Patent classifications
A61K33/36
HIV-CURE
The embodiments use an innovative approach with the goal of permanent eradication of the virus. Instead of using drugs that block different stages of the virus life cycle (which have failed to induce a permanent cure), or approaches attempting to track infected cells, the embodiments use small virucidal molecules that are known to destroy the virus in vitro and that can easily penetrate all human cells, including memory cells or other reservoir cells. The problem with the use of small molecules is their toxicity to humans or animals when administered in doses sufficient to achieve intracellular concentrations high enough to destroy the virus in all forms. The embodiments overcome these toxicities (especially the comatose state) by using a 24-hour treatment with general anesthesia, endotracheal intubation with hemodynamic support, and controlled monitored ventilation; also, a combination of these molecules are used which decreases toxicity but has additive virucidal effects.
Arsenic compositions
The present invention is predicated on the realisation that problems with the poor water solubility of arsenic trioxide and the extreme difficulty in dissolving arsenic trioxide in anything other than a very basic solution, could be overcome by forming a much more soluble diarsenic tetraoxide, including the compound NaHAs.sub.2O.sub.4, prior to its delivery to a patient. Pharmaceutical compositions with such compounds and their use in the treatment of cancers is disclosed.
Arsenic compositions
The present invention is predicated on the realisation that problems with the poor water solubility of arsenic trioxide and the extreme difficulty in dissolving arsenic trioxide in anything other than a very basic solution, could be overcome by forming a much more soluble diarsenic tetraoxide, including the compound NaHAs.sub.2O.sub.4, prior to its delivery to a patient. Pharmaceutical compositions with such compounds and their use in the treatment of cancers is disclosed.
Xenon and/or argon treatment as an adjunct to psychotherapy for psychiatric disorders
The present invention relates generally to the fields of treating psychiatric disorders, in particular, anxiety disorders including post-traumatic stress disorder (PTSD) in subjects, e.g., human subjects, by administering a xenon and/or argon containing composition. Treatments can also employ psychotherapy in combination with administration of xenon and/or argon, alone or in combination with additional psychotherapeutic medications to treat the anxiety disorder and reduce a symptom of the anxiety disorder in the subject.
Xenon and/or argon treatment as an adjunct to psychotherapy for psychiatric disorders
The present invention relates generally to the fields of treating psychiatric disorders, in particular, anxiety disorders including post-traumatic stress disorder (PTSD) in subjects, e.g., human subjects, by administering a xenon and/or argon containing composition. Treatments can also employ psychotherapy in combination with administration of xenon and/or argon, alone or in combination with additional psychotherapeutic medications to treat the anxiety disorder and reduce a symptom of the anxiety disorder in the subject.
Xenon and/or argon treatment as an adjunct to psychotherapy for psychiatric disorders
The present invention relates generally to the fields of treating psychiatric disorders, in particular, anxiety disorders including post-traumatic stress disorder (PTSD) in subjects, e.g., human subjects, by administering a xenon and/or argon containing composition. Treatments can also employ psychotherapy in combination with administration of xenon and/or argon, alone or in combination with additional psychotherapeutic medications to treat the anxiety disorder and reduce a symptom of the anxiety disorder in the subject.
Isotonic crystalloid aqueous solution
The invention relates to an isotonic crystalloid aqueous solution of the type containing Na.sup.+, K.sup.+ and Cl.sup.−, and to the use thereof as a vasodilator.
Isotonic crystalloid aqueous solution
The invention relates to an isotonic crystalloid aqueous solution of the type containing Na.sup.+, K.sup.+ and Cl.sup.−, and to the use thereof as a vasodilator.
ANTI-CANCER EFFECTS OF PROTEASOME INHIBITORS IN COMBINATION WITH GLUCOCORTICOIDS, ARSENIC CONTAINING COMPOUNDS, AND ASCORBIC ACID
The present invention provides methods of treatment for hematological malignancies involving synergistic combination of a proteasome inhibitor, a glucocorticoid, an arsenic-containing compound, and ascorbic acid or a derivative thereof provide an unexpected efficacy in the treatment for hematological disorders. The hematological disorders treated by the current invention include multiple myeloma, and may also include hematological disorders that are refractory to prior cancer treatments, or relapsed hematologic disorders.
ANTI-CANCER EFFECTS OF PROTEASOME INHIBITORS IN COMBINATION WITH GLUCOCORTICOIDS, ARSENIC CONTAINING COMPOUNDS, AND ASCORBIC ACID
The present invention provides methods of treatment for hematological malignancies involving synergistic combination of a proteasome inhibitor, a glucocorticoid, an arsenic-containing compound, and ascorbic acid or a derivative thereof provide an unexpected efficacy in the treatment for hematological disorders. The hematological disorders treated by the current invention include multiple myeloma, and may also include hematological disorders that are refractory to prior cancer treatments, or relapsed hematologic disorders.