The purpose of the present invention is to provide a chondrocyte culture with high tissue regeneration ability. This purpose is met by a method involving a step in which a cell population separated from cartilage tissue is cultured on a thermoreversible polymer.

The purpose of the present invention is to provide a chondrocyte culture with high tissue regeneration ability. This purpose is met by a method involving a step in which a cell population separated from cartilage tissue is cultured on a thermoreversible polymer.

To provide a pharmaceutical composition having a novel use comprising a dental pulp-derived multipotent stem cell preparation that can be administered to humans. A pharmaceutical composition comprising dental pulp-derived stem cells as an active ingredient for suppressing infiltration into a tissue of at lease neutrophils, monocytes, or lymphocytes.

To provide a pharmaceutical composition having a novel use comprising a dental pulp-derived multipotent stem cell preparation that can be administered to humans. A pharmaceutical composition comprising dental pulp-derived stem cells as an active ingredient for suppressing infiltration into a tissue of at lease neutrophils, monocytes, or lymphocytes.

The present invention relates to a pharmaceutical composition for preventing or treating obesity or non-alcoholic fatty liver, containing dental tissue-derived mesenchymal stem cells cryopreserved by vitrification. The pharmaceutical composition for preventing or treating obesity or non-alcoholic fatty liver, of the present invention, reduces body weight, lowers serum adipokine concentration, allows the liver to recover in view of histological findings, and improves lipid metabolic enzymes in the liver, thereby exhibiting remarkable prevention and treatment effects on obesity or non-alcoholic fatty liver. In addition, dental tissue-derived mesenchymal stem cells, which are the active ingredients of the present invention, are mesodermal stem cells having verified safety and may be obtained with the least invasiveness, and thus are expected to be effectively used as a cell therapeutic agent for obesity or non-alcoholic fatty liver.

The present invention relates to a pharmaceutical composition for preventing or treating obesity or non-alcoholic fatty liver, containing dental tissue-derived mesenchymal stem cells cryopreserved by vitrification. The pharmaceutical composition for preventing or treating obesity or non-alcoholic fatty liver, of the present invention, reduces body weight, lowers serum adipokine concentration, allows the liver to recover in view of histological findings, and improves lipid metabolic enzymes in the liver, thereby exhibiting remarkable prevention and treatment effects on obesity or non-alcoholic fatty liver. In addition, dental tissue-derived mesenchymal stem cells, which are the active ingredients of the present invention, are mesodermal stem cells having verified safety and may be obtained with the least invasiveness, and thus are expected to be effectively used as a cell therapeutic agent for obesity or non-alcoholic fatty liver.

An application of a traditional Chinese medicine composition in preparing a medicine for treating or preventing coronavirus infection. The traditional Chinese medicine composition is characterized by being prepared from the following raw materials in parts by weight: 5-15 parts of Cornu saigae tataricae or 50-150 parts of goral horns, 10-60 parts of Bulbus Fritillariae Ussuriensis, 15-60 parts of Radix et Rhizoma Rhei, 7-30 parts of Radix scutellariae, 7-30 parts of Lapis Chloriti, 10-50 parts of gypsum fibrosum, 5-20 parts of calculus bovis artifactus, and 15-60 parts of radix glycyrrhizae. The traditional Chinese medicine composition can inhibit 2019-nCoV replication in cells, so that cells infected by 2019-nCoV viruses have no lesion. Therefore, the traditional Chinese medicine composition can treat or prevent coronavirus related diseases.

An application of a traditional Chinese medicine composition in preparing a medicine for treating or preventing coronavirus infection. The traditional Chinese medicine composition is characterized by being prepared from the following raw materials in parts by weight: 5-15 parts of Cornu saigae tataricae or 50-150 parts of goral horns, 10-60 parts of Bulbus Fritillariae Ussuriensis, 15-60 parts of Radix et Rhizoma Rhei, 7-30 parts of Radix scutellariae, 7-30 parts of Lapis Chloriti, 10-50 parts of gypsum fibrosum, 5-20 parts of calculus bovis artifactus, and 15-60 parts of radix glycyrrhizae. The traditional Chinese medicine composition can inhibit 2019-nCoV replication in cells, so that cells infected by 2019-nCoV viruses have no lesion. Therefore, the traditional Chinese medicine composition can treat or prevent coronavirus related diseases.

Methods are disclosed for treating an acute respiratory distress syndrome, such as an acute respiratory distress syndrome associated with a viral infection, such as SARS-CoV2 (COVID-19) in a subject in need thereof. These methods include administering to the subject a pharmaceutical preparation comprising isolated matrix bound vesicles (MBV) derived from extracellular matrix.

Methods are disclosed for treating an acute respiratory distress syndrome, such as an acute respiratory distress syndrome associated with a viral infection, such as SARS-CoV2 (COVID-19) in a subject in need thereof. These methods include administering to the subject a pharmaceutical preparation comprising isolated matrix bound vesicles (MBV) derived from extracellular matrix.