The present invention relates to an eye-drop composition comprising 2-amino-9-[[(1S,2R)-1,2-bis(hydroxymethyl)cyclopropyl]methyl]-1,9-dihydro-6H-Purin-6-one, and the use thereof for the diagnosis and treatment of herpetic eye infections in companion animals.

The present disclosure provides compounds useful as inhibitors of SARM1 NADase activity, compositions thereof, and methods of using the same. The present disclosure provides compounds useful for treating a neurodegenerative or neurological disease or disorder, compositions thereof, and methods of using the same.

The present invention relates to an eye-drop composition comprising 2-amino-9-[[(1S,2R)-1,2-bis(hydroxymethyl)cyclopropyl]methyl]-1,9-dihydro-6H-Purin-6-one, and the use thereof for the diagnosis and treatment of herpetic eye infections in companion animals.

The present invention relates to an eye-drop composition comprising 2-amino-9-[[(1S,2R)-1,2-bis(hydroxymethyl)cyclopropyl]methyl]-1,9-dihydro-6H-Purin-6-one, and the use thereof for the diagnosis and treatment of herpetic eye infections in companion animals.

The present invention relates to the use of one or more compounds selected from the following classes of biologically active agents: an a-adrenergic antagonist, an anthelmintic agent, an antifungal agent, an antimalarial agent, an antineoplastic agent, an antipsychotic agent, an antioxidant, a vasodilator and/or a vitamin, or a pharmaceutically acceptable derivative thereof, for use in the treatment of a microbial infection and in particular for killing multiplying, non-multiplying and/or clinically latent microorganisms associated with such an infection.

The present invention relates to the use of one or more compounds selected from the following classes of biologically active agents: an a-adrenergic antagonist, an anthelmintic agent, an antifungal agent, an antimalarial agent, an antineoplastic agent, an antipsychotic agent, an antioxidant, a vasodilator and/or a vitamin, or a pharmaceutically acceptable derivative thereof, for use in the treatment of a microbial infection and in particular for killing multiplying, non-multiplying and/or clinically latent microorganisms associated with such an infection.

The present disclosure provides compounds useful as inhibitors of SARM1 NADase activity, compositions thereof, and methods of using the same. The present disclosure provides compounds useful for treating a neurodegenerative or neurological disease or disorder, compositions thereof, and methods of using the same.

Disclosed herein are methods of treating a malignant adrenocortical tumor, including a locally advanced and metastatic adrenocortical carcinoma. In some examples, methods of treating a malignant adrenocortical tumor include administering an effective amount of niclosamide alone or in combination with other therapeutic agents to a subject in need thereof, thereby treating the malignant adrenocortical tumor.

Disclosed herein are methods of treating a malignant adrenocortical tumor, including a locally advanced and metastatic adrenocortical carcinoma. In some examples, methods of treating a malignant adrenocortical tumor include administering an effective amount of niclosamide alone or in combination with other therapeutic agents to a subject in need thereof, thereby treating the malignant adrenocortical tumor.

Disclosed herein are methods of treating a malignant adrenocortical tumor, including a locally advanced and metastatic adrenocortical carcinoma. In some examples, methods of treating a malignant adrenocortical tumor include administering an effective amount of niclosamide alone or in combination with other therapeutic agents to a subject in need thereof, thereby treating the malignant adrenocortical tumor.