The present invention relates to a formulation comprising blends of formulations (or colloidal dispersions) and its topical application. The formulation comprises at least two different types of colloidal dispersion comprising deformable colloidal particles, wherein the deformable colloidal particles comprise a non-ionic surfactant and/or a phospholipid. The deformable colloidal particles of the invention may comprise an agent of interest (AOI) or may be free of an AOI. The formulation may comprise an AOI that is not associated with the deformable colloidal particles. The present invention also includes kits comprising the formulation of the present invention and the use of the formulation in medicine, skin care and cosmetics.

The present invention relates to a formulation comprising blends of formulations (or colloidal dispersions) and its topical application. The formulation comprises at least two different types of colloidal dispersion comprising deformable colloidal particles, wherein the deformable colloidal particles comprise a non-ionic surfactant and/or a phospholipid. The deformable colloidal particles of the invention may comprise an agent of interest (AOI) or may be free of an AOI. The formulation may comprise an AOI that is not associated with the deformable colloidal particles. The present invention also includes kits comprising the formulation of the present invention and the use of the formulation in medicine, skin care and cosmetics.

The present invention relates to compositions comprising a colloidal dispersion and an Agent of Interest (AOI), wherein the colloidal dispersion comprises deformable colloidal particles and wherein the AOI is not associated with the deformable colloidal particles. The present invention also provides kits and transdermal drug release devices comprising the compositions of the present invention, and the use of these compositions in medicine, skin care and cosmetics.

The present invention relates to compositions comprising a colloidal dispersion and an Agent of Interest (AOI), wherein the colloidal dispersion comprises deformable colloidal particles and wherein the AOI is not associated with the deformable colloidal particles. The present invention also provides kits and transdermal drug release devices comprising the compositions of the present invention, and the use of these compositions in medicine, skin care and cosmetics.

The present invention relates to compositions comprising a colloidal dispersion and an Agent of Interest (AOI), wherein the colloidal dispersion comprises deformable colloidal particles and wherein the AOI is not associated with the deformable colloidal particles. The present invention also provides kits and transdermal drug release devices comprising the compositions of the present invention, and the use of these compositions in medicine, skin care and cosmetics.

Fragrance compositions comprising one or more fragrance compounds for use in increasing the duration of sleep and/or improving quality of sleep in a subject is disclosed. Fragrance compositions comprising one or more fragrance compounds for use in increasing the quality of sleep in a subject (i.e., an increase in the time the subject is asleep during the night, a decrease in the time the subject is awake during the night, an increase in the time the subject experiences REM sleep, an increase in the time the subject experiences deep sleep, an increase in the time the subject experiences light sleep; and an increase in overall sleep efficiency) is disclosed. The composition can be incorporated into various consumer end products.

Fragrance compositions comprising one or more fragrance compounds for use in increasing the duration of sleep and/or improving quality of sleep in a subject is disclosed. Fragrance compositions comprising one or more fragrance compounds for use in increasing the quality of sleep in a subject (i.e., an increase in the time the subject is asleep during the night, a decrease in the time the subject is awake during the night, an increase in the time the subject experiences REM sleep, an increase in the time the subject experiences deep sleep, an increase in the time the subject experiences light sleep; and an increase in overall sleep efficiency) is disclosed. The composition can be incorporated into various consumer end products.

A comfort article may comprise a proximal layer that adheres to the skin of a foot, and a non-slip distal layer with a high coefficient of friction that prevents footwear from sliding with respect to the foot without adhering to or sticking to the shoe. The proximal layer comprises a sticky adhesive surface or dry adhesive. The comfort article is cutout into various shapes and applied to one or more locations on a user's foot at a point of contact within the shoe that is intended to prevent the foot from moving with respect to the shoe. The comfort articles may also be supplied as a kit with various precut devices configured to fit certain types of footwear and accommodate user preferences. A cushion layer(s) may be interposed between the proximal layer and distal layer.

A comfort article may comprise a proximal layer that adheres to the skin of a foot, and a non-slip distal layer with a high coefficient of friction that prevents footwear from sliding with respect to the foot without adhering to or sticking to the shoe. The proximal layer comprises a sticky adhesive surface or dry adhesive. The comfort article is cutout into various shapes and applied to one or more locations on a user's foot at a point of contact within the shoe that is intended to prevent the foot from moving with respect to the shoe. The comfort articles may also be supplied as a kit with various precut devices configured to fit certain types of footwear and accommodate user preferences. A cushion layer(s) may be interposed between the proximal layer and distal layer.

The present invention is directed to nanosuspensions of salsalate and methods of making and using such compositions.