The present invention discloses means and methods for enhancing cannabinoids efficacy. The invention relates to invigorating performance of cannabinoid by means of combining compounds to prime the binding cannabinoid receptors and promoting demethylation processes. Specifically, the present invention discloses a plant-based composition configured to enhance a physiological effect of a cannabis-derived compound, wherein said composition comprises a synergistic combination of the cannabis-derived compound, at least one portion of at least one plant comprising a methylating/demethylating active agent, and at least one portion of at least one enhancer plant.

Methods for identifying premature infants at risk for developing bronchopulmonary dysplasia and/or most likely to benefit from administration of inhaled nitric oxide for prevention of bronchopulmonary dysplasia (BPD). Methods for treating premature infants identified as at risk and/or likely to benefit are provided. also provided are methods for identifying premature infants that are not at risk for developing bronchopulmonary dysplasia and/or unlikely to benefit from administration of inhaled nitric oxide for prevention of bronchopulmonary dysplasia, and methods for avoiding risks of toxicity and undesirable side effects associated with inhaled nitric oxide therapy comprising administering only non-iNO treatment modalities to these infants.

Phyto material tablets, tablet vaporizers, methods and apparatus for forming phyto material tablets. The tablets are formed to increase vaporization efficiency. Tablets can include break regions to facilitate fracturing into multiple pieces for vaporization. The tablets can also include multiple layers of different phyto material mixtures. Compression molds are used to shape the tablets. The compression molds can be provided on a rotational assembly to facilitate rapid manufacturing of multiple tablets. The vaporizers include heating chambers that are configured to increase the surface area of the tablets exposed for vaporization. The heating chambers include compression or fracture members that compress and/or encourage fracturing of the tablets to assist vaporization.

The present invention is related to the use of HMGB1 antagonists, specifically derivatives of K883 in the treatment and/or prevention and/or inhibition of neuropathy pain, and in particular diabetic neuropathy in mammals, e.g., humans, and pharmaceutical compositions for the same comprising HMGB1 antagonists in an effective amount to treat and/or prevent and/or inhibit this condition.

The present invention relates to methods for treatment or prevention of asthma, mild intermittent asthma, mild persistent asthma, moderate persistent asthma, severe persistent asthma, eosinophilic asthma, neutrophilic asthma, steroid refractory asthma, status asthmaticus, pneumonia, bronchiectasis, COPD, sarcoidosis, and lung cancer based on reducing airway hyper responsiveness, increasing pulmonary compliance, reducing lung inflammation, reducing inflammatory cell count in bronchoalveolar fluid and reducing cytokine production by administration of a mammalian α- and/or β-defensin.

A microwave heating method and unit for heating an aerosol-forming sample due to microwave absorption by a material of the sample and in particular for thereby releasing by or from said sample upon heating said sample at least one aerosol, in particular in a or as a inhalation, vaporizer and/or smoking product or device, in particular for medical and/or pulmonary drug delivery applications. The microwave heating unit includes (i) a sample holding and exposing unit configured to receive and hold a sample in a holding and exposing space and to expose the sample to a microwave radiation field within said holding and exposing space, (ii) a microwave radiation generating and/or releasing unit configured to release the microwave radiation field to said holding and exposing space, and (iii) an impedance matching unit configured to achieve impedance matching between the holding and exposing space and the microwave radiation field.

Described are methods for reducing pulmonary resistance, reducing pulmonary pressure, and increasing pulmonary arterial compliance by providing a inhaled nitric oxide.

Disclosed are various methods and systems for increasing the permeability of cerebral capillaries. Increased permeability is accomplished via stretching means, inflaming means, overtaxing means, underoxygenating means, and/or immunocompromising means. Preferred stretching means include vasoconstrictors and cardiostimulators. Preferred inflaming means include electromagnetic fields and sonic waves. Preferred overtaxing means include xenon administration. Preferred underoxygenating means include airway-regulated oxygen deprivation. Preferred immunocompromising means include immunosuppressants and ionizing radiation. Also disclosed are processes for subsequently normalizing the permeability of cerebral capillaries. All disclosed means/processes can be selectively grouped, that is, combined or omitted, in accordance with the invention. By implementing the methods and systems invented, practitioners will be capable of opening (and closing) the blood-brain barrier, in which event therapeutic and diagnostic agents can enter the central nervous system and can act upon neurovascular-protected brain tissue.

The disclosure provides methods, formulations, and apparatus for making and using cannabinoid formulations.