The present invention is directed to novel cyclic amines which inhibit the P2X7 receptor.

The present disclosure is directed to novel methods of treating type-1 or type-2 diabetes by inactivating TLR2 and TLR4 genes together in cells capable of producing insulin and/or regenerating cells, and providing the cells to a subject in need thereof.

The present disclosure is directed to novel methods of treating type-1 or type-2 diabetes by inactivating TLR2 and TLR4 genes together in cells capable of producing insulin and/or regenerating cells, and providing the cells to a subject in need thereof.

The present invention provides a new combinatorial drug or a new pharmaceutical composition comprising nitazoxanide, atovaquone and/or ribavirin, and their use for the treatment or prevention of coronavirus infections, particularly the use for the treatment or prevention of infections caused by SARS-CoV-2 and mutants thereof.

The present invention provides a new combinatorial drug or a new pharmaceutical composition comprising nitazoxanide, atovaquone and/or ribavirin, and their use for the treatment or prevention of coronavirus infections, particularly the use for the treatment or prevention of infections caused by SARS-CoV-2 and mutants thereof.

The present disclosure relates to methods of treatment for various diseases, including chronic obstructive pulmonary disease, involving administration of compositions comprising membrane-enclosed vesicles. The membrane-enclosed vesicles may be derived from a stem cell such as a mesenchymal stem cell.

The present disclosure relates to methods of treatment for various diseases, including chronic obstructive pulmonary disease, involving administration of compositions comprising membrane-enclosed vesicles. The membrane-enclosed vesicles may be derived from a stem cell such as a mesenchymal stem cell.

The present invention relates to compositions and uses of novel high penetration compositions or high penetration prodrugs (HPP), in particular HPPs for non-steroidal anti-inflammatory agents (NSAIAs), which are capable of crossing biological barriers with high penetration efficiency. The HPPs herein are capable of being converted to parent active drugs or drug metabolites after crossing the biological barrier and thus can render treatments for the conditions that the parent drugs or metabolites can. Additionally, due to the ability of penetrating biological barriers, the HPPs herein are capable of reaching areas that parent drugs may not be able to access or to render a sufficient concentration at the target areas and therefore render novel treatments. The HPPs herein can be administered to a subject through various administration routes. For example, the HPPs can be locally delivered to an action site of a condition with a high concentration due to their ability of penetrating biological barriers and thus obviate the need for a systematic administration. For another example, the HPPs herein can be systematically administer to a biological subject and enter the general circulation with a faster rate.

The present invention is directed to novel cyclic amines which inhibit the P2X7 receptor.

A method of reducing cellular damage to a plant by treating the plant with a compound containing an NO-releasing moiety and an H.sub.2S-releasing moiety covalently bonded to an aspirin derived core or a NOSH compound is claimed. The compounds may also be used in a method of priming a plant against abiotic stress factors and a method of promoting plant growth.