Provided herein are porphyrinato-lanthanide complexes useful as theranostic agents and methods of preparation and use thereof. The porphyrinato-lanthanide complexes are useful in the treatment and imaging of cancer.

The invention concerns a mixture or a composition, that is preferably therapeutically active by topical administration, comprising:at least one metal salt, the metal being chosen from molybdenum (Mo), tungsten (W), vanadium (V), gold (Au), a lanthanide, in particular lanthanum; at least one chelating agent; at least one source of peroxidative radicals; at least one buffer agent; and pharmaceutical compositions constituted by or comprising said mixture, the methods for producing same and applications thereof, in particular in a method for the therapeutic treatment of a viral infection, and in particular involving a virus of the Herpesviridae family; or as an anti-inflammatory.

The invention concerns a mixture or a composition, that is preferably therapeutically active by topical administration, comprising:at least one metal salt, the metal being chosen from molybdenum (Mo), tungsten (W), vanadium (V), gold (Au), a lanthanide, in particular lanthanum; at least one chelating agent; at least one source of peroxidative radicals; at least one buffer agent; and pharmaceutical compositions constituted by or comprising said mixture, the methods for producing same and applications thereof, in particular in a method for the therapeutic treatment of a viral infection, and in particular involving a virus of the Herpesviridae family; or as an anti-inflammatory.

A cerium oxide nanoparticle is produced by mixing a solution of an aromatic heterocyclic compound having no substituent or at least one substituent selected from the group consisting of a methyl group, an ethyl group, an amino group, an aminomethyl group, a monomethylamino group, a dimethylamino group, and a cyano group and containing 2 to 8 carbon atoms and 1 to 4 nitrogen atoms in a ring structure of the aromatic heterocyclic compound, with a solution containing a cerium (III) ion or with a cerium (III) salt, followed by addition of an oxidant.

A cerium oxide nanocomplex, a composition containing the cerium oxide nanocomplex as an active ingredient, and uses thereof for preventing or treating peritonitis are disclosed. The cerium oxide nanocomplex improves the biomedical stability, biocompatibility, and efficiency of the production process of nanoparticles while maintaining the excellent inhibitory activity against inflammation by applying a biocompatible polymer composed of an optimal combination. The cerium oxide nanocomplex may be used as an excellent therapeutic composition that may greatly improve patients' survival rate by effectively inhibiting inflammatory response and quickly blocking tissue damage at early stage of peritonitis when a radical inflammatory injury occurs because of the penetration of bacteria, foreign body and immune cells into a perforated organ in the abdominal cavity.

The present invention provides: nanoparticles including a compound that includes porous silica and at least one high-atom selected from the group consisting of gadolinium atoms, iodine atoms, gold atoms, silver atoms, and platinum atoms; and a pharmaceutical composition for radiation treatment, useful for treatment of solid tumors, etc., and including these nanoparticles and a pharmaceutically acceptable carrier.

Disclosed is a composition comprising iron oxide magnetic particles. The composition is delivered to a liver in a hepatocyte-specific manner to minimize damage to other organs, and is safely excreted from a body within a few weeks. Further, the particles have excellent hepatocyte targeting ability, and thus are used as a liver cancer treatment agent and a hepatocyte targeting carrier.

The present invention relates to the field of fullerene application, and in particular to an application of fullerene and a derivative thereof in regulating intestinal flora. The fullerene and the derivative thereof may increase beneficial bacteria, decrease harmful bacteria and increase the abundance of intestinal flora when used for regulating intestinal flora, which is thus capable of relieving or treating human diseases (including gastrointestinal diseases, neurodegenerative diseases, metabolic diseases, sleep disorders, inflammation, tumors) and enhancing human immunity, improving animal physiques, regulating animal intestinal tracts, preventing or treating animal diseases, or promoting animal growth with great application prospect.

A cerium oxide nanocomplex, a method for preparing the cerium oxide nanocomplex, a composition containing the cerium oxide nanocomplex as an active ingredient, and a method for preventing or treating inflammatory or autoimmune diseases. The composition may be used as an efficient nanoparticle therapeutic composition by applying a biocompatible dispersion stabilizer composed of an optimal combination to significantly improve the biomedical stability, biocompatibility, and efficiency of the production process of nanoparticles while maintaining the intrinsic pharmacological effect of the nanoparticles.

A cerium oxide nanocomplex, a method for preparing the cerium oxide nanocomplex, a composition containing the cerium oxide nanocomplex as an active ingredient, and a method for preventing or treating inflammatory or autoimmune diseases. The composition may be used as an efficient nanoparticle therapeutic composition by applying a biocompatible dispersion stabilizer composed of an optimal combination to significantly improve the biomedical stability, biocompatibility, and efficiency of the production process of nanoparticles while maintaining the intrinsic pharmacological effect of the nanoparticles.