Compounds having a structure of formula (I), (I-A), (Ia)-(Ie), (A)-(E), and (II) or a pharmaceutically acceptable salt, tautomer or stereoisomer thereof are provided. Uses of such compounds for modulating androgen receptor activity, imaging diagnostics in cancer and therapeutics, and methods for treatment of disorders including prostate cancer are also provided.

Provided are a novel amorphous curcumin compound powdery composition that is inexpensive, is improved in bioabsorbability and bioavailability of curcumin, and has long-term stability, and a method for producing the powdery composition.

The present invention relates to a powdery composition containing an amorphous curcumin compound and a hydrophilic modified starch and having a Raman spectrum including one or more peaks at wavenumbers of 1630, 1599, 1428, and 1243 (expressed in ±2 cm.sup.−1) and a method for producing the powdery composition.

Provided are a novel amorphous curcumin compound powdery composition that is inexpensive, is improved in bioabsorbability and bioavailability of curcumin, and has long-term stability, and a method for producing the powdery composition.

The present invention relates to a powdery composition containing an amorphous curcumin compound and a hydrophilic modified starch and having a Raman spectrum including one or more peaks at wavenumbers of 1630, 1599, 1428, and 1243 (expressed in ±2 cm.sup.−1) and a method for producing the powdery composition.

Methods of quantifying a N.sup.2-(1-carboxyethyl)-2′-deoxyguanosine (CEdG) levels in biological samples and comparing those levels to known normal levels can diagnose a number of metabolic disorders or complications associated therewith, including diabetes, its associated complications, and cancer. Methods can also determine whether therapies for disorders are effective by measuring CEdG levels before and after treatment. Measurement of CEdG levels is achieved by using liquid chromatography electrospray ionization tandem mass spectrometry.

The use of Manuka Honey in the production of a medicament for treating a virus by applying the honey, via the medicament, to the periphery of tissue on which the virus is present. Further, The use of one or more of methylglyoxal; 3-phenyllactic acid; p-coumaric acid; quercetin; pinocembrin; pinobanksin; hesperidin; galangin; kaempferol; chrysin; and luteolin in the preparation of an antiviral medicament for administering to a patient to treat, or prevent, infection by the virus. Further, a respiratory mask comprising a barrier permeable to air, the barrier having sufficient Manuka Honey for substantially disinfecting a vims in air when breathed in or otherwise passed through the barrier while the mask is worn.

The use of Manuka Honey in the production of a medicament for treating a virus by applying the honey, via the medicament, to the periphery of tissue on which the virus is present. Further, The use of one or more of methylglyoxal; 3-phenyllactic acid; p-coumaric acid; quercetin; pinocembrin; pinobanksin; hesperidin; galangin; kaempferol; chrysin; and luteolin in the preparation of an antiviral medicament for administering to a patient to treat, or prevent, infection by the virus. Further, a respiratory mask comprising a barrier permeable to air, the barrier having sufficient Manuka Honey for substantially disinfecting a vims in air when breathed in or otherwise passed through the barrier while the mask is worn.

A system for industrial application package management includes a computing device having a processor and a memory having executable programs and applications stored thereon, including plurality of industrial application programs miming an engineering project involving multiple different disciplines, and a package manager client. The package manager client communicates with a remote repository server that hosts application packages, and sends requests for packages and receives package deliveries. The package manager client unbundles package metainformation relevant to a domain specific application and according to an industrial package information schema. A dependency tracking module identifies dependencies of a current package to other packages and generates a dependency tree that includes the name and version of each dependent package. An upgrade analyzer compares dependency trees to identify dependency incompatibilities as conflicting packages based on inconsistencies and performs an automated resolution of the dependency incompatibilities.

A system for industrial application package management includes a computing device having a processor and a memory having executable programs and applications stored thereon, including plurality of industrial application programs miming an engineering project involving multiple different disciplines, and a package manager client. The package manager client communicates with a remote repository server that hosts application packages, and sends requests for packages and receives package deliveries. The package manager client unbundles package metainformation relevant to a domain specific application and according to an industrial package information schema. A dependency tracking module identifies dependencies of a current package to other packages and generates a dependency tree that includes the name and version of each dependent package. An upgrade analyzer compares dependency trees to identify dependency incompatibilities as conflicting packages based on inconsistencies and performs an automated resolution of the dependency incompatibilities.

A transdermal formulation for the delivery of a nitric oxide booster or nitric oxide precursor to a subject is provided. The formulation can be applied to the treatment of various diseases or conditions by enhancing systemic level of nitric oxide.

A transdermal formulation for the delivery of a nitric oxide booster or nitric oxide precursor to a subject is provided. The formulation can be applied to the treatment of various diseases or conditions by enhancing systemic level of nitric oxide.