An implantable delivery device and method for utilizing the device to delivery a bioactive agent to a subject in need thereof is described. The device includes a pattern of structures fabricated on a surface of the device to form a nanotopography. A random or non-random pattern of structures may be fabricated such as a complex pattern including structures of differing sizes and/or shapes. The device may be located adjacent tissue such as an endovascular implant or a perivascular implant, and may deliver the bioactive agent without triggering an immune or foreign body response to the bioactive agent.

This disclosure features methods and compositions for treating diseases of the gastrointestinal tract with a live biothcrapeutic.

A carrier device and methods of use are described. The device and methods are directed toward implanting in biological tissue and for releasing a medical payload or functional material in biological tissue according to a remote magnetic trigger. The carrier device has a cavity with an opening through an external surface of the device. The carrier device includes at least one moveable, magnetic element sensitive to a magnetic field gradient. When a magnetic field gradient, rotating magnetic field, or uniform magnetic field, or a combination of thereof is applied to the tissue, the moveable magnetic element provides release of the medical payload or functional material through the cavity opening. In some embodiments, payload release can be started, stopped, and restarted at a later time or place. In addition to payload release, devices of this invention are equipped with a propelling element, the propelling element is responsive to external stimuli that enables propulsion and navigation of the device.

Described herein in part are silanol based therapeutic payloads comprising a silanol terminus, a divalent spacer moiety, and a drug moiety capable of effecting a target cell or tissue.

Provided is a micro- and nano-fluidic chip, including at least one nanochannel array layer and at least one microchannel array layer that are alternately stacked. The at least one nanochannel array layer includes nanochannels, the at least one microchannel array layer includes input units and/or output units. The input unit includes inlet microchannel arrays and inlets, and the output unit includes outlet microchannel arrays and outlets. The inlet microchannel array includes inlet microchannels, the outlet microchannel array includes outlet microchannels, and the inlet microchannels and the outlet microchannels are connected through the nanochannels.

During nanoscale manufacture on a substrate, payload active agents are loaded on a delivery platform, with a release layer between the delivery platform and the payload active agent and an encapsulate over the payload active agent. The combined delivery platform, release layer, active agent payload, and encapsulant form a nanoscale drug delivery vehicle for subsequent delivery to a patient. The nanoscale drug delivery vehicle is small enough to permeate through the cell and deliver the payload active agent within the cell via reducing the retaining functionality of the release layer and degrading of the encapsulant. The nanoscale drug delivery vehicle offers a series of improved features including greater control of size, shape, dosage, bioavailability, cell targeting, and release timing.

This disclosure features methods and compositions for treating diseases of the gastrointestinal tract with a S1P modulator.

The presently disclosed subject matter describes the use of fluorinated elastomer-based materials, in particular perfluoropolyether (PFPE)-based materials, in high-resolution soft or imprint lithographic applications, such as micro- and nanoscale replica molding, and the first nano-contact molding of organic materials to generate high fidelity features using an elastomeric mold. Accordingly, the presently disclosed subject matter describes a method for producing free-standing, isolated nanostructures of any shape using soft or imprint lithography technique.

The present invention relates to a method of making a biocompatible micro-swimmer, the method comprising the steps of: providing a photo cross-linkable biopolymer solution; adding magnetic particles and a photo initiator to the photo cross-linkable biopolymer solution to form a 3D-printable solution; applying a laser with a variable focus directed at the 3D-printable solution; varying the focus of the laser through the 3D-printable solution to form the biocompatible micro-swimmer with a predefined shape; and applying a chemical linker to the biocompatible micro-swimmer having the pre-defined shape. The invention further relates to such a micro-swimmer and to a method of using such a micro-swimmer.

A microdevice containing a plurality of nanowires on a biocompatible surface, and methods of making and using the same are provided. Aspects of the present disclosure include forming a plurality of microdevices on a substrate where each microdevice includes a plurality of nanowires. The nanowires may be loaded with an active agent by disposing the active agent onto the surface of the nanowires. Also provided herein are kits that include the subject microdevices.