N-(furan-2-ylmethyl)-7H-purin-6-amine, or a pharmaceutically acceptable salt or solvate thereof, for prevention and/or treatment of circadian rhythm disorders, circadian rhythm diseases and/or circadian rhythm dysfunctions is disclosed. The disorders, diseases and dysfunctions include, inter alia, jet-lag, social jet-lag, shift-work disorder, and circadian rhythm disturbance induced by neurodegeneration is also disclosed.

The present invention provides a solid composition containing an amorphous poorly water-soluble material, and a method for producing the same. The solid composition of the present invention is a solid composition containing an amorphous poorly water-soluble material (1a), hydroxypropylmethyl cellulose (2), and one or more types of water-soluble polysaccharides (3) other than hydroxypropylmethyl cellulose, and is characterized in that an XRD analysis value of the solid composition is 4.0% or less.

The present invention provides a solid composition containing an amorphous poorly water-soluble material, and a method for producing the same. The solid composition of the present invention is a solid composition containing an amorphous poorly water-soluble material (1a), hydroxypropylmethyl cellulose (2), and one or more types of water-soluble polysaccharides (3) other than hydroxypropylmethyl cellulose, and is characterized in that an XRD analysis value of the solid composition is 4.0% or less.

The present disclosure is generally directed to a composition comprising a minicell and an active agent and to a bacterial minicell comprising an active agent. The compositions are suitable for improving animal health, increasing live stock production, or preventing animal-to-human transmission from both domestic animals and wildlife populations. Disclosed herein are methods of preparing a minicell encapsulating an active agent, delivering an active agent to a subject, and producing an animal feed and/or an animal vaccination for improving animal health and welfare.

The present disclosure is generally directed to a composition comprising a minicell and an active agent and to a bacterial minicell comprising an active agent. The compositions are suitable for improving animal health, increasing live stock production, or preventing animal-to-human transmission from both domestic animals and wildlife populations. Disclosed herein are methods of preparing a minicell encapsulating an active agent, delivering an active agent to a subject, and producing an animal feed and/or an animal vaccination for improving animal health and welfare.

The present disclosure relates to topical compositions and methods for the treatment of radiation dermatitis. The compositions include a cannabinoid and an oil comprising at least 1 wt % of at least one molecule containing an aliphatic chain with at least one cyclopropyl or cyclopropenyl group, such as a cyclopropene fatty acid or a cyclopropane fatty acid. The compositions can also include other components such as stabilizers, thinners, thickeners, fragrances, moisturizers, emollients; and components that provide anti-irritation or anti-inflammatory properties to the compositions.

The present disclosure relates to topical compositions and methods for the treatment of radiation dermatitis. The compositions include a cannabinoid and an oil comprising at least 1 wt % of at least one molecule containing an aliphatic chain with at least one cyclopropyl or cyclopropenyl group, such as a cyclopropene fatty acid or a cyclopropane fatty acid. The compositions can also include other components such as stabilizers, thinners, thickeners, fragrances, moisturizers, emollients; and components that provide anti-irritation or anti-inflammatory properties to the compositions.

Compositions promote restful sleep and/or to a feeling of restful sleep. Specifically, the compositions of the present invention comprise a combination of hops extract, magnolia bark extract, melatonin, magnesium, rhodiola extract, L-theanine, vitamin B6, and spearmint extract and/or green tea extract to promote restful sleep and/or a feeling of restful sleep in an individual or animal. Methods of making and using the same are further provided.

Compositions promote restful sleep and/or to a feeling of restful sleep. Specifically, the compositions of the present invention comprise a combination of hops extract, magnolia bark extract, melatonin, magnesium, rhodiola extract, L-theanine, vitamin B6, and spearmint extract and/or green tea extract to promote restful sleep and/or a feeling of restful sleep in an individual or animal. Methods of making and using the same are further provided.

Compositions promote restful sleep and/or to a feeling of restful sleep. Specifically, the compositions of the present invention comprise a combination of hops extract, magnolia bark extract, melatonin, magnesium, rhodiola extract, L-theanine, vitamin B6, and spearmint extract and/or green tea extract to promote restful sleep and/or a feeling of restful sleep in an individual or animal. Methods of making and using the same are further provided.