The present disclosure is concerned with liposomal formulations comprising troponoid compounds and methods of using same in the treatment of, for example, viral infections, antimicrobial infections, cancer, inflammatory diseases, and cardiovascular diseases. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.

The present disclosure provides, inter alia, compositions and methods for treating or ameliorating the effects of a tumor in a subject comprising a three-dimensional (3D) organoid system.

The present disclosure provides, inter alia, compositions and methods for treating or ameliorating the effects of a tumor in a subject comprising a three-dimensional (3D) organoid system.

The present invention concerns a pharmaceutically acceptable salt of a compound of the following formula (I): H.sub.2N—CH(R.sub.1)—CH.sub.2S—S—CH.sub.2—CH(R.sub.2—CONH—CH(R.sub.3)—COOR.sub.4 (I) and more particularly an acid addition salt thereof, and the compositions comprising the same, for use in the prevention or treatment of trigeminal nerve pain, in particular migraines or trigeminal neuralgia.

The present invention concerns a pharmaceutically acceptable salt of a compound of the following formula (I): H.sub.2N—CH(R.sub.1)—CH.sub.2S—S—CH.sub.2—CH(R.sub.2—CONH—CH(R.sub.3)—COOR.sub.4 (I) and more particularly an acid addition salt thereof, and the compositions comprising the same, for use in the prevention or treatment of trigeminal nerve pain, in particular migraines or trigeminal neuralgia.

Provided are novel prodrugs of treprostinil, as well as methods of making and methods of using these prodrugs.

Provided are novel prodrugs of treprostinil, as well as methods of making and methods of using these prodrugs.

The present invention relates to novel aminoesters compounds or its pharmaceutically acceptable salts or optical isomers, racemates, diastereoisomers, enantiomers or tautomers. The present invention also relates to their process of preparation and to these compounds for use as a medicament, in particular for the treatment or the prevention of cancer. The present invention further relates to an antibody drug conjugate comprising such compounds.

The present invention relates to novel aminoesters compounds or its pharmaceutically acceptable salts or optical isomers, racemates, diastereoisomers, enantiomers or tautomers. The present invention also relates to their process of preparation and to these compounds for use as a medicament, in particular for the treatment or the prevention of cancer. The present invention further relates to an antibody drug conjugate comprising such compounds.

The present invention relates to a hygroscopic matrix based composition, a process for the preparation thereof and its use in the treatment of diseases.