The present disclosure provides methods, substrates and compositions for modifying, repairing, and/or engineering blood vessel tissue, and in particular the use of such compositions for treating a diseased blood vessel.

The present disclosure provides methods, substrates and compositions for modifying, repairing, and/or engineering blood vessel tissue, and in particular the use of such compositions for treating a diseased blood vessel.

Embodiments of the present invention replace at least some of the flame resistant fibers traditionally used in the batting of a thermal liner (e.g., aramids) with thermally stable polyamide fibers (e.g., nylon fibers). The TPP performance of garments incorporating embodiments of thermal liners contemplated herein is comparable toif not improved overgarments formed with traditional thermal liners.

Embodiments of the present invention replace at least some of the flame resistant fibers traditionally used in the batting of a thermal liner (e.g., aramids) with thermally stable polyamide fibers (e.g., nylon fibers). The TPP performance of garments incorporating embodiments of thermal liners contemplated herein is comparable toif not improved overgarments formed with traditional thermal liners.

The present disclosure discloses reinforced electrospun fibrous membranes and preparation methods therefor. The reinforced electrospun fibrous membranes can include an electrospun fibrous membrane body and a plurality of reinforcing thread sets fixed to the electrospun fibrous membrane body through holes thereon, wherein any two of the plurality of reinforcing thread sets are parallel to each other; each of the reinforcing thread sets comprises a starting end and a terminal end, both being connected to an edge of the electrospun fibrous membrane body; each of the reinforcing thread sets comprises at least one reinforcing fibrous thread consisting of a main thread and an auxiliary thread respectively arranged at a front side and a bottom side of the electrospun fibrous membrane body and configured to interlace each other at the through hole. By providing reinforcing thread sets on the electrospun fibrous membrane body to impart the electrospun fibrous membrane with a greater mechanical property, the mechanical strength required for the movement of the tissue is ensured, and the electrospun fibrous membrane is easy to be folded or rolled into other shapes. The electrospun fibrous membrane body may be made of degradable materials, which are gradually degraded and absorbed in the process of inducing new tissue formation, thereby providing space for the formation of new tissues.

The present invention provides compositions comprising aligned fibers of electrospun PNIPAAm and poly (-caprolactone) (PCL) (denoted PNIPAAm/PCL fibers). The PNIPAAm/PCL compositions enable enhanced growth and detachment of intact anisotropic cell sheets. The compositions do not require chemical modification or resource-intensive techniques, thus saving time and expense, and have the potential to generate tissue-specific, aligned cell sheets for transplant studies.

The present invention provides compositions comprising aligned fibers of electrospun PNIPAAm and poly (-caprolactone) (PCL) (denoted PNIPAAm/PCL fibers). The PNIPAAm/PCL compositions enable enhanced growth and detachment of intact anisotropic cell sheets. The compositions do not require chemical modification or resource-intensive techniques, thus saving time and expense, and have the potential to generate tissue-specific, aligned cell sheets for transplant studies.

A method for laying down a nanoweb of nanofibers from a centrifugal spinning process by a combination of an air flow field and a charging arrangement. Fibrous streams in the form of fibrils of molten polymer or polymer solution are discharged from a rotating member into an air flow field that is essentially parallel to the direction of discharge of fibrils at the point of discharge of the fibrils. The fibrous streams are attentuated and directed by means of the air flow field onto the surface of a collector to form a nanoweb. The fibrous streams are charged along all or at least a portion of their route from the point of discharge to the surface of the collector.

A method for laying down a nanoweb of nanofibers from a centrifugal spinning process by a combination of an air flow field and a charging arrangement. Fibrous streams in the form of fibrils of molten polymer or polymer solution are discharged from a rotating member into an air flow field that is essentially parallel to the direction of discharge of fibrils at the point of discharge of the fibrils. The fibrous streams are attentuated and directed by means of the air flow field onto the surface of a collector to form a nanoweb. The fibrous streams are charged along all or at least a portion of their route from the point of discharge to the surface of the collector.

The disclosure relates to nonwoven fabric including a nonwoven material having a first surface and an opposing second surface, wherein the first surface has a first average surface charge and the second surface has a second average surface charge, the first average surface charge being different from the second average surface charge, wherein the nonwoven material includes a first plurality of fibers including a first polymer and a second plurality of fibers including a second polymer different from the first polymer. A method for imparting surface charge to a nonwoven N61824_1570Wabric is also provided.